scholarly journals Management of massive splenomegaly

2021 ◽  
Vol 9 (8) ◽  
Author(s):  
Victoria E. Hudson ◽  
Priya S. Rogers ◽  
John M. H. Bennett
Keyword(s):  
Massive Splenomegaly

scholarly journals Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 166-173 ◽  
Author(s):  
JJ Shuster ◽  
JM Falletta ◽  
DJ Pullen ◽  
WM Crist ◽  
GB Humphrey ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Recursive Partitioning ◽  
Blast Cell ◽  
Recursive Partitioning Analysis ◽  
Important Predictor ◽  
Massive Splenomegaly ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Cell Expression

Two hundred fifty-three children with newly diagnosed T-cell acute lymphoblastic leukemia (ALL), who were treated uniformly with modified LSA2L2 therapy, were evaluated using univariate and recursive partition analyses to define clinical or biologic features associated with risk of treatment failure. Overall event-free survival (EFS) at 4 years was 43% (SE = 4%). Factors examined included white blood cell (WBC) level, age, gender, race (black v other), presence of a mediastinal mass, hepatomegaly, splenomegaly, marked lymphadenopathy, hemoglobin level, platelet count, blast cell expression of antigens such as the common acute lymphoblastic leukemia antigen (CALLA, CD10), HLA-DR, and T-cell- associated antigens (CD3, CD4, CD8, CD7, CD5, and THY). Univariate analysis showed that age less than or equal to 5 or less than or equal to 7 years, WBC level less than 10, less than 25, less than 50 or less than 100 x 10(3)/microL, and blast cell expression of CD4, CD8, or CALLA were associated with significantly better EFS, while hepatomegaly and splenomegaly were associated with worse EFS. Recursive partitioning analysis showed that the most important single favorable prognostic factor was a WBC level less than 50 x 10(3)/microL and, for patients with WBC counts below this level, the most important predictor of EFS was blast cell expression of the pan-T antigen defined by the monoclonal antibody (MoAb), L17F12 (CD5). For patients with higher WBC levels, the most important predictor of EFS was blast cell expression of THY antigen. The recursive partitioning analysis defined three groups of patients with widely varied prognoses identified as follows: (1) those with a WBC count less than 50 x 10(3)/microL who lacked massive splenomegaly and had blasts expressing CD5 had the best prognosis (66%, SE = 7%, EFS 4 years, n = 84); (2) those with (b1) WBC counts less than 50 x 10(3)/microL with either massive splenomegaly or who had blasts lacking CD5 expression, or (b2) WBC counts greater than 50 x 10(3)/microL with expression of the THY antigen had an intermediate prognosis (39%, SE = 7% EFS at 4 years, n = 94); (3) those with WBC counts greater than 50 x 10(3)/microL and whose blasts lacked expression of THY antigen had the poorest outcome (EFS = 19% at 4 years, SE = 8%, n = 63). A three-way comparison of EFS according to these groupings showed significant differences among the three patient groups (P less than .001). The recursive partitioning was able to classify 241 (95%) of the patients.(ABSTRACT TRUNCATED AT 400 WORDS)

Three Rwandan Children With Massive Splenomegaly and Epstein-Barr Virus–associated Lymphoproliferative Disorders

2016 ◽  
Vol 38 (5) ◽  
pp. e158-e161 ◽  
Author(s):  
DeAnna Friedman-Klabanoff ◽  
Allison Ball ◽  
Samuel Rutare ◽  
Natalie McCall ◽  
Douglas P. Blackall
Keyword(s):  
Epstein Barr Virus ◽  
Lymphoproliferative Disorders ◽  
Massive Splenomegaly ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Massive splenomegaly due to B-cell lymphoma: A case report

2018 ◽  
Vol 48 ◽  
pp. 76-78 ◽  
Author(s):  
M. Djokic ◽  
B. Plesnik ◽  
M. Petric ◽  
B. Trotovsek
Keyword(s):  
Case Report ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Massive Splenomegaly

scholarly journals Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

Blood ◽  
1990 ◽  
Vol 75 (1) ◽  
pp. 166-173 ◽  
Author(s):  
JJ Shuster ◽  
JM Falletta ◽  
DJ Pullen ◽  
WM Crist ◽  
GB Humphrey ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Lymphoblastic Leukemia ◽  
Recursive Partitioning ◽  
Blast Cell ◽  
Recursive Partitioning Analysis ◽  
Important Predictor ◽  
Massive Splenomegaly ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Cell Expression

