scholarly journals Leukocyte chemotactic factor 2–related amyloidosis presenting with severe jaundice and hepatic encephalopathy

2021 ◽  
Vol 9 (12) ◽  
Author(s):  
Hussam Almasri ◽  
Almurtada Razok ◽  
Ahmed Badi ◽  
Muneera Almohannadi ◽  
Abdo Lutf ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Chemotactic Factor ◽  
Severe Jaundice

scholarly journals Leukocyte chemotactic factor 2 related amyloidosis presented with severe jaundice and hepatic encephalopathy.

2021 ◽  
Author(s):  
Hussam Almasri ◽  
Abdo Lutf ◽  
Almurtada Razok ◽  
Ahmed Badi ◽  
Muneera Almohannadi ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Chemotactic Factor ◽  
Al Amyloidosis ◽  
Severe Jaundice

One of the most recently identified types is Leukocyte chemotactic factor 2 amyloidosis (LECT 2) which was found to be common in certain ethnic backgrounds. It is suggested that the diagnosis of this type is vital to prevent any therapy-related complications when it is erroneously diagnosed as AL amyloidosis.

Hepatic Encephalopathy Can Impair Driving

2008 ◽  
Vol 38 (19) ◽  
pp. 28
Author(s):  
DAMIAN MCNAMARA
Keyword(s):  
Hepatic Encephalopathy

The Inhibitory Effect of Heparin and Related Glycosaminoglycans on Neutrophil Chemotaxis

1984 ◽  
Vol 52 (02) ◽  
pp. 134-137 ◽  
Author(s):  
Yaacov Matzner ◽  
Gerard Marx ◽  
Ruth Drexler ◽  
Amiram Eldor
Keyword(s):  
Specific Binding ◽  
Anticoagulant Activity ◽  
Neutrophil Migration ◽  
Inhibitory Effect ◽  
Chemotactic Factor ◽  
Human Neutrophils ◽  
Boyden Chamber ◽  
Neutrophil Chemotaxis ◽  
Inhibitory Effects ◽  
Chemotactic Factors

SummaryClinical observations have shown that heparin has antiinflammatory activities. The effect of heparin on neutrophil chemotaxis was evaluated in vitro in the Boyden Chamber. This method enabled differentiation between the direct effects of heparin on neutrophil migration and locomotion, and its effects on chemotactic factors. Heparin inhibited both the random migration and directed locomotion of human neutrophils toward zymosan-activated serum (ZAS) and F-met-leu-phe (FMLP). Inhibition was found to be dependent on the concentrations of the heparin and of the chemotactic factors. No specific binding of heparin to the neutrophils could be demonstrated, and heparin’s inhibitory effects were eliminated by simple washing of the cells. When added directly to the chamber containing chemotactic factor, heparin inhibited the chemotactic activity of ZAS but not that of FMLP, suggesting a direct inhibitory effect against C5a, the principal chemotactic factor in ZAS.Experiments performed with low-molecular-weight heparin, N-desulfated heparin, dextran sulfate, chondroitin sulfate and dextran indicated that the inhibitory effects of heparin on neutrophil chemotaxis are not related to its anticoagulant activity, but probably depend on the degree of sulfation of the heparin molecule.

Sign in / Sign up

Export Citation Format

Share Document