scholarly journals Wegener's granulomatosis and differential diagnosis of mucosal leishmaniasis

2021 ◽  
Vol 9 (6) ◽  
Author(s):  
Jesús Rojas‐Jaimes ◽  
Víctor Hugo Rojas‐Figueroa ◽  
Rodrigo Corcuera ◽  
José Arenas ◽  
Julio García‐Reynoso
Keyword(s):  
Differential Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Mucosal Leishmaniasis

Sinonasal T-cell Lymphoma and Wegener's Granulomatosis: Aspects in Early Differential Diagnosis

1996 ◽  
Vol 10 (4) ◽  
pp. 239-246
Author(s):  
Anders Cervin ◽  
Michael Dictor ◽  
Olof Kalm
Keyword(s):  
Differential Diagnosis ◽  
In Situ Hybridization ◽  
T Cell ◽  
Wegener’S Granulomatosis ◽  
Cell Lymphoma ◽  
Wegener's Granulomatosis ◽  
T Cell Lymphoma ◽  
Upper Airways ◽  
Gastrointestinal Complications

The clinical course of 12 patients with sinonasal T-cell lymphoma retrospectively diagnosed using in situ hybridization for Epstein-Barr virus RNA was compared with that of 10 recently treated patients with Wegener's granulomatosis (WG) in the upper airways. In particular, we studied the presenting signs and symptoms of both diseases, which commonly offer a problem in differential diagnosis at the clinical and pathological level. A bimodal age distribution was suggested in both T-cell lymphoma and WG; five patients with T-cell lymphoma developed disease prior to 40 years of age. Four of the 12 lymphoma patients had a history of “chronic rhinitis” for several years before developing mucosal ulcerations, which were initially unilateral, as opposed to the bilateral ulcerations in early sinonasal WG. Two lymphoma patients had swelling of the nasal dorsum and cheek. In contrast to the WG patients, cases of T-cell lymphoma did not exhibit associated clinical signs of arthritis, conjunctivitis, pulmonary lesions, or nephritis in the early stage of the disease. Nine of the patients with T-cell lymphoma presenting as a sinonasal lesion developed disseminated disease, variably including infiltrates in intestine, lung, CNS, and skin. Four of these patients died from gastrointestinal complications of their disease. We conclude that unilateral ulcerative or hemorrhagic polypoid mucosal lesions in the sinonasal area are suggestive of lymphoma rather than WG, and nonspecific symptoms, at least in Western patients, may be present as early as the second or third decade of life. A biopsy specimen containing T lymphocytes positive for the EBV ribonucleoprotein EBER1 on in situ hybridization offers reliable confirmation of T-cell lymphoma and is of differential diagnostic value against WG.

Wegener’s granulomatosis: a new entity in the growing differential diagnosis of Degos’ disease

2009 ◽  
Vol 34 (5) ◽  
pp. e1-e3 ◽  
Author(s):  
G. Guhl ◽  
B. Diaz-Ley ◽  
Y. Delgado ◽  
E. Daudén ◽  
J. Fraga ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Degos Disease

Misleading clinical features in Wegener's granulomatosis. A case report

1997 ◽  
Vol 111 (8) ◽  
pp. 746-748 ◽  
Author(s):  
Giovanni Almadori ◽  
Maurizio Trivelli ◽  
Emanuele Scarano ◽  
Gabriella Cadoni
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Features ◽  
Wegener’S Granulomatosis ◽  
Systemic Vasculitis ◽  
Wegener's Granulomatosis ◽  
Lung Tumour ◽  
Pathological Findings ◽  
Serous Otitis Media ◽  
Primary Lung Tumour

AbstractWegener's granulomatosis is a systemic vasculitis that may present with a Variety of findings and be difficult to diagnose. We report a case of a patient who presented with serous otitis media and subsequently developed a suspected primary lung tumour. Thoracotomy and pulmonary mass excision were required to establish the diagnosis. Otological manifestations of Wegener's granulomatosis, differential diagnosis, pathological findings and c-ANCA test role are discussed.

Fulminant Wegener’s granulomatosis with multiorgan dysfunction

Open Medicine ◽  
2008 ◽  
Vol 3 (1) ◽  
pp. 119-122
Author(s):  
Andreja Sinkovic ◽  
Artur Pahor
Keyword(s):  
Differential Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Correct Diagnosis ◽  
Serum Levels ◽  
Wegener's Granulomatosis ◽  
Proteinase 3 ◽  
Kidney Dysfunction ◽  
Multiorgan Dysfunction ◽  
Lung And Kidney ◽  
Severe Lung

AbstractFulminant cases of Wegener’s granulomatosis (WG) with severe lung and kidney dysfunction may resemble pneumonia with sepsis and multiorgan dysfunction. Increased serum levels of antineutrophyl citoplasmic autoantibodies (c-ANCA) and proteinase 3 antibodies (PR3) confirm the correct diagnosis and are essential to start early immunosupressive treatment to improve the outcome. With the emphasis on diagnostic dilemmas, we present a 61-year old patient with fulminant WG, resembling pneumonia with sepsis and multiorgan dysfunction. After antibiotics and supportive measures increased serum levels of c-ANCA and PR3 confirmed the suspicion of WG and adequate immunosupressive treatment improved the patient’s condition. We concluded that it is important to include vasculitis in the differential diagnosis of unexplained multiorgan dysfunction, because only early adequate immunosuppressive therapy in combination with other resuscitation measures improves survival.

Salivary gland involvement in Wegener's granulomatosis

1990 ◽  
Vol 104 (3) ◽  
pp. 259-261 ◽  
Author(s):  
G. E. Murty ◽  
B. T. Mains ◽  
M. K. Bennett
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Medical Treatment ◽  
Wegener’S Granulomatosis ◽  
Wegener's Granulomatosis ◽  
Salivary Gland Enlargement ◽  
Gland Enlargement

AbstractWhen salivary gland enlargement occurs in association with other ENT symptoms, Wegener's granulomatosis should be considered in the differential diagnosis. An early anti-neutrophil cytoplasmic antibody (ANCA) test may aid diagnosis. Effective medical treatment exists and, once the diagnosis has been made, therapeutic excision of the affected gland may be unnecessary. The fourth and fifth cases in the literature of salivary gland involvement in Wegener's granulomatosis are reported.

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