scholarly journals Clinical variability of recurrent oral HSV‐1 infection with a high level of serum IgG antibody: Three case reports

2021 ◽  
Vol 9 (9) ◽  
Author(s):  
Dewi Zakiawati ◽  
Muhammad Al Farisyi ◽  
Indah Suasani Wahyuni
Keyword(s):  
Case Reports ◽  
Igg Antibody ◽  
Clinical Variability ◽  
Serum Igg ◽  
High Level ◽  
Hsv 1

Serum Immunoglobulin G level and Neutrophils to Lymphocytes Ratio Associated with the Prognosis of Neuromyelitis Optica Spectrum Disorder

2021 ◽  
Vol 18 ◽  
Author(s):  
Ying Tong ◽  
Li Wang ◽  
Kai Liu ◽  
Weishi Liu ◽  
Shen Li ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuromyelitis Optica ◽  
Immunoglobulin G ◽  
Peripheral Blood ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Positive Group ◽  
Serum Igg ◽  
High Level ◽  
Igg Level

Objective: To investigate the factors related to the prognosis of neuromyelitis optica spectrum disorder (NMOSD) in cerebrospinal fluid and peripheral blood examination. Methods: In this study, we collected 111 patients who were admitted to the First Affiliated Hospital of Zhengzhou University between January 2016 and January 2018 and diagnosed with NMOSD. The patients were divided into the relapse group (n=48) and remission group (n=67). Before treatment, all the patients underwent a routine cerebrospinal fluid (CSF) and peripheral blood test on the second morning of admission. The association between laboratory data and disease prognosis was evaluated. Results: The immunoglobulin G (IgG) level in the serum showed a strong correlation with the relapse of patients, especially in the aquaporin-4-Antibody (AQP4-Ab) positive group (p<0.01). A high level of serum IgG concentration was associated with the relapse of NMOSD, especially in the anti-AQP4 positive group. The area under the receiver operating characteristic (ROC) curve of serum IgG level was 0.888 (p0.001, 95%CI: 0.808-0.968). The ratio of neutrophils to lymphocytes (NLR) was associated with the disability degree of NMOSD patients in 3 years. The NLR value was a linear correlation with final Expanded Disability Status Scale (EDSS) scores. Patients with a high level of NLR value presented an increased degree of disability in the following three years (R2=0.053, p=0.015). Conclusion: The serum IgG level and NLR of first-attack patients were correlated with the prognosis of NMOSD.

scholarly journals Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Victor J. Johnson ◽  
Jeffrey S. Reynolds ◽  
Wei Wang ◽  
Kara Fluharty ◽  
Berran Yucesoy
Keyword(s):  
Lymph Nodes ◽  
B Lymphocytes ◽  
Case Reports ◽  
Inhalation Exposure ◽  
Cytokine Gene Expression ◽  
Respiratory Problems ◽  
Specific Igg ◽  
High Level ◽  
Lymphocyte Populations ◽  
Draining Lymph Nodes

Ortho-Phthalaldehyde (OPA) has been approved for high-level sterilization of heat-sensitive medical instruments and is increasingly being used as a replacement in the healthcare industry for glutaraldehyde, a known sensitizer. Numerous case reports have been published indicating workers and patients experiencing respiratory problems, anaphylaxis, skin reactivity, and systemic antibody production. Our laboratory previously demonstrated that OPA is a dermal sensitizer in mice. The goal of the present study was to determine if OPA is a respiratory sensitizer following inhalation exposure. Mice were exposed to OPA vapor and airway and lymph nodes were examined for cytokine gene expression and alterations in lymphocyte populations. Inhalation of OPA for 3 days resulted in a concentration-dependent increase in lymphocyte proliferation, mainly B lymphocytes, in the draining lymph nodes. A secondary challenge of mice with OPA resulted in a dramatic increase in the population of B lymphocytes expressing IgE. Expression of Th2 (IL-4, IL-5, and IL-13) and anti/proinflammatory (IL-10, TNFα, and IL-1β) cytokine genes was upregulated in the lymph nodes and the nasal mucosa. Mice exposed to the higher concentrations of OPA-produced OPA-specific IgG1 antibodies indicating systemic sensitization. These findings provide evidence that OPA has the potential to cause respiratory sensitization in mice.

scholarly journals Clinical Variability of Hypophosphatasia in Colombian Patients: Case Reports

