scholarly journals Primary cardiac angiosarcoma directly invading the right lung: An autopsy report

2021 ◽  
Vol 9 (8) ◽  
Author(s):  
Takumi Kiwaki ◽  
Akira Ishihara ◽  
Takanori Toyama ◽  
Hiroaki Kusaka ◽  
Hiroaki Kataoka
Keyword(s):  
Cardiac Angiosarcoma ◽  
Autopsy Report ◽  
The Right

scholarly journals Primary cardiac angiosarcoma directly invading the right lung: An autopsy report

2020 ◽  
Author(s):  
Takumi Kiwaki ◽  
Akira Ishihara ◽  
Takanori Toyama ◽  
Hiroaki Kusaka ◽  
Hiroaki Kataoka
Keyword(s):  
Cardiac Angiosarcoma ◽  
Autopsy Report ◽  
The Right

scholarly journals Resection of primary cardiac angiosarcoma infiltrating the right atrioventricular junction and tricuspid valve: a case report

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Lubna Bakr ◽  
Hussam AlKhalaf ◽  
Ahmad Takriti
Keyword(s):  
Surgical Resection ◽  
Tricuspid Valve ◽  
Right Atrium ◽  
Large Mass ◽  
Small Mass ◽  
Malignant Tumours ◽  
Atrioventricular Junction ◽  
Cardiac Angiosarcoma ◽  
Complete Surgical Resection ◽  
The Right

Abstract Background Primary cardiac tumours are extremely rare. Most of them are benign. Sarcomas account for 95% of the malignant tumours. Prognosis of primary cardiac angiosarcoma remains poor. Complete surgical resection is oftentimes hampered when there is extensive tumour involvement into important cardiac apparatus. We report a case of cardiac angiosarcoma of the right atrium and ventricle, infiltrating the right atrioventricular junction and tricuspid valve. Case presentation Initially, a 22-year-old man presented with dyspnoea. One year later, he had recurrent pericardial effusion. Afterwards, echocardiography revealed a large mass in the right atrium, expanding from the roof of the right atrium to the tricuspid valve. The mass was causing compression on the tricuspid valve, and another mass was seen in the right ventricle. Complete resection of the tumour was impossible. The mass was resected with the biggest possible margins. The right atrium was reconstructed using heterologous pericardium. The patient’s postoperative course was uneventful. Postoperative echocardiography showed a small mass remaining in the right side of the heart. Histopathology and immunohistochemistry confirmed the diagnosis of angiosarcoma. The patient underwent adjuvant chemotherapy and radiotherapy later on. He survived for 1 year and 5 days after the surgery. After a diagnosis of lung and brain metastases, he ended up on mechanical ventilation for 48 h and died. Conclusions Surgical resection combined with postoperative chemotherapy and radiotherapy is feasible even in patients with an advanced stage of cardiac angiosarcoma when it is impossible to perform complete surgical resection.

scholarly journals Cardiac Angiosarcoma on the Right Atrium: Two Cases

2012 ◽  
Vol 45 (2) ◽  
pp. 120-123 ◽  
Author(s):  
Won Kyoun Park ◽  
Sung-Ho Jung ◽  
Ju Yong Lim
Keyword(s):  
Right Atrium ◽  
Cardiac Angiosarcoma ◽  
The Right

scholarly journals Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report

2016 ◽  
Vol 9 (2) ◽  
pp. 363-367 ◽  
Author(s):  
Sophie Schur ◽  
Rainer Hamacher ◽  
Thomas Brodowicz
Keyword(s):  
Receptor Tyrosine Kinase ◽  
Multidisciplinary Approach ◽  
Kinase Inhibitor ◽  
Response To Treatment ◽  
Conventional Chemotherapy ◽  
Cardiac Angiosarcoma ◽  
Dismal Prognosis ◽  
Heart Tumors ◽  
The Right ◽  
Severe Hypersensitivity Reaction

Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac angiosarcoma who showed a severe hypersensitivity reaction to conventional chemotherapy with taxanes but an excellent response to treatment with the multitargeted receptor tyrosine kinase inhibitor pazopanib.

