scholarly journals Paraparetic Guillain‐Barre syndrome: An uncommon diagnosis of acute flaccid paralysis of the lower limbs

2021 ◽  
Vol 9 (9) ◽  
Author(s):  
Prajjwol Luitel ◽  
Nischal Neupane ◽  
Niranjan Adhikari ◽  
Sujan Paudel ◽  
Bikram Prasad Gajurel ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Lower Limbs ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Zika virus infection causes temporary paralysis in adult mice with motor neuron synaptic retraction and evidence for proximal peripheral neuropathy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
John D. Morrey ◽  
Alexandre L. R. Oliveira ◽  
Hong Wang ◽  
Katherine Zukor ◽  
Mateus Vidigal de Castro ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Virus Infection ◽  
Motor Neurons ◽  
Zika Virus ◽  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
Zika Virus Infection ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

AbstractClinical evidence is mounting that Zika virus can contribute to Guillain-Barré syndrome which causes temporary paralysis, yet the mechanism is unknown. We investigated the mechanism of temporary acute flaccid paralysis caused by Zika virus infection in aged interferon αβ-receptor knockout mice used for their susceptibility to infection. Twenty-five to thirty-five percent of mice infected subcutaneously with Zika virus developed motor deficits including acute flaccid paralysis that peaked 8-10 days after viral challenge. These mice recovered within a week. Despite Zika virus infection in the spinal cord, motor neurons were not destroyed. We examined ultrastructures of motor neurons and synapses by transmission electron microscopy. The percent coverage of motor neurons by boutons was reduced by 20%; more specifically, flattened-vesicle boutons were reduced by 46%, and were normalized in recovering mice. Using electromyographic procedures employed in people to help diagnose Guillain-Barré syndrome, we determined that nerve conduction velocities between the sciatic notch and the gastrocnemius muscle were unchanged in paralyzed mice. However, F-wave latencies were increased in paralyzed mice, which suggests that neuropathy may exist between the sciatic notch to the nerve rootlets. Reversible synaptic retraction may be a previously unrecognized cofactor along with peripheral neuropathy for the development of Guillain-Barré syndrome during Zika virus outbreaks.

scholarly journals The Epidemiology of Guillain-Barré Syndrome in Children under 15 Years Old in Southwest Iran

2017 ◽  
Vol 2 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Ali Akbar Momen ◽  
Abdolhussein Shakurnia
Keyword(s):  
Incidence Rate ◽  
Acute Flaccid Paralysis ◽  
Annual Incidence ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
National Database ◽  
Accurate Estimation ◽  
Annual Incidence Rate ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Background: Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy, which has become the most common cause of acute flaccid paralysis. An accurate estimation of GBS occurrence would be useful for investigating the potential causal relationships between risk factors and GBS. The aim of the study was to analyze the incidence, annual time trend, and some epidemiological aspects of GBS in children in the Southwest of Iran. Methods: This was a retrospective study conducted by the Department of Pediatrics of Ahvaz Jundishapur University of Medical Sciences from January 2006 to December 2015. We extracted data from the national database of Acute Flaccid Paralysis Surveillance System. Results: A total of 184 subjects with GBS were assessed. The mean age of subjects was 5.43 ± 4.07 years. The average annual incidence rate of GBS was 1.51 per 100,000 children under 15 years old (95% CI: 1.29-1.73). There was no significant statistical difference in GBS incidence rate between girls and boys (p = 0.376). The highest and lowest proportions of the GBS occurrences were in autumn (32.2%) and summer (14.7%), respectively. Conclusions: The findings indicated that the annual incidence rate of GBS in this study was similar to those in other studies in this area.

P-PN020. Acute flaccid paralysis: Guillain-Barré Syndrome mimics

2021 ◽  
Vol 132 (8) ◽  
pp. e111-e112
Author(s):  
Si-Lei Fong ◽  
Mohamad Imran Idris ◽  
Stefanie Kar-Yan Hung ◽  
Benjamin Han-Sim Ng ◽  
Kheng-Chiew Chooi ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Epidemiology of Childhood Guillain-Barré Syndrome as a Cause of Acute Flaccid Paralysis in Honduras: 1989—1999

2003 ◽  
Vol 18 (11) ◽  
pp. 741-747 ◽  
Author(s):  
Marco R. Molinero ◽  
Daniel Varon ◽  
Kenton R. Holden ◽  
John T. Sladky ◽  
Ida B. Molina ◽  
...  
Keyword(s):  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Síndrome de Guillain-Barré: relato de caso

