Cell therapy for cardiac diseases

The scale of cardiac diseases, and in particular heart failure and acute myocardial infarction, emphasises the need for radically new approaches, such as cell therapy, to address the underlying cause of the disease, the loss of functional myocardium. Stem cell-based therapies, whether through transplanted cells or directing innate repair, may provide regenerative approaches to cardiac diseases by halting, or even reversing, the events responsible for progression of organ failure. Cardio3 BioSciences, a leading Belgian biotechnology company focused on the discovery and development of regenerative and protective therapies for the treatment of cardiac disease, was founded in this context in 2004. The company is developing a highly innovative cell therapy approach based on a platform designed to reprogramme the patient’s own stem cells into cardiac progenitor cells. The underlying rationale behind this approach is that, in order to reconstruct cardiac tissue, stem cells need to be specific to cardiac tissue. The key is therefore to provide cardiac-specific progenitor cells to the failing heart to induce cardiac repair.

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Stem cell therapy for cardiac diseases

Current Opinion in Hematology ◽

10.1097/01.moh.0000143359.77689.aa ◽

2004 ◽

Vol 11 (6) ◽

pp. 399-403 ◽

Cited By ~ 22

Author(s):

Emerson C Perin ◽

Guilherme V Silva

Keyword(s):

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Cardiac Diseases

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Human Pluripotent Stem Cell-Derived Cardiac Cells: Application in Disease Modeling, Cell Therapy, and Drug Discovery

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.655161 ◽

2021 ◽

Vol 9 ◽

Author(s):

Juan Huang ◽

Qi Feng ◽

Li Wang ◽

Bingying Zhou

Keyword(s):

Stem Cell ◽

Drug Discovery ◽

Cell Therapy ◽

Pluripotent Stem Cell ◽

Disease Modeling ◽

Three Dimensional ◽

Cardiac Cells ◽

Cardiac Diseases ◽

Human Pluripotent Stem Cell ◽

Species Specific

Cardiac diseases are the leading cause of deaths worldwide; however, to date, there has been limited progress in the development of therapeutic options for these conditions. Animal models have been the most extensively studied methods to recapitulate a wide variety of cardiac diseases, but these models exhibit species-specific differences in physiology, metabolism and genetics, which lead to inaccurate and unpredictable drug safety and efficacy results, resulting in drug attrition. The development of human pluripotent stem cell (hPSC) technology in theory guarantees an unlimited source of human cardiac cells. These hPSC-derived cells are not only well suited for traditional two-dimensional (2-D) monoculture, but also applicable to more complex systems, such as three-dimensional (3-D) organoids, tissue engineering and heart on-a-chip. In this review, we discuss the application of hPSCs in heart disease modeling, cell therapy, and next-generation drug discovery. While the hPSC-related technologies still require optimization, their advances hold promise for revolutionizing cell-based therapies and drug discovery.

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ACTUAL PROBLEMS OF CELL THERAPY FOR CARDIAC DISEASES

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v67i4.194 ◽

2012 ◽

Vol 67 (4) ◽

pp. 16-24

Author(s):

D. V. Gol'dshtein ◽

T. Kh. Fatkhudinov

Keyword(s):

Cell Therapy ◽

Cardiac Diseases

This article reviews the literatury and own dates of cell therapy for cardiac diseases. The principal unresolved issues were formulated.

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Cell Therapy in Cardiac Diseases

Introduction to Translational Cardiovascular Research ◽

10.1007/978-3-319-08798-6_30 ◽

2014 ◽

pp. 565-582

Author(s):

Vasileios Sousonis ◽

Konstantinos Malliaras ◽

John Terrovitis ◽

John Nanas

Keyword(s):

Cell Therapy ◽

Cardiac Diseases

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Stem Cell Therapy for Cardiac Diseases

Cardiovascular Medicine ◽

10.1007/978-1-84628-715-2_135 ◽

2007 ◽

pp. 2745-2769 ◽

Cited By ~ 2

Author(s):

Emerson C. Perin ◽

GuiL’Herme V. Silva ◽

James T. Willerson

Keyword(s):

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Cardiac Diseases

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FEATURES

Asia-Pacific Biotech News ◽

10.1142/s0219030312000183 ◽

2012 ◽

Vol 16 (03) ◽

pp. 20-46

Keyword(s):

Stem Cells ◽

Stem Cell ◽

Regenerative Medicine ◽

Cell Therapy ◽

Peripheral Nerve ◽

Neural Stem Cells ◽

Stem Cell Therapy ◽

Cardiac Diseases ◽

Peripheral Nerve Injuries ◽

Nerve Injuries

Expatriate Researcher Returns to Roost. Past, Present and Future of Stem Cells in Regenerative Medicine. Learning Human Cardiac Diseases through Stem Cells. Bioprocessing for Stem Cell Therapy: From the Lab into the Log Phase. Neural Stem Cells and Cell-based Approaches in Neurodegeneration and Peripheral Nerve Injuries. The Marketing of Unapproved Stem Cell Products: An Industry-wide Challenge.

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