2021 ◽  
Vol 11 (2) ◽  
pp. 56-64
Author(s):  
Ana Maria Zarante Bahamon ◽  
Juan Carlos Prieto Rivera ◽  
Jorge Rojas ◽  
Vladimir Gonzalez Lopez ◽  
Victor Vargas ◽  
...  
Keyword(s):  
Case Reports ◽  
Clinical Variability

scholarly journals Pattern of resilient age-related measles immunity

2020 ◽  
Vol 10 (2) ◽  
pp. 375-380
Author(s):  
A. G. Sonis ◽  
O. A. Gusyakova ◽  
F. N. Gilmiyarova ◽  
A. A. Ereshchenko ◽  
N. K. Ignatova ◽  
...  
Keyword(s):  
Measles Virus ◽  
Age Groups ◽  
Igg Antibody ◽  
Infection Level ◽  
Age Related ◽  
Specific Igg ◽  
Young Subjects ◽  
High Level ◽  
Medical University ◽  
Igg Level

Epidemiological situation describing global measles spread is ambiguous. Along with countries succeeded in measles eradication, there are those wherein measles rate remains at quite high level. Because measles is a vaccine-preventable infection, it may then be eradicated solely by ensuring sufficient population coverage with preventive vaccination. The aim of our study was to assess level of measles immunity in medical workers at the Clinics of Samara State Medical University as well as the Samara State Medical University. There were enrolled 1503 subjects (aged 18–79 years), among which all individuals under 55 (77.58%) but not older counterparts provided with medical record on previous measles vaccination or measles infection. Level of serum measles virus-specific IgG antibodies was measured by using ELISA (VektoKor-IgG, JSC Vector-Best, Novosibirsk), with mean concentration ranging in general population within 1.02±0.02 IU/ ml. Positive results were observed in 72.52% of the examined individuals. Average vs. high measles virus-specific IgG level was detected in 52.90% (mean age — 41.4±0.5 years) and 19.62% (mean age — 54.2±0.72 years) of individuals, whereas at level below threshold — in 27.48% of subjects (mean age — 33.25±0.53 years). Thus, in 34.16% of the surveyed vaccinated individuals mostly presented by young subjects contained anti-measles virus-specific antibodies below protective level. Older age groups were shown to increase in average IgG amount with age. Interestingly, age-related measles immunity pattern was observed: percentage of subjects with high vs. low measles virus-specific IgG level increases and decreases, respectively. Taking into consideration a large percentage of subjects previously vaccinated against measles among carriers of low measles immunity, it may be concluded that measles virus-specific IgG antibody level must be monitored in young adulthood to decide of whether subsequent revaccination is necessary.

scholarly journals Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants

2021 ◽  
Author(s):  
Jinbiao Liu ◽  
Brittany H Bodnar ◽  
Xu Wang ◽  
Peng Wang ◽  
Fengzhen Meng ◽  
...  
Keyword(s):  
Protective Efficacy ◽  
Serum Antibody ◽  
Specific Serum ◽  
Effective Immune Response ◽  
Serum Igg ◽  
High Level ◽  
Protection Against Infection ◽  
Antibody Levels ◽  
Serum Igg Levels ◽  
Igg Level

Both Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.

scholarly journals Urologic guidelines for the care and management of people with spina bifida

2020 ◽  
Vol 13 (4) ◽  
pp. 479-489
Author(s):  
David B. Joseph ◽  
Michelle A. Baum ◽  
Stacy T. Tanaka ◽  
Dominic C. Frimberger ◽  
Rosalia Misseri ◽  
...  
Keyword(s):  
Renal Function ◽  
Spina Bifida ◽  
Best Practice ◽  
Case Reports ◽  
English Literature ◽  
Age Groups ◽  
Standard Of Care ◽  
Urinary Continence ◽  
Clinical Questions ◽  
High Level

PURPOSE: The life expectancy for people with spina bifida has increased, thus resulting in greater need for guidelines in urologic care in order to protect normal renal function, to develop strategies for urinary continence, and to advance independence through adult years. METHODS: The English literature was assessed from 2002–2015; greater than 300 publications identified. Case reports and opinion pieces were eliminated leaving 100 for in depth review. Clinical questions were then established for each age group that allowed for focused assessment. RESULTS: There was no Level 1 evidence for any of the defined clinical questions. This resulted in group consensus for all questions throughout all age groups. Guidelines were provided for identifying a symptomatic urinary infection, the role of urodynamic bladder testing and identification of bladder hostility, determining methods of renal function assessment and surveillance, the initiation of continence control, and transitioning to self-care through the teen and adult years. CONCLUSION: Urologic guidelines continue to be based on clinical consensus due to the lack of high level evidence-based research. Further research is required in all aspects of urologic management. While not the “Standard of Care,” these guidelines should be considered “Best Practice”.

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