scholarly journals Two decades after coronary radiation therapy: A single center longitudinal clinical study

2019 ◽  
Vol 96 (3) ◽  
Author(s):  
Sumant P. Radhoe ◽  
Anne‐Sophie Schuurman ◽  
Jurgen M. Ligthart ◽  
Karen Witberg ◽  
Peter P. T. Jaegere ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clinical Study ◽  
Single Center ◽  
Longitudinal Clinical Study

Combining radiation therapy with anti-PD-1 for patients with advanced hepatocellular carcinoma: An open-label, single-center, single-arm clinical study.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16117-e16117
Author(s):  
Jian-Xu Li ◽  
Ting-Shi Su ◽  
Xiao-Feng Lin ◽  
Yi-Tian Chen ◽  
Shi-Xiong Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Trial ◽  
Radiation Therapy ◽  
Clinical Study ◽  
Cancer Staging ◽  
Advanced Hepatocellular Carcinoma ◽  
Single Center ◽  
Open Label ◽  
Grade 3 ◽  
Clinical Trial Information

e16117 Combining radiation therapy with anti-PD-1 for patients with advanced hepatocellular carcinoma: an open-label, single-center, single-arm clinical study Jian-Xu Li, Ting-Shi Su, Xiao-Feng Lin, Yi-Tian Chen, Shi-Xiong Liang, Bang-De Xiang; Guangxi Medical University Cancer Hospital, Nanning, China Abstract Research Funding: Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China. Guangxi Medical and Health Appropriate Technology Development and Application Project (No. S2019039), Guangxi, China. Background: Based on the results of recent studies, the PD-1 monoclonal antibodies have been approved to treat the patients with advanced hepatocellular carcinoma (HCC) by the FDA. Radiation therapy (RT) can enhance responsiveness to PD-1 monoclonal antibody by potential mechanisms. A phase Ⅱa study was conducted to assess the safety and the efficacy of combining RT with anti-PD-1 for patients with advanced hepatocellular carcinoma. Methods: Patients with advanced HCC were eligible. Stereotactic body radiation therapy (SBRT) were adopted, and the dose of radiation were Dt-PGTV 30-50 Gy/10fractions. Camrelizumab (200mg) were given intravenously every 3 weeks since the first day of RT until disease progression, or intolerable toxicity. Adverse events (AEs) and objective response rate (ORR) were summarized to assess the safety and efficacy. Results: From April 2020 to November 2020, 17 patients were enrolled (median age 54, range 32-69). 15 (88%) patients were male. 14 (82%) had ECOG performance score of 0. All the patients had Child-Pugh score A. 16 patients staged as Barcelona Clinic Liver Cancer staging C or China Liver Cancer staging Ⅲ. Extrahepatic metastases were identified in 11 (65%) patients. 13 (77%) patients were Hepatitis B virus infected. 15 (88%) patients had previously 2 lines or more chemotherapy. 9 (53%) patients had Alpha-fetoprotein level≥400 ng/ml. The ORR was 47%. The best response assessed by RECIST 1.1 was partial response (8 patients). Four patients had grade 3 immune-related adverse events (irAEs), including increased aspartate aminotransferase and alanine transaminase (n =1)，decreased hemoglobin (n =1)，decreased platelet count (n =1)，decreased neutrophil count (n =1). All grade 3 irAEs were mitigated with proper treatment. None treatment-related deaths occurred. Conclusions: In this study, RT combined with anti-PD-1 had an acceptable safety profile and indicated an effective treatment option in patients with unresectable HCC. Clinical trial information: NCT04193696. Clinical trial information: NCT04193696.

scholarly journals The neurological presentations associated with COVID-19: A retrospective single-center clinical study in the Republic of Dagestan, Russia

2021 ◽  
Vol 429 ◽  
pp. 119812
Author(s):  
Zukhra Gadzhieva ◽  
Zaira Khamidova ◽  
Teyli Magomedova ◽  
Zaira Kaplanova
Keyword(s):  
Clinical Study ◽  
Single Center ◽  
The Republic

scholarly journals iShim and Water Excitation Improves the Signal-to-Noise Ratio on q-Space Imaging: A Single-Center Clinical Study

2018 ◽  
Vol 08 (04) ◽  
pp. 244-259
Author(s):  
Yoshifumi Sone ◽  
Junichi Hata ◽  
Yasushi Sera ◽  
Katsuya Maruyama ◽  
Thomas Benkert ◽  
...  
Keyword(s):  
Clinical Study ◽  
Signal To Noise Ratio ◽  
Single Center ◽  
Signal To Noise ◽  
Water Excitation ◽  
Noise Ratio

scholarly journals A single-center clinical study of hepatic artery variations in laparoscopic pancreaticoduodenectomy

Medicine ◽  
2020 ◽  
Vol 99 (21) ◽  
pp. e20403
Author(s):  
Wei Zhang ◽  
Kun Wang ◽  
Songyang Liu ◽  
Yingchao Wang ◽  
Kai Liu ◽  
...  
Keyword(s):  
Clinical Study ◽  
Hepatic Artery ◽  
Laparoscopic Pancreaticoduodenectomy ◽  
Single Center
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