scholarly journals Direct Factor X sequestration by systemic amyloid light-chain amyloidosis

2018 ◽  
Vol 6 (3) ◽  
pp. 513-515 ◽  
Author(s):  
Haruko Tashiro ◽  
Ryosuke Shirasaki ◽  
Masato Watanabe ◽  
Kazuo Kawasugi ◽  
Yoshihisa Takahashi ◽  
...  
Keyword(s):  
Light Chain ◽  
Factor X ◽  
Direct Factor ◽  
Light Chain Amyloidosis ◽  
Amyloid Light Chain

scholarly journals Use of ixazomib, lenalidomide and dexamethasone in patients with relapsed amyloid light‐chain amyloidosis

2020 ◽  
Vol 189 (4) ◽  
pp. 643-649 ◽  
Author(s):  
Oliver C. Cohen ◽  
Faye Sharpley ◽  
Julian D. Gillmore ◽  
Helen J. Lachmann ◽  
Sajitha Sachchithanantham ◽  
...  
Keyword(s):  
Light Chain ◽  
Light Chain Amyloidosis ◽  
Amyloid Light Chain

scholarly journals Prevalence and clinical implications of t(11;14) in patients with amyloid light-chain amyloidosis with or without concurrent multiple myeloma

2019 ◽  
Vol 49 (2) ◽  
pp. 195-198 ◽  
Author(s):  
Hiroki Kobayashi ◽  
Yoshiaki Abe ◽  
Daisuke Miura ◽  
Kentaro Narita ◽  
Akihiro Kitadate ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Clinical Implications ◽  
Light Chain Amyloidosis ◽  
Amyloid Light Chain

Estimating the Global Epidemiology of Amyloid Light-Chain Amyloidosis With an Incidence-to-Prevalence Model

2019 ◽  
Vol 19 (10) ◽  
pp. e339
Author(s):  
Nicole Zhang ◽  
Dasha Cherepanov ◽  
Dorothy Romanus ◽  
Nishant Kumar ◽  
Michael Hughes ◽  
...  
Keyword(s):  
Light Chain ◽  
Light Chain Amyloidosis ◽  
Global Epidemiology ◽  
Amyloid Light Chain

Systemic Amyloid Light‐chain amyloidosis with colonic involvement complicated by colo‐colic intussusception

2019 ◽  
Vol 90 (6) ◽  
pp. 1162-1163
Author(s):  
Hwee Leong Tan ◽  
Aik Yong Chok ◽  
Yihan Li ◽  
Wah Siew Tan
Keyword(s):  
Light Chain ◽  
Light Chain Amyloidosis ◽  
Colonic Involvement ◽  
Amyloid Light Chain

Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy

Blood ◽  
2001 ◽  
Vol 97 (6) ◽  
pp. 1885-1887 ◽  
Author(s):  
Elie B. Choufani ◽  
Vaishali Sanchorawala ◽  
Timothy Ernst ◽  
Karen Quillen ◽  
Martha Skinner ◽  
...  
Keyword(s):  
Light Chain ◽  
Medical Center ◽  
Bleeding Complications ◽  
Plasma Cell Dyscrasia ◽  
High Dose ◽  
Al Amyloidosis ◽  
Related Factor ◽  
Factor X ◽  
Factor X Deficiency ◽  
Amyloid Light Chain

Acquired deficiency of factor X occurs in patients with systemic amyloid light-chain (AL) amyloidosis, presumably due to adsorption of factor X to amyloid fibrils. Of 368 consecutive patients with systemic AL amyloidosis evaluated at Boston Medical Center, 32 patients (8.7%) had factor X levels below 50% of normal. Eighteen of these patients (56%) had bleeding complications, which were more frequent and severe in the 12 patients below 25% of normal; 2 episodes were fatal. Ten factor X–deficient patients received high-dose melphalan chemotherapy followed by autologous stem cell transplantation. Of 7 patients alive 1 year after treatment, 4 had a complete hematologic response, and all 4 experienced improvement in their factor X levels. One of 2 additional patients with partial hematologic responses had improvement in factor X. Thus, aggressive treatment of the underlying plasma cell dyscrasia in AL amyloidosis can lead to the amelioration of amyloid-related factor X deficiency.

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