scholarly journals Venetoclax with high‐dose methotrexate and rituximab seem effective and well‐tolerated in the treatment of central nervous system involvement of chronic lymphocytic leukemia: A case report

2020 ◽  
Vol 8 (2) ◽  
pp. 269-273
Author(s):  
Guillaume Beziat ◽  
Martin Gauthier ◽  
Caroline Protin ◽  
Lucie Oberic ◽  
Fleur Lerebours ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Chronic Lymphocytic Leukemia ◽  
Central Nervous System Involvement ◽  
Lymphocytic Leukemia ◽  
High Dose ◽  
High Dose Methotrexate ◽  
System Involvement ◽  
Dose Methotrexate

scholarly journals Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Nicolas Gallastegui ◽  
Daniel P. Cassidy ◽  
Deborah O. Heros ◽  
Francisco Vega ◽  
Jonathan H. Schatz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Lymphocytic Leukemia ◽  
Chemotherapy Regimen ◽  
Central Nervous System Involvement ◽  
Lymphocytic Leukemia ◽  
High Dose ◽  
Sustained Remission ◽  
Small Lymphocytic Lymphoma ◽  
System Involvement

Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebrovascular accident related to a cardiac myxoma, who developed parenchymal central nervous system involvement of lymphoma on the ischemic bed. The patient was successfully treated with a high-dose fludarabine-based chemotherapy regimen, achieving a sustained remission. We propose that embolic breakage of the blood-brain barrier may be a major risk factor in producing central nervous system involvement. We also propose that a high-dose fludarabine-based chemotherapy regimen may be adequate to achieve a better CNS penetration and improved outcomes.

scholarly journals Successful Treatment of Chronic Lymphocytic Leukemia Multifocal Central Nervous System Involvement with Ibrutinib

2018 ◽  
Vol 35 (2) ◽  
pp. 147-149
Author(s):  
Anna Christoforidou ◽  
Georgios Kapsas ◽  
Zoe Bezirgiannidou ◽  
Spyros Papamichos ◽  
Ioannis Kotsianidis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Lymphocytic Leukemia ◽  
Successful Treatment ◽  
Central Nervous System Involvement ◽  
Lymphocytic Leukemia ◽  
System Involvement

scholarly journals Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia

Haematologica ◽  
2016 ◽  
Vol 101 (4) ◽  
pp. 458-465 ◽  
Author(s):  
Paolo Strati ◽  
Joon H. Uhm ◽  
Timothy J. Kaufmann ◽  
Chadi Nabhan ◽  
Sameer A. Parikh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Lymphocytic Leukemia ◽  
Central Nervous System Involvement ◽  
Lymphocytic Leukemia ◽  
System Involvement
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