scholarly journals Fluorescent light energy: A new therapeutic approach to effectively treating acne conglobata and hidradenitis suppurativa

2019 ◽  
Vol 7 (9) ◽  
pp. 1769-1772 ◽  
Author(s):  
Ikonija Koceva ◽  
Bettina Rümmelein ◽  
Peter Arne Gerber ◽  
Deirdre Edge ◽  
Michael Canova Engelbrecht Nielsen
Keyword(s):  
Therapeutic Approach ◽  
Hidradenitis Suppurativa ◽  
Light Energy ◽  
Fluorescent Light ◽  
Acne Conglobata

Implications of Hidradenitis Suppurativa Phenotypes in Cardiovascular Risk and Treatment Decisions: A Retrospective Cohort Study

Dermatology ◽  
2021 ◽  
pp. 1-6
Author(s):  
Carlos Cuenca-Barrales ◽  
Trinidad Montero-Vilchez ◽  
Luis Salvador-Rodríguez ◽  
Manuel Sánchez-Díaz ◽  
Salvador Arias-Santiago ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cardiovascular Risk ◽  
Disease Severity ◽  
Retrospective Cohort Study ◽  
Therapeutic Approach ◽  
Retrospective Cohort ◽  
Hidradenitis Suppurativa ◽  
Severe Disease ◽  
Treatment Decisions ◽  
Lesion Pattern

<b><i>Background:</i></b> New integrative hidradenitis suppurativa (HS) lesion pattern phenotypes have been proposed, an inflammatory phenotype (IP) and a follicular phenotype (FP). They are characterized by different lesion patterns, symptoms, and risks of disease progression. <b><i>Objectives:</i></b> To evaluate whether lesion pattern phenotypes (1) have a different cardiovascular risk factor profile, and (2) are associated with a different therapeutic approach in the setting of an HS clinic. <b><i>Methods:</i></b> A retrospective cohort study was conducted on 233 patients with HS. They were classified according to lesion pattern phenotype criteria. Data regarding cardiovascular risk factors and treatment decisions were gathered. <b><i>Results:</i></b> One hundred and seventeen HS patients (50.21%) were classified as FP and 112 (48.07%) as IP. IP was associated with more severe disease and greater impairment of quality of life. Regardless of disease severity, patients with IP may have a higher cardiovascular risk, assessed according to higher C-reactive protein (CRP) levels (12.75 vs. 5.89, <i>p</i> = 0.059). The lesion pattern phenotype also influenced treatment decisions regardless of disease severity. Patients with IP were more likely to be treated with systemic corticosteroids and adalimumab, showing that lesion pattern phenotypes are associated with different therapeutic approaches. <b><i>Conclusions:</i></b> IP is associated with higher CRP values, suggesting a greater cardiovascular risk in these patients and also a different therapeutic approach. This information could help guide dermatologists in the management of HS patients and help to determine future treatment recommendations.

THE INFLUENCE OF THE RATIO OF INCANDESCENT TO FLUORESCENT LIGHT ON THE FLOWERING RESPONSE OF MARQUIS WHEAT GROWN UNDER CONTROLLED CONDITIONS

1961 ◽  
Vol 41 (2) ◽  
pp. 418-427 ◽  
Author(s):  
D. J. C. Friend ◽  
V. A. Helson ◽  
J. E. Fisher
Keyword(s):  
Stem Elongation ◽  
High Light ◽  
Light Energy ◽  
Fluorescent Light ◽  
Floral Initiation ◽  
Incandescent Light ◽  
Flowering Response ◽  
Controlled Conditions ◽  
Floral Differentiation ◽  
Plant Level

When Marquis wheat is grown under artificial conditions, the main light energy (lamp watts) supplied by fluorescent light should be supplemented by at least 35 per cent of incandescent light in order to have a photoperiodic effect close to the maximal. Increasing the percentage up to 100 per cent resulted in slightly earlier flowering. This effect of incandescent light was caused, not by earlier floral initiation, but by an increase in the rate of stem elongation and a hastening of the later stages of floral differentiation. This action of incandescent light could not be replaced by substituting pink fluorescent for one-third of the white fluorescent lights.To obtain a photoperiodic effect equal to that of high light energy from combined fluorescent and incandescent bulbs, it is recommended that the daylength be extended by sufficient incandescent light to give an intensity of at least 50 ft.-c. at plant level.

scholarly journals Acne Conglobata Associated with Hidradenitis Suppurativa, Disorders of Follicular Occlusion (Case Report)

2015 ◽  
Vol 15 (2) ◽  
pp. 30-34
Author(s):  
K. Pecova
Keyword(s):  
Hidradenitis Suppurativa ◽  
Severe Form ◽  
Term Treatment ◽  
Acne Conglobata ◽  
Long Term Treatment ◽  
Associated Symptoms ◽  
History Of ◽  
Inflammatory Bowel ◽  
Prepubertal Age

Abstract The author is presenting the case of a 23-year-old female patient with a severe form of acne conglobata, with the first symptoms of the disease occurring as far back as the prepubertal age. In the past year the disease has combined with hidradenitis suppurativa (to be referred to henceforth as “HS”), Hurley stage I, in the axillae and both sides of the inguinal region, with a family history of acne conglobata (both her mother and brother were affected). Further examinations ruled out inflammatory bowel disease because of a lack of further associated symptoms, except for sideropenic anaemia (lesser form) and lower serum values of vitamin D. Up until now the disease has been resistant to treatment, including the long-term treatment of methylprednisolone in combination with isotretinoid as well as dapsone and antibiotics.