2020 ◽  
Vol 9 (5) ◽  
pp. 453-456
Author(s):  
Ana Gabriela Beraldo Castillo ◽  
Isabela Gonçalves Pirola ◽  
Janaine Mara Terezo Garcia ◽  
Gabriel Pina Paiva
Keyword(s):  
Differential Diagnosis ◽  
Rio De Janeiro ◽  
Acute Flaccid Paralysis ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
Porto Alegre ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

A síndrome de Guillain-Barré (SGB) é uma doença neurológica rara, de caráter autoimune, mais frequente no sexo masculino e com o aumento da idade, podendo ser precedida por processo infeccioso. Apresenta-se em 4 subtipos, os quais variam quanto ao curso e gravidade da doença, sendo o mais comum: a polineuropatia inflamatória desmielinizante aguda (PIDA), descrito neste relato de caso. A proposição do trabalho é mostrar a evolução precoce do quadro, que pode cursar com manifestações clínicas motoras, sensitivas e possivelmente autonômicas, podendo levar o paciente à insuficiência respiratória e posterior óbito. Discute-se também o diagnóstico e o tratamento preconizados. O primeiro envolve a obrigatoriedade de critérios essenciais, a presença de alguns critérios clínicos sugestivos, ausência de critérios que reduzem ou excluem a possibilidade da doença, além de exames laboratoriais (liquor) e eletroneuromiografia. Enquanto o tratamento é feito com Imunoglobulina humana intravenosa (IgIv) ou plasmaférese (Px), no intuito de evitar a progressão rápida e total dos sinais e sintomas, refletindo em um menor tempo de recuperação e minimização de déficits motores no paciente; além de cuidados de suporte multidisciplinares para prevenir possíveis complicações. Conclui-se, portanto, que o reconhecimento do quadro clínico, formas variantes, critérios diagnósticos e achados laboratoriais ou neurofisiológicos para diagnostico ou exclusão da doença se faz necessário para todos que atuam na emergência, visto que a doença é grave e de alta morbimortalidade. Descritores: Síndrome de Guillain-Barré; Imunoterapia; Plasmaférese.Referênciasvan den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA. Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014;10(8):469-82. Costa ACD. Síndrome de Guillain-Barré: uma revisão integrativa de literatura e de dados do Sistema Único de Saúde [monografia]. Brasília: Faculdade de Ciências da Saúde da Universidade de Brasília (Unb); 2016.Bolan RS, Dal Bó K, Vargas FR, Moretti GRF, Almeida LP, Almeida GKP et al. Síndrome de Guillain-Barré. Rev AMRIGS. 2007; 51(1):58-61.Shy ME. Neuropatias periféricas: Síndrome de Guillain-Barré. In: Goldman L, Schafer, AI. Cecil Medicina. v.2, 24 ed. Rio de Janeiro: Elsevier; 2014. cap. 428, p. 2784-85.Hauser SL, Amato AA. Síndrome de Guillain-Barré e outras neuropatias mediadas imunologicamente. In: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Medicina Interna de Harrison. v.2, 18ºed. Porto Alegre, Editora AMGH; 2013. cap. 385, p.3473- 79Marx A, Glass JD, Sutter RW. Differential diagnosis of acute flaccid paralysis and its role in poliomyelitis surveillance. Epidemiol Rev. 2000;22(2):298-316. Brasil. Ministério da Saúde. Síndrome de Guillain-Barré: Protocolo Clínico e Diretrizes Terapêuticas. Portaria SAS/MS n 497, 2009, 14 p. [Acesso em: 28 mar. 2019] Disponível em: <http://neurologiahu.ufsc.br/files/2012/08/Protocolo-MS_Guillain-Barr%C3%A9-2009.pdf>.Oliveira E, Monteiro N, Sequeira M, Saraiva JP. Síndrome de Guillain-Barré: experiência de uma Unidade de Cuidados Intensivos e revisão da literatura. Medicina Interna. 2012; 19(3):130-39.Araujo AM, Dias LC, Silva CMS, Gaspar LC, Anjos JLM. Treinamento Muscular Inspiratório na Síndrome de Guillain-Barré: Relato de Caso. RPF. 2016;6(4):448-54.

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