scholarly journals Induction of long‐term glycemic control in a type 2 diabetic patient for 11 years by intensive lifestyle intervention

2020 ◽  
Author(s):  
Qianying Ou ◽  
Chaoping Cen ◽  
Cunxia Fan ◽  
Lu Lin ◽  
Fei Wang ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Diabetic Patient ◽  
Lifestyle Intervention ◽  
Intensive Lifestyle Intervention ◽  
Type 2 Diabetic

scholarly journals Effect of an Intensive Lifestyle Intervention on Glycemic Control in Patients With Type 2 Diabetes

JAMA ◽  
2017 ◽  
Vol 318 (7) ◽  
pp. 637 ◽  
Author(s):  
Mette Yun Johansen ◽  
Christopher Scott MacDonald ◽  
Katrine Bagge Hansen ◽  
Kristian Karstoft ◽  
Robin Christensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Lifestyle Intervention ◽  
Intensive Lifestyle Intervention

scholarly journals The effect of short-term intensive insulin therapy in newly-diagnosed Type-2 diabetic patients

2021 ◽  
Vol 37 (7) ◽  
Author(s):  
Cengiz Karacaer ◽  
Taner Demirci ◽  
Hasret Cengiz ◽  
Ceyhun Varim ◽  
Ali Tamer
Keyword(s):  
Glycemic Control ◽  
Insulin Therapy ◽  
Intensive Insulin Therapy ◽  
Diabetic Patients ◽  
Newly Diagnosed ◽  
Short Term ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objectives: We aimed to determine the effect of short-term intensive insulin therapy (SIIT) on long-term glycemic control in newly-diagnosed Type-2 diabetes mellitus (nT2DM) patients. Methods: In this retrospectively study conducted at Sakarya University Medical Faculty Training and Research Hospital Outpatient Clinic between 2016 and 2019, 65 nT2DM patients were enrolled soon after their SIIT was initiated and were followed for at least a year. Intensive insulin treatment was discontinued after three or 12 months in a total of 65 (23–73-year-old) patients who had been newly diagnosed with T2DM. Intensive insulin therapy was discontinued when glycemic control and the target Glycated Hemoglobin (HbA1c) level had been attained, after which oral anti-diabetic drug (OAD), long-term insulin, and diet therapies were pursued. Results: There was a significant decrease in mean HbA1c from 11.25±1.96% to 6.67±1.07%. Fasting plasma glucose (FPG) was found to be an independent predictor of whether intensive insulin therapy could be discontinued after three months in a model that included FPG, HbA1c, and body mass index measured at baseline. Patients with FPG >13.8 mmol/L were 7.6 times more likely to require intensive insulin therapy beyond three months. There were significant decreases in HbA1c and low-density lipoprotein-cholesterol concentration, but no change in C-peptide between baseline and 3 months of therapy. Conclusion: These results demonstrate that in nT2DM patients, intensive insulin therapy could be effective on long-term glycemic control and high FPG prior to three months of SIIT may predict poor long-term glycemic control. doi: https://doi.org/10.12669/pjms.37.7.4013 How to cite this:Karacaer C, Demirci T, Cengiz H, Varim C, Tamer A. The effect of short-term intensive insulin therapy in newly-diagnosed Type-2 diabetic patients. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.4013 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Long-term ketogenic diet contributes to glycemic control but promotes lipid accumulation and hepatic steatosis in type 2 diabetic mice

2016 ◽  
Vol 36 (4) ◽  
pp. 349-358 ◽  
Author(s):  
Xiaoyu Zhang ◽  
Juliang Qin ◽  
Yihan Zhao ◽  
Jueping Shi ◽  
Rong Lan ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Hepatic Steatosis ◽  
Ketogenic Diet ◽  
Lipid Accumulation ◽  
Diabetic Mice ◽  
Type 2 Diabetic
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