scholarly journals Individual patient data analysis of the BIOFLOW study program comparing safety and efficacy of a bioresorbable polymer sirolimus eluting stent to a durable polymer everolimus eluting stent

2020 ◽  
Author(s):  
Ralph Toelg ◽  
Ton Slagboom ◽  
Johannes Waltenberger ◽  
Thierry Lefèvre ◽  
Shigeru Saito ◽  
...  
Keyword(s):  
Data Analysis ◽  
Individual Patient Data ◽  
Patient Data ◽  
Study Program ◽  
Safety And Efficacy ◽  
Durable Polymer ◽  
Bioresorbable Polymer ◽  
Sirolimus Eluting Stent

scholarly journals Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria: A Prospective Multi-Centre Individual Patient Data Analysis

PLoS ONE ◽  
2009 ◽  
Vol 4 (7) ◽  
pp. e6358 ◽  
Author(s):  
Julien Zwang ◽  
Elizabeth A. Ashley ◽  
Corine Karema ◽  
Umberto D'Alessandro ◽  
Frank Smithuis ◽  
...  
Keyword(s):  
Data Analysis ◽  
Falciparum Malaria ◽  
Individual Patient Data ◽  
Patient Data ◽  
Safety And Efficacy

scholarly journals MP37-07 INDIVIDUAL PATIENT DATA ANALYSIS IN RANDOMIZED CLINICAL TRIALS: IMPACT OF RACE ON PROSTATE CANCER OUTCOMES

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
Daniel Spratt ◽  
Yu-Wei Chen ◽  
Brandon Mahal ◽  
Joseph Osborne ◽  
Shuang Zhao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
Data Analysis ◽  
Randomized Clinical Trials ◽  
Individual Patient Data ◽  
Patient Data ◽  
Cancer Outcomes

scholarly journals Mortality in low-risk patients with aortic stenosis undergoing transcatheter or surgical aortic valve replacement: a reconstructed individual patient data meta-analysis

2020 ◽  
Vol 31 (5) ◽  
pp. 587-594
Author(s):  
Mevlüt Çelik ◽  
Milan M Milojevic ◽  
Andras P Durko ◽  
Frans B S Oei ◽  
Ad J J C Bogers ◽  
...  
Keyword(s):  
Data Analysis ◽  
Aortic Stenosis ◽  
Individual Patient Data ◽  
Severe Aortic Stenosis ◽  
Mortality Rates ◽  
Patient Data ◽  
Low Risk ◽  
All Cause Mortality ◽  
Risk Patients

Abstract OBJECTIVES Although the standard of care for patients with severe aortic stenosis at low-surgical risk has included surgical aortic valve replacement (SAVR) since the mid-1960s, many clinical studies have investigated whether transcatheter aortic valve implantation (TAVI) can be a better approach in these patients. As no individual study has been performed to detect the difference in mortality between these 2 treatment strategies, we did a reconstructive individual patient data analysis to study the long-term difference in all-cause mortality. METHODS Randomized clinical trials and propensity score-matched studies that included low-risk adult patients with severe aortic stenosis undergoing either SAVR or TAVI and with reports on the mortality rates during the follow-up period were considered. The primary outcome was all-cause mortality of up to 5 years. RESULTS In the reconstructed individual patient data analysis, there was no statistically significant difference in all-cause mortality between TAVI and SAVR at 5 years of follow-up [30.7% vs 21.4%, hazard ratio (HR) 1.19, 95% confidence interval (CI) 0.96–1.48; P = 0.104]. However, landmark analyses in patients surviving up to 1 year of follow-up showed significantly higher all-cause mortality at 5 years of follow-up (27.5% vs 17.3%, HR 1.77, 95% CI 1.29–2.43; P < 0.001) in patients undergoing TAVI compared to patients undergoing SAVR, respectively. CONCLUSIONS This reconstructed individual patient data analysis in low-risk patients with severe aortic stenosis demonstrates that the 5-year all-cause mortality rates are higher after TAVI than after SAVR, driven by markedly higher mortality rates between 1 and 5 years of follow-up in the TAVI group. The present results call for caution in expanding the TAVI procedure as the treatment of choice for the majority of all low-risk patients until long-term data from contemporary randomized clinical trials are available.

scholarly journals Topiramate in the Treatment of Generalized Convulsive Status Epilepticus in Adults: A Systematic Review with Individual Patient Data Analysis

Drugs ◽  
2016 ◽  
Vol 77 (1) ◽  
pp. 67-74 ◽  
Author(s):  
Francesco Brigo ◽  
Nicola Luigi Bragazzi ◽  
Stanley C. Igwe ◽  
Raffaele Nardone ◽  
Eugen Trinka
Keyword(s):  
Systematic Review ◽  
Data Analysis ◽  
Status Epilepticus ◽  
Individual Patient Data ◽  
Patient Data ◽  
Convulsive Status Epilepticus
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