Hidradenitis Suppurativa and Zinc: A New Therapeutic Approach

Dermatology ◽  
2007 ◽  
Vol 214 (4) ◽  
pp. 325-327 ◽  
Author(s):  
Anabelle Brocard ◽  
Anne-Chantal Knol ◽  
Amir Khammari ◽  
Brigitte Dréno
Keyword(s):  
Therapeutic Approach ◽  
Hidradenitis Suppurativa

scholarly journals Topical 5-aminolevulinic acid photodynamic therapy improved refractory acne conglobata and perifolliculitis capitis abscedens et suffodiens rather than hidradenitis suppurativa

2016 ◽  
Vol 09 (01) ◽  
pp. 1640002 ◽  
Author(s):  
Linglin Zhang ◽  
Peiru Wang ◽  
Lei Shi ◽  
Guolong Zhang ◽  
Yunfeng Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hidradenitis Suppurativa ◽  
Aminolevulinic Acid ◽  
Life Quality ◽  
Poor Response ◽  
Acne Conglobata ◽  
Good Improvement ◽  
Acne Treatment ◽  
Response Formula

Acne conglobata (AC), perifolliculitis capitis abscedens et suffodiens (PCAS) and hidradenitis suppurativa (HS) are uncommon refractory chronic, inflammatory, scarring diseases but cause serious damage to the quality of life. These three diseases are associated with follicular occlusion. Several studies indicated topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT) improved follicular occlusion besides acne treatment. So we attempted to apply ALA-PDT to medicine resistant AC, PCAS and HS. Topical ALA-PDT was applied to 10 patients with AC, seven patients with PCAS and three patients with HS for more than three sessions. All the patients completed the dermatology life quality index (DLQI) questionnaire and were assessed for the efficacy at the baseline and on two weeks after each treatment. Adverse effects were recorded at each visit. The results showed 25.5% (5/20, two cases of AC and three cases of PCAS) of patients achieved excellent improvement after three sessions of PDT and another 60.0% (12/20, eight cases of AC and four cases of PCAS) of patients achieved good improvement. 15.0% (3/20, three cases of HS) got poor response ([Formula: see text] 20% lesions clearance). Another five cases (three cases of AC and two cases of PCAS) also achieved excellent response after 5–7 sessions of PDT. We also found that papular/nodular, cyst/abscess showed higher clearance rate than sinus/fistula (88.5%, 86.1% versus 11.1%). DLQI was reduced after three sessions of PDT in AC and PCAS patients rather than HS patients. 5-ALA-PDT could improve refractory AC and PCAS but could not lead to improvement in late stage of HS. The efficacy increased with more treatment sessions.

scholarly journals Evaluation of Fluorescent Light Energy for the Treatment of Acute Second-degree Burns

2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 416-423
Author(s):  
Maiken Mellergaard ◽  
Stéphane Fauverghe ◽  
Carlotta Scarpa ◽  
Vladimir Luca Pozner ◽  
Søren Skov ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Ex Vivo ◽  
Visible Spectrum ◽  
Skin Inflammation ◽  
Light Energy ◽  
Fluorescent Light ◽  
Skin Model ◽  
Randomized Controlled Clinical Trials ◽  
Second Degree

ABSTRACT Introduction The use of photobiomodulation has been proposed to improve wound healing for the last two decades. Recent development in photobiomodulation has led to the development of a novel biophotonic platform that utilizes fluorescent light energy (FLE) within the visible spectrum of light for healing of skin inflammation and wounds. Materials and Methods In this article, FLE was used in preliminary analysis on 18 case studies of acute second-degree burns and in a pilot study using an ex vivo human skin model. Efficacy of FLE on wound healing and tissue remodeling was evaluated by monitoring improvements in the treated tissues, assessing pain for the patients, and by performing human genome microarray analysis of FLE-treated human skin samples. Results Healing was reported for all 18 patients treated with FLE for acute second-degree burns without reported adverse effects or development of infections. Furthermore, preliminary ex vivo skin model data suggest that FLE impacts different cellular pathways including essential immune-modulatory mechanisms. Conclusions The results presented in this article are encouraging and suggest that FLE balances different stages of wound healing, which opens the door to initiating randomized controlled clinical trials for establishing the efficacy of FLE treatment in different phases of wound healing of second-degree burns.

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