Cardiac Angiosarcoma of the Right Atrium with Cardiac Tamponade

2016 ◽  
Vol 12 (5) ◽  
pp. 1-5
Author(s):  
Hirotaka Sato ◽  
Kei Aizawa ◽  
Arata Muraoka ◽  
Hirohiko Akutsu ◽  
Yoshio Misawa
Keyword(s):  
Cardiac Tamponade ◽  
Right Atrium ◽  
Cardiac Angiosarcoma ◽  
The Right

scholarly journals Rapidly progressive respiratory failure with multiple halo signs on computed tomography in a patient with primary cardiac angiosarcoma derived from the right atrium: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Masaoki Saito ◽  
Takeshi Saraya ◽  
Miku Oda ◽  
Toshinori Minamishima ◽  
Ken Kongoji ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cardiac Output ◽  
Respiratory Failure ◽  
Lung Tissue ◽  
Right Atrium ◽  
Cardiac Ct ◽  
Loss Of Consciousness ◽  
Cardiac Angiosarcoma ◽  
Thoracic Ct ◽  
The Right

Abstract Background Primary cardiac neoplasms are extremely rare, with an autopsy incidence of 0.0001–0.003%. Primary cardiac sarcoma is usually derived from the right atrium and it manifests as chest pain, arrhythmia, hemoptysis, dyspnea, and fatigue. The most common target organ for metastasis of primary angiosarcoma is the lungs, but the radiological-pathological correlation has been rarely reported. Case presentation A 38-year-old healthy Japanese man was admitted to our hospital with persistent hemoptysis, exaggerated dyspnea, and two episodes of loss of consciousness in the past 3 months. Non-enhanced thoracic computed tomography (CT) revealed multiple scattered nodules with halo signs. Contrast-enhanced thoracic CT revealed a filling defect in the right atrium, which corresponded to the inhomogeneously enhancing tumor in the right atrium on enhanced electrocardiogram-gated cardiac CT. On day 2, acute respiratory failure occurred, and the patient was placed on mechanical ventilation. The patient was diagnosed with primary cardiac angiosarcoma based on the urgent transcatheter biopsied specimen of the right atrium mass and was treated with intravenous administration of doxorubicin. However, his respiratory status rapidly deteriorated, and he died on day 20. Postmortem biopsy showed that the multiple lung nodules with the halo signs corresponded to the intratumoral hemorrhagic necrosis and peripheral parenchymal hemorrhage in their background, suggesting the fragility of the lung tissue where the tumor had invaded, which caused hemoptysis. Furthermore, two episodes of loss of consciousness occurred probably due to a decreased cardiac output because of a massive tumor occupying the right atrium, recognized as an inhomogeneous centripetal enhancement on enhanced electrocardiogram-gated cardiac CT. Conclusions This case clearly demonstrated that primary cardiac angiosarcoma could expand in the right atrial cavity, which led to a decreased cardiac output resulting in repeated syncope, together with the fragility of lung tissue by tumor invasion, thereby generating a halo sign on thoracic CT.

CT Findings of Pulmonary Metastases from Primary Cardiac Angiosarcoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Yan Chen ◽  
Xiang He ◽  
Jianfeng Shang ◽  
Nan Zhang ◽  
Xiaodan Li ◽  
...  
Keyword(s):  
Pulmonary Metastasis ◽  
Pulmonary Metastases ◽  
Mediastinal Lymph Node ◽  
Pulmonary Nodules ◽  
Maximum Diameter ◽  
Imaging Features ◽  
Cardiac Angiosarcoma ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
The Right

