scholarly journals Coexistence of myelodysplastic syndrome and acute megakaryoblastic leukemia: An aggressive disease

2021 ◽  
Author(s):  
Ganesh Kasinathan ◽  
Bee Sun Lee
Keyword(s):  
Myelodysplastic Syndrome ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Aggressive Disease

scholarly journals Transformation of myelodysplastic syndrome to acute megakaryoblastic leukemia: An aggressive disease

2020 ◽  
Author(s):  
Ganesh Kasinathan ◽  
Bee Sun Lee
Keyword(s):  
Lactate Dehydrogenase ◽  
Myelodysplastic Syndrome ◽  
Induction Chemotherapy ◽  
Poor Response ◽  
Intensive Chemotherapy ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Aggressive Disease ◽  
Disease Biology ◽  
High Lactate

A 59-year old gentleman with transformation of myelodysplastic syndrome to acute megakaryoblastic leukemia was treated with standard intensive chemotherapy. His poor outcome was attributed to advanced age, aggressive disease biology, underlying myelodysplastic syndrome, poor response to induction chemotherapy, high lactate dehydrogenase and lack of good cytogenetic and molecular mutations.

Childhood myelodysplastic syndrome with clonal evolution progressing to acute megakaryoblastic leukemia (ANLL-M7)

1993 ◽  
Vol 70 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Hiroyuki Tsuchiya ◽  
Yasuhiko Kaneko ◽  
Seiji Seguchi ◽  
Yuko Matsui ◽  
Takaharu Matsuyama ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Clonal Evolution ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia

Complex Karyotype and N-RAS Point Mutation in a Case of Acute Megakaryoblastic Leukemia (M7) Following a Myelodysplastic Syndrome

2000 ◽  
Vol 117 (2) ◽  
pp. 104-107 ◽  
Author(s):  
Teresa de Souza Fernandez ◽  
Maria Helena Ornellas ◽  
Luize Otero de Carvalho ◽  
Maria Christina Maioli ◽  
Stella Beatriz Gonçalves de Lucena ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Point Mutation ◽  
Complex Karyotype ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia

scholarly journals ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells

Blood ◽  
2009 ◽  
Vol 113 (14) ◽  
pp. 3337-3347 ◽  
Author(s):  
Monika J. Stankiewicz ◽  
John D. Crispino
Keyword(s):  
Human Cancer ◽  
Fetal Liver ◽  
Chromosome 21 ◽  
Wild Type ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Human Chromosome 21 ◽  
Ets Proteins ◽  
Differentiation Block ◽  
Stat Pathway

Abstract ETS2 and ERG are transcription factors, encoded on human chromosome 21 (Hsa21), that have been implicated in human cancer. People with Down syndrome (DS), who are trisomic for Hsa21, are predisposed to acute megakaryoblastic leukemia (AMKL). DS-AMKL blasts harbor a mutation in GATA1, which leads to loss of full-length protein but expression of the GATA-1s isoform. To assess the consequences of ETS protein misexpression on megakaryopoiesis, we expressed ETS2, ERG, and the related protein FLI-1 in wild-type and Gata1 mutant murine fetal liver progenitors. These studies revealed that ETS2, ERG, and FLI-1 facilitated the expansion of megakaryocytes from wild-type, Gata1-knockdown, and Gata1s knockin progenitors, but none of the genes could overcome the differentiation block characteristic of the Gata1-knockdown megakaryocytes. Although overexpression of ETS proteins increased the proportion of CD41+ cells generated from Gata1s-knockin progenitors, their expression led to a significant reduction in the more mature CD42 fraction. Serial replating assays revealed that overexpression of ERG or FLI-1 immortalized Gata1-knockdown and Gata1s knockin, but not wild-type, fetal liver progenitors. Immortalization was accompanied by activation of the JAK/STAT pathway, commonly seen in megakaryocytic malignancies. These findings provide evidence for synergy between alterations in GATA-1 and overexpression of ETS proteins in aberrant megakaryopoiesis.

scholarly journals Comprehensive analysis of gene alterations in acute megakaryoblastic leukemia of Down's syndrome

Leukemia ◽  
2003 ◽  
Vol 17 (11) ◽  
pp. 2250-2252 ◽  
Author(s):  
Y Hirose ◽  
K Kudo ◽  
H Kiyoi ◽  
Y Hayashi ◽  
T Naoe ◽  
...  
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Comprehensive Analysis ◽  
Acute Megakaryoblastic Leukemia ◽  
Megakaryoblastic Leukemia ◽  
Gene Alterations
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