scholarly journals A rare case of hypercalcemic encephalopathy from ectopic secretion of parathyroid hormone

2020 ◽  
Vol 8 (3) ◽  
pp. 423-425
Author(s):  
Franchesca Gabrielle Concha Gabriel ◽  
Rosalina Espiritu Picar
Keyword(s):  
Parathyroid Hormone ◽  
Rare Case ◽  
Ectopic Secretion

Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone

2021 ◽  
Vol 50 (4) ◽  
pp. 683-709
Author(s):  
Filomena Cetani ◽  
Elena Pardi ◽  
Claudio Marcocci
Keyword(s):  
Parathyroid Hormone ◽  
Parathyroid Carcinoma ◽  
Ectopic Secretion

A Rare Case of Chronic Lymphocytic Leukemia with Hypercalcemia Induced by Elevated Parathyroid Hormone-Related Peptides

2010 ◽  
Vol 124 (1) ◽  
pp. 57-60 ◽  
Author(s):  
T. Kampfenkel ◽  
A. Baraniskin ◽  
C. Teschendorf ◽  
W. Schmiegel ◽  
G. Massenkeil
Keyword(s):  
Parathyroid Hormone ◽  
Chronic Lymphocytic Leukemia ◽  
Rare Case ◽  
Lymphocytic Leukemia

scholarly journals A Case of Von Hippel–Lindau Disease with Bilateral Pheochromocytoma and Ectopic Hypersecretion of Intact Parathyroid Hormone in an Adolescent Girl

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Rym Belaid ◽  
Ibtissem Oueslati ◽  
Melika Chihaoui ◽  
Meriem Yazidi ◽  
Wafa Grira ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Adrenal Tumors ◽  
Intact Parathyroid Hormone ◽  
Intact Pth ◽  
High Accumulation ◽  
Von Hippel Lindau ◽  
Ectopic Secretion ◽  
Bilateral Pheochromocytoma ◽  
Von Hippel Lindau Disease

Von Hippel–Lindau disease is an autosomal dominant inherited syndrome predisposing to a variety of highly vascularised tumors in different organs. Although bilateral pheochromocytoma was reported in patients with von Hippel–Lindau disease, the coexistence of primary hyperparathyroidism is not a common condition. We report an observation of a primary hyperparathyroidism secondary to an ectopic secretion of intact parathyroid hormone in a 17-year-old girl with von Hippel–Lindau disease and bilateral pheochromocytoma. She presented with a newly diagnosed diabetes mellitus and a severe arterial hypertension. Blood tests disclosed hypercalcemia with increased intact PTH level. Cervical ultrasound and sestamibi scintigraphy were normal. Twenty-four-hour urinary normetanephrine level was highly elevated pointing to a catecholamine-secreting tumor. The abdominal computed tomography showed bilateral adrenal masses. MIBG scintigraphy exhibited a high accumulation of the tracer in both adrenal tumors. Genetic testing revealed a mutation of the VHL gene. The patient underwent a bilateral adrenalectomy. The postoperative outcome was marked by normalization of blood pressure, blood glucose, calcium, and PTH levels. In our case, the elevation of intact PTH and its spontaneous normalization after surgical treatment of pheochromocytomas confirms its ectopic secretion.

scholarly journals A rare case of a parathyroid adenoma inside a parathyroid cyst

2014 ◽  
Vol 58 (7) ◽  
pp. 776-778 ◽  
Author(s):  
Spyridon N. Karras ◽  
Ioannis Koutelidakis ◽  
Panagiotis Anagnostis ◽  
Gesthimani Mintziori ◽  
Nikolaos Pontikides ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Parathyroid Adenoma ◽  
Therapeutic Approach ◽  
Rare Case ◽  
Cervical Lesions ◽  
Parathyroid Cyst ◽  
Parathyroid Cysts

Parathyroid cysts (PCs) are rare lesions, located in the neck and anterior mediastinal region. The vast majority are non-functioning, presented as nodular cervical lesions. Large, non-functioning PCs can manifest with compressive symptoms of the surrounding tissues. Rarely, PCs produce excessive amounts of parathyroid hormone (PTH), resulting in primary hyperparathyroidism. We report a case of functional PC, describing its diagnostic and therapeutic approach.

Rare case of pancreatic neuroendocrine tumour presenting as paraneoplastic hypercalcaemia

2021 ◽  
Vol 14 (4) ◽  
pp. e240786
Author(s):  
Benjamin Ferrel ◽  
Jan Franko ◽  
May C Tee
Keyword(s):  
Parathyroid Hormone ◽  
Surgical Management ◽  
Rare Case ◽  
Neuroendocrine Tumours ◽  
Neuroendocrine Tumour ◽  
Related Peptide ◽  
Pancreatic Neuroendocrine Tumours ◽  
Successful Removal ◽  
Pancreatic Neuroendocrine Tumour ◽  
Parathyroid Hormone Related Peptide

An asymptomatic 68-year-old woman who presented with an isolated hypercalcaemia was diagnosed with a rare, previously unsuspected parathyroid hormone-related peptide (PTHrP)-producing pancreatic neuroendocrine tumour. She underwent an extensive operation including vascular resection and reconstruction, resulting in successful removal of the tumour with negative margins. Medical and surgical management of pancreatic neuroendocrine tumours and PTHrP-mediated paraneoplastic hypercalcaemia is discussed.

