scholarly journals Cutaneous lymphocyte antigen expression loss and PD1 positivity in early cutaneous lesions of rapidly progressive mycosis fungoides

2014 ◽  
Vol 2 (5) ◽  
pp. 209-218
Author(s):  
Olakunle Ogunrinade ◽  
Christine S. Ahn ◽  
Usama Gergis ◽  
Aminah H. Yassin ◽  
Cynthia Magro
Keyword(s):  
Mycosis Fungoides ◽  
Antigen Expression ◽  
Cutaneous Lesions ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen ◽  
Expression Loss

scholarly journals Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow.

1994 ◽  
Vol 127 (5) ◽  
pp. 1485-1495 ◽  
Author(s):  
R Alon ◽  
H Rossiter ◽  
X Wang ◽  
T A Springer ◽  
T S Kupper
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
Cell Surface ◽  
Antigen Expression ◽  
Lymphocyte Antigen ◽  
Selectin Ligands ◽  
Distinct Cell ◽  
Cutaneous Lymphocyte Antigen

Memory T lymphocytes extravasate at sites of inflammation, but the mechanisms employed by these cells to initiate contact and tethering with endothelium are incompletely understood. An important part of leukocyte extravasation is the initiation of rolling adhesions on endothelial selectins; such events have been studied in monocytes and neutrophils but not lymphocytes. In this study, the potential of T lymphocytes to adhere and roll on endothelial selectins in vitro was investigated. We demonstrate that T cells can form tethers and rolling adhesions on P selectin and E selectin under physiologic flow conditions. Tethering and rolling on P selectin was independent of cell-surface cutaneous lymphocyte antigen (CLA) expression, which correlated strictly with the capacity of T cells to form rolling adhesions under flow on E selectin. T cell tethering to P selectin was abolished by selective removal of cell surface sialomucins by a P. haemolytica O-glycoprotease, while cutaneous lymphocyte antigen expression was unaffected. A sialomucin molecule identical or closely related to P selectin glycoprotein ligand-1 (PSGL-1), the major P selectin ligand on neutrophils and HL-60 cells, appears to be a major T cell ligand for P selectin. P selectin glycoprotein ligand-1 does not appear to support T cell rolling on E selectin. In turn, E selectin ligands do not appear to be associated with sialomucins. These data demonstrate the presence of structurally distinct ligands for P or E selectins on T cells, provide evidence that both ligands can be coexpressed on a single T cell, and mediate tethering and rolling on the respective selectins in a mutually exclusive fashion.

scholarly journals Cutaneous lymphocyte antigen expression on human effector B cells depends on the site and on the nature of antigen encounter

2003 ◽  
Vol 33 (12) ◽  
pp. 3275-3283 ◽  
Author(s):  
Anu Kantele ◽  
Erkki Savilahti ◽  
Heidi Tiimonen ◽  
Katja Iikkanen ◽  
Soile Autio ◽  
...  
Keyword(s):  
B Cells ◽  
Antigen Expression ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

Near infrared photoimmunotherapy targeting the cutaneous lymphocyte antigen for mycosis fungoides

2020 ◽  
pp. 1-5
Author(s):  
Micol Silic-Benussi ◽  
Andrea Saponeri ◽  
Anna Michelotto ◽  
Irene Russo ◽  
Anna Colombo ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Near Infrared ◽  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen

scholarly journals Peptide Vaccination in Montanide Adjuvant Induces and GM-CSF Increases CXCR3 and Cutaneous Lymphocyte Antigen Expression by Tumor Antigen–Specific CD8 T Cells

2013 ◽  
Vol 1 (5) ◽  
pp. 332-339 ◽  
Author(s):  
Eleanor Clancy-Thompson ◽  
Laura K. King ◽  
Lenora D. Nunnley ◽  
Irene M. Mullins ◽  
Craig L. Slingluff ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Tumor Antigen ◽  
Antigen Expression ◽  
Peptide Vaccination ◽  
Lymphocyte Antigen ◽  
Gm Csf ◽  
Cutaneous Lymphocyte Antigen

Primary Cutaneous ALCL With Phosphorylated/Activated Cytoplasmic ALK and Novel Phenotype: EMA/MUC1+, Cutaneous Lymphocyte Antigen Negative

2008 ◽  
Vol 32 (9) ◽  
pp. 1421-1426 ◽  
Author(s):  
Marshall E. Kadin ◽  
Jack L. Pinkus ◽  
Geraldine S. Pinkus ◽  
Ivan H. Duran ◽  
Christine E. Fuller ◽  
...  
Keyword(s):  
Lymphocyte Antigen ◽  
Cutaneous Lymphocyte Antigen
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