Abstract Two hundred fifty-three children with newly diagnosed T-cell acute lymphoblastic leukemia (ALL), who were treated uniformly with modified LSA2L2 therapy, were evaluated using univariate and recursive partition analyses to define clinical or biologic features associated with risk of treatment failure. Overall event-free survival (EFS) at 4 years was 43% (SE = 4%). Factors examined included white blood cell (WBC) level, age, gender, race (black v other), presence of a mediastinal mass, hepatomegaly, splenomegaly, marked lymphadenopathy, hemoglobin level, platelet count, blast cell expression of antigens such as the common acute lymphoblastic leukemia antigen (CALLA, CD10), HLA-DR, and T-cell- associated antigens (CD3, CD4, CD8, CD7, CD5, and THY). Univariate analysis showed that age less than or equal to 5 or less than or equal to 7 years, WBC level less than 10, less than 25, less than 50 or less than 100 x 10(3)/microL, and blast cell expression of CD4, CD8, or CALLA were associated with significantly better EFS, while hepatomegaly and splenomegaly were associated with worse EFS. Recursive partitioning analysis showed that the most important single favorable prognostic factor was a WBC level less than 50 x 10(3)/microL and, for patients with WBC counts below this level, the most important predictor of EFS was blast cell expression of the pan-T antigen defined by the monoclonal antibody (MoAb), L17F12 (CD5). For patients with higher WBC levels, the most important predictor of EFS was blast cell expression of THY antigen. The recursive partitioning analysis defined three groups of patients with widely varied prognoses identified as follows: (1) those with a WBC count less than 50 x 10(3)/microL who lacked massive splenomegaly and had blasts expressing CD5 had the best prognosis (66%, SE = 7%, EFS 4 years, n = 84); (2) those with (b1) WBC counts less than 50 x 10(3)/microL with either massive splenomegaly or who had blasts lacking CD5 expression, or (b2) WBC counts greater than 50 x 10(3)/microL with expression of the THY antigen had an intermediate prognosis (39%, SE = 7% EFS at 4 years, n = 94); (3) those with WBC counts greater than 50 x 10(3)/microL and whose blasts lacked expression of THY antigen had the poorest outcome (EFS = 19% at 4 years, SE = 8%, n = 63). A three-way comparison of EFS according to these groupings showed significant differences among the three patient groups (P less than .001). The recursive partitioning was able to classify 241 (95%) of the patients.(ABSTRACT TRUNCATED AT 400 WORDS)

Chronic falciparum malaria causing massive splenomegaly 9 years after leaving an endemic area

2005 ◽  
Vol 182 (4) ◽  
pp. 186-188 ◽  
Author(s):  
Benjamin P Howden ◽  
Gautam Vaddadi ◽  
M Lindsay Grayson ◽  
Joseph Manitta
Keyword(s):  
Falciparum Malaria ◽  
Endemic Area ◽  
Massive Splenomegaly

scholarly journals Visceral leishmaniasis with haemophagocytic lymphohistiocytosis

2019 ◽  
Vol 12 (2) ◽  
pp. e226361
Author(s):  
John Titus George ◽  
Mohammad Sadiq ◽  
Elanthenral Sigamani ◽  
Alice Joan Mathuram
Keyword(s):  
Visceral Leishmaniasis ◽  
Liposomal Amphotericin ◽  
Leishmania Donovani ◽  
Final Diagnosis ◽  
Reticuloendothelial System ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Intermittent Fever ◽  
Massive Splenomegaly ◽  
Loss Of Weight ◽  
Distributive Shock

A 27-year-old man presented with high-grade intermittent fever for 4 months, generalised fatigue for 2 months, intermittent gum bleeds for 1 month and loss of weight of 15 kg. He appeared cachectic with generalised wasting, had pallor and features of reticuloendothelial system proliferation. His liver span was 17 cm. He had massive splenomegaly. His cardiovascular, respiratory and neurological examination were normal. He was diagnosed to have visceral leishmaniasis (VL) based on bone marrow (BM) examination that showed Leishmania donovani (LD) bodies and was treated with liposomal amphotericin (LA). During the course of therapy, he developed bleeding from various mucosal and venepuncture sites. His further evaluation, which included a repeat BM aspirate, showed haemophagocytes. Final diagnosis made was VL with secondary haemophagocytic lymphohistiocytosis. He was continued on LA with intravenous hydrocortisone. He developed refractory distributive shock with multiorgan dysfunction and succumbed to his illness.

The Feasibility and Safety of Laparoscopic Splenectomy for Massive Splenomegaly: A Comparative Study

2011 ◽  
Vol 171 (1) ◽  
pp. e55-e60 ◽  
Author(s):  
Jin Zhou ◽  
Zhong Wu ◽  
Yunqiang Cai ◽  
Yichao Wang ◽  
Bing Peng
Keyword(s):  
Comparative Study ◽  
Laparoscopic Splenectomy ◽  
Massive Splenomegaly

Massive Splenomegaly, An Unexpected Diagnosis

Pathology ◽  
2019 ◽  
Vol 51 ◽  
pp. S41
Author(s):  
Richard Blennerhassett ◽  
Georgia McCaughan ◽  
Elizabeth Tegg
Keyword(s):  
Massive Splenomegaly
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