First in man study of a new semi‐open cell design Zephyr cobalt–chromium stent in large vessels and conduits

2020 ◽  
Vol 96 (2) ◽  
pp. 367-375
Author(s):  
Kothandam Sivakumar ◽  
Avinash Anantharaj ◽  
Palaparti Raghuram ◽  
Raman Krishna Kumar ◽  
Preeti Vani ◽  
...  
Keyword(s):  
Cell Design ◽  
Cobalt Chromium ◽  
Open Cell ◽  
Cobalt Chromium Stent ◽  
Large Vessels

Low-profile visualized intraluminal support Blue stenting within a Neuroform Atlas stent for a large wide-necked aneurysm: A case report and a bench-top experiment

2021 ◽  
pp. 197140092110269
Author(s):  
Tomoko Hayashi ◽  
Hiroyuki Ikeda ◽  
Ryota Ishibashi ◽  
Toshio Fujiwara ◽  
Ryosuke Kaneko ◽  
...  
Keyword(s):  
Case Report ◽  
Coil Embolization ◽  
Cell Design ◽  
Open Cell ◽  
Aneurysm Neck ◽  
Low Profile ◽  
Closed Cell ◽  
High Metal ◽  
Silicon Tube ◽  
Aneurysm Occlusion

Low-profile visualized intraluminal support deployment in an Enterprise has been reported; however, that in an Atlas has yet to be in detail. Enterprise has a closed-cell design, while Atlas has an open-cell design. We detail here a case of a large wide-necked aneurysm treated by coil embolization with low-profile visualized intraluminal support Blue deployment within a Neuroform Atlas and a bench-top experiment using a silicon tube to test low-profile visualized intraluminal support, Atlas, Enterprise, and their combinations. A better low-profile visualized intraluminal support expansion was achieved by simultaneously pushing the wire and the system within the Atlas placed at the aneurysm neck, which resulted in an increased metal coverage of the aneurysm neck and a shorter transition zone with low metal coverage at both ends of the aneurysm neck. This technique may enable a high metal coverage by low-profile visualized intraluminal support expansion without restriction by the Atlas and contribute to aneurysm occlusion by increasing the flow-diverting effect.

scholarly journals Testing bioresorbable stent feasibility in a rat aneurysm model

2019 ◽  
Vol 11 (10) ◽  
pp. 1050-1054 ◽  
Author(s):  
Basil Erwin Grüter ◽  
Dominik Täschler ◽  
Fabio Strange ◽  
Jeannine Rey ◽  
Michael von Gunten ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Treatment Options ◽  
Cerebral Aneurysms ◽  
Parent Artery ◽  
Cobalt Chromium ◽  
Inflammatory Reactions ◽  
Male Wistar Rats ◽  
Bioresorbable Stent ◽  
Cobalt Chromium Stent ◽  
Aneurysm Model

BackgroundAdvances in stent-assisted coiling have incrementally expanded endovascular treatment options for complex cerebral aneurysms. After successful coil consolidation and aneurysm occlusion, endovascular scaffolds are no longer needed. Thus, bioresorbable stents that disappear after aneurysm healing could avoid future risks of in-stent thrombosis and the need for lifelong antiplatelet therapy.ObjectiveTo assess the applicability and compatibility of a bioresorbable magnesium- alloy stent (brMAS) for assisted coiling.MethodsSaccular sidewall aneurysms were created in 84 male Wistar rats and treated with brMAS alone, brMAS + aspirin, or brMAS + coils + aspirin. Control groups included no treatment (natural course), solely aspirin treatment, or conventional cobalt–chromium stent + coils + aspirin treatment. After 1 and 4 weeks, aneurysm specimens were harvested and macroscopically, histologically, and molecularly examined for healing, parent artery perfusion status, and inflammatory reactions. Stent degradation was monitored for up to 6 months with micro-computed and optical coherence tomography.ResultsAneurysms treated with brMAS showed advanced healing, neointima formation, and subsequent stent degradation. Additional administration of aspirin sustained aneurysm healing while reducing stent-induced intraluminal and periadventitial inflammatory responses. No negative interaction was detected between platinum coils and brMAS. Progressive brMAS degradation was confirmed.ConclusionsbrMAS induced appropriate healing in this sidewall aneurysm model. The concept of using bioresorbable materials to promote complete aneurysm healing and subsequent stent degradation seems promising. These results should encourage further device refinements and clinical evaluation of this treatment strategy for cerebrovascular aneurysms.

Randomized comparative trial of a thin-strut bare metal cobalt-chromium stent versus a sirolimus-eluting stent for coronary revascularization

2007 ◽  
Vol 69 (6) ◽  
pp. 790-798 ◽  
Author(s):  
Paolo Ortolani ◽  
Antonio Marzocchi ◽  
Cinzia Marrozzini ◽  
Tullio Palmerini ◽  
Francesco Saia ◽  
...  
Keyword(s):  
Coronary Revascularization ◽  
Comparative Trial ◽  
Bare Metal ◽  
Cobalt Chromium ◽  
Cobalt Chromium Stent ◽  
Sirolimus Eluting Stent

Treatment of intracranial atherosclerotic arterial stenoses with a balloon-expandable cobalt chromium stent (Coroflex Blue): procedural safety, efficacy, and midterm patency