Background: Primary cardiac angiosarcoma is a rare malignancy with high predilection to involve surrounding structures such as pulmonary metastases. We analysed the chest computed tomography (CT) imaging features of patients diagnosed with primary cardiac angiosarcoma with pulmonary metastases in this study. Methods: This study retrospectively reviewed 12 patients with confirmed primary cardiac angiosarcoma, out of which eight (all men) with pulmonary metastasis were included in the analysis. The patients’ age ranged from 17 to 74 (mean: 48) years. CT was performed in all patients with unenhanced, contrast-enhanced, and both scans were done in 1, 3 and 4 patients, respectively. Results: Nodular lesions were observed in 7 patients with multiple solid nodules observed in 6 out of 7 patients. A solitary solid nodule was found in the remaining patient in the upper lobe and apical segment of the right lung with a diameter of 11.7 mm. All solid nodules were distributed along with bronchovascular bundles in the lungs, and their maximum diameter ranged from 2.3 to 19.9 mm. Nodules larger than 10 mm in diameter were heterogeneously enhanced on contrast-enhanced CT images (5/8 patients), whereas those smaller than 10 mm were homogeneously enhanced (3/8 patients). Other imaging features, namely the tree-in-bud pattern, emphysema, pleural effusion, and mediastinal lymph node enlargement, were observed in 4, 3, 3, and 2 patients, respectively. Conclusion: CT enhancement features of pulmonary metastasis in patients with primary cardiac angiosarcoma depend on the size of pulmonary nodules, with larger ones being heterogeneous and smaller ones homogeneous. Other signs are less noticed.

scholarly journals Surgical Treatment of a Giant Primary Cardiac Angiosarcoma

2008 ◽  
Vol 51 (4) ◽  
pp. 237-239 ◽  
Author(s):  
Maruf Sanli ◽  
Bulent Tuncozgur ◽  
Alper Sevinc ◽  
Bahadir Daglar ◽  
Kemal Bakir ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Surgical Resection ◽  
Right Atrium ◽  
Combined Treatment ◽  
Histopathological Diagnosis ◽  
Cardiac Angiosarcoma ◽  
Resected Tumor ◽  
Well Differentiated ◽  
The Right ◽  
Large Primary

Primary cardiac angiosarcoma is a rare tumor, and surgical resection is often required to relieve its symptoms. A 54-year-old male with a large primary cardiac angiosarcoma is described in this case report. The tumor was located in the right atrium and right ventricle. The bulk was resected with the right coronary artery (RCA), and partial right atrium and partial right ventricle resections were performed during cardiopulmonary bypass. The resected tumor measured 15 x 10 x 8 cm, and the histopathological diagnosis was well differentiated primary cardiac angiosarcoma. In the postoperative period, the patient was followed up for 22 months, and radiotherapy and chemotherapy were performed for metastases. The optimal therapy for cardiac angiosarcoma is still controversial, but combined treatment including surgical resection should be considered.

Primary cardiac angiosarcoma masquerading as intracardiac thrombus

2020 ◽  
Vol 13 (12) ◽  
pp. e236806
Author(s):  
Nicholas Villano ◽  
William P Flavin ◽  
Pamela Tsing
Keyword(s):  
Atrial Tachycardia ◽  
Target Lesion ◽  
Right Atrial ◽  
Gastric Body ◽  
Intracardiac Thrombus ◽  
Significant Morbidity ◽  
Cardiac Angiosarcoma ◽  
Right Atrial Mass ◽  
History Of ◽  
The Right

A 49-year-old man with a recent history of atrial tachycardia and intracardiac thrombus presented to the emergency department with melena and cardiac tamponade. Physical examination was notable for a vascular mass at the right lower gingival sulcus and a right chest wall nodule. Enteroscopy revealed a target lesion with friable ulcer in the gastric body. Cardiac MRI revealed a large right atrial mass, previously thought to represent thrombus. The patient was ultimately diagnosed with primary cardiac angiosarcoma (PCAS) by histopathology of gingival, gastric and subcutaneous lesions. This case illustrates the significant morbidity and mortality resulting from aggressive local invasion and growth of PCAS, as well as the challenge of differentiating between primary thrombosis and vascular malignancy. Misdiagnosis of this elusive clinical entity may be costly, potentially resulting in delay of intervention and adverse effects of alternate therapies such as anticoagulation.

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