A Case of Sporadic Pseudohypoparathyroidism Type 1B Presented with Hypokalemia

2021 ◽  
Author(s):  
Wen-jun Yang ◽  
Qin Zhang ◽  
Ping Jin
Keyword(s):  
Parathyroid Hormone ◽  
Rare Case ◽  
Autosomal Dominant ◽  
Molecular Level ◽  
Differentially Methylated Regions ◽  
Uniparental Isodisomy

Dear EditorLuo et al. 1 reported two cases of autosomal dominant pseudohypoparathyroidism type 1B (AD-PHP1B) and reviewed literature about the genetic and epigenetic characteristics of AD-PHP1B. Pseudohypoparathyroidism (PHP) is a cluster of heterogeneous diseases characterized by hypocalcemia and hyperphosphatemia due to resistance to parathyroid hormone (PTH). PHP1B almost results from methylation abnormalities of the maternal differentially methylated regions (DMRs) and can be divided into sporadic PHP1B and AD-PHP1B 1. As mentioned in this article 1, AD-PHP1B is caused by heterozygous maternal deletions within GNAS or STX16, which are associated with loss of methylation at the A/B DMR alone or at all maternally methylated GNAS exons. While sporadic PHP1B remains unclear at the molecular level, except for approximately 10% of the patients caused by paternal uniparental isodisomy or heterodisomy involving chromosome 20q (patUPD20q) 2. Here, we would like to present a rare case of sporadic PHP1B occurring in association with hypokalemia.

scholarly journals Ectopic secretion of parathyroid hormone by a renal adenocarcinoma in a patient with hypercalcaemia.

BMJ ◽  
1970 ◽  
Vol 4 (5737) ◽  
pp. 724-726 ◽  
Author(s):  
R. M. Buckle ◽  
M. McMillan ◽  
C. Mallinson
Keyword(s):  
Parathyroid Hormone ◽  
Renal Adenocarcinoma ◽  
Ectopic Secretion

scholarly journals Parathyroid Carcinoma Manifesting as Recurrent Nephrolithiasis

2015 ◽  
Vol 30 (1) ◽  
pp. 54-58
Author(s):  
Ma. Melizza S. Villalon ◽  
Celso V. Ureta
Keyword(s):  
Parathyroid Hormone ◽  
Parathyroid Carcinoma ◽  
Rare Case ◽  
Elevated Serum ◽  
Parathyroid Scintigraphy ◽  
Parathyroid Tumor ◽  
Neck Ultrasound ◽  
Complete Surgical Excision ◽  
Focal Uptake ◽  
Recurrent Nephrolithiasis

Objective: To present a rare case of primary parathyroid carcinoma and discuss its clinical findings and management. Methods: Study Design:             Case Report Setting:                        Tertiary Government Hospital Patient:                        One Results: A 54-year-old woman presented with a 3-year history of recurrent nephrolithiasis despite several courses of shock wave lithotripsy. She had persistent hypercalcemia and parathyroid hormone levels were noted to be elevated. Neck ultrasound showed a hypoechoic solid nodule measuring approximately 1.7 x 1.6 cm in the lateral inferoposterior aspect of the left thyroid lobe. Parathyroid scintigraphy revealed a focal uptake on the left lower thyroidal bed. The patient underwent left inferior parathyroidectomy with subtotal thyroidectomy and isthmusectomy Frozen section reported a parathyroid tumor and the final histopathologic results revealed a parathyroid carcinoma. Conclusion: A rare case of parathyroid carcinoma was presented, manifesting with recurrent nephrolithiasis. Elevated serum calcium and intact parathyroid hormone (iPTH) can confirm a primary hyperparathyroid problem. Neck ultrasound and parathyroid scintigraphy help in the localization of a parathyroid tumor. Only final histopathologic results can confirm the diagnosis of parathyroid carcinoma. Complete surgical excision is the treatment of choice and offers a good prognosis. Keywords: Parathyroid carcinoma, primary hyperparathyroidism

scholarly journals A case of motor and sensory polyneuropathy induced by primary hyperparathyroidism

2021 ◽  
Vol 23 (2) ◽  
pp. 134-137
Author(s):  
Mina Lee ◽  
Hye Jeong Kim ◽  
Hakjae Roh
Keyword(s):  
Nervous System ◽  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Muscle Weakness ◽  
Rare Case ◽  
Major Influence ◽  
Proximal Muscle Weakness ◽  
Proximal Muscle ◽  
Muscle Cramps ◽  
Sensory Polyneuropathy

Primary hyperparathyroidism (PHP) is a disease in which excessive amounts of parathyroid hormone (PTH) are secreted and calcium levels in the blood increase. Hypercalcemia caused by PHP has a major influence on the peripheral nervous system and produces symptoms such as muscle cramps, paresthesia, and proximal muscle weakness. Here we report a rare case of sensory-dominant polyneuropathy caused by PHP, which improved after surgery.

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