scholarly journals Bone marrow necrosis in neuroendocrine tumor of the thymus

2018 ◽  
Vol 6 (10) ◽  
pp. 1970-1971
Author(s):  
Benoît Ducourneau ◽  
Claire Hemar
Keyword(s):  
Bone Marrow ◽  
Neuroendocrine Tumor ◽  
Bone Marrow Necrosis

Bone marrow necrosis and fat embolism syndrome: a near fatal complication in previously undiagnosed sickle beta + thalassaemia

2021 ◽  
Vol 14 (1) ◽  
pp. e238317
Author(s):  
Nibash Budhathoki ◽  
Sunita Timilsina ◽  
Bebu Ram ◽  
Douglas Marks
Keyword(s):  
Bone Marrow ◽  
Multiorgan Failure ◽  
Rare Condition ◽  
Altered Mental Status ◽  
Fat Embolism ◽  
Bone Marrow Necrosis ◽  
Embolism Syndrome ◽  
Hb S ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Prevalence of haemoglobin sickle-β+ thalassaemia (Hb S/β+thal) is variable with geography ranging from 0.2% to 10% among sickle cell patients. Clinical presentation of Hb S/β+thal patients depends on HbA level, with milder disease often going undiagnosed. However, rarely these patients can present with a fulminant vaso-occlusive crisis (VOC). Given VOC can present with non-specific symptoms, the diagnosis and treatment is often delayed. Here, we present a patient who initially developed altered mental status, pancytopenia and multiorgan failure due a critical VOC resulting in bone marrow necrosis and fat embolism. Subsequent workup confirmed that our patient had Sickle-β+ thalassaemia, which had gone undiagnosed, despite subclinical evidence of haemolysis on routine lab work for years. Following diagnosis and initiation of RBC exchange, he improved significantly and was discharged home. High index of suspicion and bone marrow biopsy is vital for early diagnosis and management of this rare condition.

scholarly journals Clostridium haemolyticum Infection: A Cause of Hemolytic Anemia in a Patient with Bone Marrow Necrosis

2021 ◽  
Vol 9 (8) ◽  
pp. 1568
Author(s):  
Anne Sophie Lagneaux ◽  
Sandrine Hénard ◽  
Laure Diancourt ◽  
Emmanuelle Stein ◽  
Pierre Perez ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hemolytic Anemia ◽  
Obese Woman ◽  
Molecular Techniques ◽  
Significant Past Medical History ◽  
Bone Marrow Necrosis ◽  
Rdna Sequencing ◽  
Oxygen Sensitive ◽  
Bacteremic Episode ◽  
Bone Marrow Regeneration

Clostridium haemolyticum is a sporulating Gram-positive anaerobic rod that is considered to be one of the most fastidious and oxygen-sensitive anaerobes. It is a well-known animal pathogen and the cause of bacillary hemoglobinuria primarily in cattle. To date, human infections caused by C. haemolyticum have been reported in three patients with malignant underlying diseases. We present herein the case of a 30-year-old obese woman with no significant past medical history who developed bacteremia caused by C. haemolyticum with massive intravascular hemolysis associated with bone marrow necrosis and acute renal failure. Because of subculture failure, the diagnosis was made on the basis of 16S rDNA sequencing and next-generation sequencing. The patient, who had been afebrile for 20 days after a 17-day-course of antibiotics, experienced a second bacteremic episode caused by C. haemolyticum. After having been successfully treated for 42 days with clindamycin and amoxicillin-clavulanic acid, the patient developed acute myeloid leukemia as a result of bone marrow regeneration. Although uncommon in humans, infections caused by C. haemolyticum are severe and should be considered in a febrile patient who has severe hemolytic anemia. This case also highlights the importance of using molecular techniques for the identification of this fastidious anaerobic organism.

scholarly journals Evidence for complement-mediated bone marrow necrosis in a young adult with sickle cell disease

2021 ◽  
Vol 86 ◽  
pp. 102508
Author(s):  
Melissa Azul ◽  
Surbhi Shah ◽  
Sarah Williams ◽  
Gregory M. Vercellotti ◽  
Alexander A. Boucher
Keyword(s):  
Bone Marrow ◽  
Young Adult ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Bone Marrow Necrosis

scholarly journals Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome

Hematology ◽  
2000 ◽  
Vol 5 (2) ◽  
pp. 163-165 ◽  
Author(s):  
Tohru Murayama ◽  
Yoshitake Hayashi ◽  
Shion Imoto ◽  
Manabu Shimoyama ◽  
Hiroshi Matsuoka ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Necrosis ◽  
Polyclonal Hypergammaglobulinemia ◽  
Blue Toe Syndrome ◽  
Massive Bone

Bone Marrow Necrosis

2009 ◽  
Vol 214 (4) ◽  
pp. 331-336 ◽  
Author(s):  
PETER V. HANSEN ◽  
JØRN ANDERSEN ◽  
HENRIK MYGIND
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Necrosis

scholarly journals A Case of Malignant Lymphoma with Bone Marrow Necrosis

2008 ◽  
Vol 57 (2/3) ◽  
pp. 31-35
Author(s):  
Hiroko NAKABAYASHI ◽  
Manabu KONDO ◽  
Takayuki TOMINAGA ◽  
Kenji SHINOHARA ◽  
Toshiaki KAMEI
Keyword(s):  
Bone Marrow ◽  
Malignant Lymphoma ◽  
Bone Marrow Necrosis

Clostridium perfringens gangrenous cystitis with septic shock and bone marrow necrosis

2012 ◽  
Vol 38 (11) ◽  
pp. 1906-1907 ◽  
Author(s):  
C. Lazarescu ◽  
A. Kimmoun ◽  
A. Blatt ◽  
C. Bastien ◽  
B. Levy
Keyword(s):  
Bone Marrow ◽  
Septic Shock ◽  
Clostridium Perfringens ◽  
Bone Marrow Necrosis
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