scholarly journals Adverse reaction of methylprednisolone pulse therapy: Acute respiratory distress syndrome

2021 ◽  
Vol 9 (7) ◽  
Author(s):  
Fereshteh Ashtari ◽  
Rasool Soltani ◽  
Shervin Shokouhi ◽  
Ali Rismanbaf ◽  
Somayeh Hajiahmadi ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Pulse Therapy ◽  
Methylprednisolone Pulse Therapy ◽  
Methylprednisolone Pulse

Acute Respiratory Distress Syndrome after Aprotinin Infusion

1997 ◽  
Vol 31 (4) ◽  
pp. 429-432 ◽  
Author(s):  
Zeljko Vucicevic ◽  
Tomislav Suskovic
Keyword(s):  
Adverse Reaction ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Anaphylactoid Reaction ◽  
Adverse Reactions ◽  
Distress Syndrome ◽  
Ventilatory Support ◽  
Allergic Reactions ◽  
Case Summary

Objective To report a case of acute respiratory distress syndrome (ARDS) following first exposure to aprotinin. Case Summary A 24-year-old previously healthy white man was treated with aprotinin infusion because of bleeding following tonsillectomy. The patient had never been treated with aprotinin before, including local application of different hemostatics containing the aprotinin component. Two hours later, hypotension and severe ARDS developed. A full recovery was noted after discontinuation of the drug and prolonged ventilatory support. Discussion To our knowledge, this is the first reported case of ARDS following first administration of aprotinin, although serious adverse effects at first exposure have been reported. We propose two possible mechanisms for this adverse reaction: a nonallergic or anaphylactoid reaction with direct degranulation of mast cells and basophils by aprotinin, and microthrombosis of the small pulmonary arterioles precipitated by aprotinin. Conclusions Most clinicians consider aprotinin to be a safe drug, especially if it has not been administered before. Reexposure carries a high risk of allergic reactions because of possible sensitization. Nonimmunologic, toxic, or idiosyncratic adverse reactions can be expected at first exposure to any drug, as well as to aprotinin.

scholarly journals Improved Oxygenation by Steroid Pulse Therapy in Early-Phase Acute Respiratory Distress Syndrome

2007 ◽  
Vol 18 (1) ◽  
pp. 1-9
Author(s):  
Yuka Sumi ◽  
Hiroshi Ogura ◽  
Kouji Akashi ◽  
Yoshiki Tohma ◽  
Hisayuki Tabuse ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Early Phase ◽  
Distress Syndrome ◽  
Pulse Therapy ◽  
Steroid Pulse Therapy ◽  
Steroid Pulse

COVID-19 – eine vaskuläre Systemerkrankung

2020 ◽  
Vol 49 (10) ◽  
pp. 418-421
Author(s):  
Christopher Werlein ◽  
Peter Braubach ◽  
Vincent Schmidt ◽  
Nicolas J. Dickgreber ◽  
Bruno Märkl ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome

ZUSAMMENFASSUNGDie aktuelle COVID-19-Pandemie verzeichnet mittlerweile über 18 Millionen Erkrankte und 680 000 Todesfälle weltweit. Für die hohe Variabilität sowohl der Schweregrade des klinischen Verlaufs als auch der Organmanifestationen fanden sich zunächst keine pathophysiologisch zufriedenstellenden Erklärungen. Bei schweren Krankheitsverläufen steht in der Regel eine pulmonale Symptomatik im Vordergrund, meist unter dem Bild eines „acute respiratory distress syndrome“ (ARDS). Darüber hinaus zeigen sich jedoch in unterschiedlicher Häufigkeit Organmanifestationen in Haut, Herz, Nieren, Gehirn und anderen viszeralen Organen, die v. a. durch eine Perfusionsstörung durch direkte oder indirekte Gefäßwandschädigung zu erklären sind. Daher wird COVID-19 als vaskuläre Multisystemerkrankung aufgefasst. Vor dem Hintergrund der multiplen Organmanifestationen sind klinisch-pathologische Obduktionen eine wichtige Grundlage der Entschlüsselung der Pathomechanismen von COVID-19 und auch ein Instrument zur Generierung und Hinterfragung innovativer Therapieansätze.

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