2009 ◽  
Vol 52 (7) ◽  
pp. 645-651 ◽  
Author(s):  
Zsolt Vajda ◽  
Elina Miloslavski ◽  
Thomas Güthe ◽  
Elisabeth Schmid ◽  
Christoph Schul ◽  
...  
Keyword(s):  
Cobalt Chromium ◽  
Cobalt Chromium Stent ◽  
Arterial Stenoses

Neointimal hyperplasia in a thin-strut cobalt–chromium stent: Insights from detailed 3-D intravascular ultrasound analysis

2010 ◽  
Vol 145 (1) ◽  
pp. 125-126 ◽  
Author(s):  
Hiromasa Otake ◽  
Junya Ako ◽  
Katsuhisa Waseda ◽  
Ryota Sakurai ◽  
Atsushi Hirohata ◽  
...  
Keyword(s):  
Intravascular Ultrasound ◽  
Neointimal Hyperplasia ◽  
Cobalt Chromium ◽  
Cobalt Chromium Stent

scholarly journals Bilateral Migration of Open-Cell Design Carotid Stents in the Early Post-Procedure Period: A Rare Complication

2014 ◽  
Vol 20 (6) ◽  
pp. 761-765
Author(s):  
Amar Swarnkar ◽  
Shri Harsha Krishna ◽  
Nicole Zimmerman ◽  
Julius Latorre ◽  
Eric M Deshaies
Keyword(s):  
Rare Complication ◽  
Duplex Ultrasound ◽  
Stent Migration ◽  
Cell Design ◽  
Open Cell ◽  
Post Procedure ◽  
Proximal Migration ◽  
Bilateral Carotid ◽  
The Right ◽  
Bilateral Carotid Artery

We describe migration of bilateral carotid stents in a 63-year-old man shortly after stenting. Carotid stent migration was found four days post-procedure on the right side and one day post-procedure on the left side on angiography and duplex ultrasound, respectively. This is the first reported case of bilateral carotid artery stenting complicated by bilateral proximal migration of open-cell design stents in the early post-procedure period.

scholarly journals Time Course of Reendothelialization of Stents in a Normal Coronary Swine Model

2011 ◽  
Vol 48 (6) ◽  
pp. 1109-1117 ◽  
Author(s):  
A. Pérez de Prado ◽  
C. Pérez-Martínez ◽  
C. Cuellas-Ramón ◽  
J. Manuel Gonzalo-Orden ◽  
M. Regueiro-Purriños ◽  
...  
Keyword(s):  
Time Course ◽  
Cell Types ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Giant Cells ◽  
Swine Model ◽  
Cobalt Chromium ◽  
Drug Eluting ◽  
Late Thrombosis ◽  
Cobalt Chromium Stent ◽  
Transluminal Coronary Angioplasty

Late thrombosis of coronary drug-eluting stents is an infrequent but serious complication of percutaneous transluminal coronary angioplasty. The best predictor of this event is the lack of endothelialization of stent struts. The objective of this study is to characterize and quantify the time course of endothelialization of different stents implanted in nonatherosclerotic swine coronary arteries. Thirty-three Carbofilm-coated stents were implanted percutaneously in 11 anesthetized domestic, crossbred pigs (weight 25 ± 3 kg, 2 months old). Each animal received 1 stainless steel stent (SS), 1 cobalt-chromium stent (CCS), and 1 tacrolimus-eluting stent (TES) in each coronary artery. Follow-up periods were 1 day (n = 9 stents), 3 days (n = 9 stents), and 7 days (n = 15 stents). Longitudinal sections of the stented vessels were examined using scanning electron microscopy. At 1 day, there was scarce, patchy endothelialization with areas of fibrin; the endothelialization rate was similar for all the stents (SS, 29% ± 23%; CCS, 29% ± 24%; TES, 31% ± 25%; P = .9). At 3 days, there were more endothelial cells but with immature features and giant cells over fibrin; the endothelialization was greater in SS and CCS than in TES (SS, 79% ± 14%; CCS, 81% ± 17%; TES, 46% ± 9%; P = .007). At 7 days, arteries showed better endothelialization with few giant cells; the endothelialization was greater in SS and CCS than in TES (SS, 95% ± 4%; CCS, 98% ± 4%; TES, 79% ± 9%; P = .01). In conclusion, the described model is useful for the analysis of endothelialization of coronary stents and facilitates measurement of its rate of formation and characterization of the involved cell types.

scholarly journals Coil Migration through a Neuroform 3 Stent during Endovascular Coiling

2009 ◽  
Vol 15 (2) ◽  
pp. 219-222 ◽  
Author(s):  
A. O'Hare ◽  
J. Thornton ◽  
P. Brennan
Keyword(s):  
Endovascular Coiling ◽  
Cell Design ◽  
Open Cell ◽  
Carotid Siphon ◽  
Coil Migration

A 43-year-old woman attended for stent assisted coiling. A Neuroform 30 × 4.5 mm stent had been successfully placed over the left periophthalmic aneurysm. During the coiling the first coil migrated through the crowns in the stent, lodging at the MCA bifurcation. We believe that the coil herniated through the overlying stent due to the carotid siphon curvature and the open cell design. Furthermore the distal markers of the stent impeded coil extraction with a MERCI device.

Sign in / Sign up

Export Citation Format

Share Document