Rationale and design of a global registry to evaluate real-world clinical outcomes in patients with atrial fibrillation and high risk of stroke treated with left atrial appendage occlusion using the AMPLATZER amulet device-Perspective of available/ongoing

2017 ◽  
Vol 91 (3) ◽  
pp. 540-547 ◽  
Author(s):  
David Hildick-Smith ◽  
Hans-Christoph Diener ◽  
Boris Schmidt ◽  
Vincent Paul ◽  
Magnus Settergren ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Clinical Outcomes ◽  
Real World ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Left Atrial Appendage Occlusion ◽  
Global Registry

scholarly journals Short-Term Apixaban for Documented Left Atrial Appendage Thrombus in High-Risk Atrial Fibrillation Patients Undergoing Left Atrial Appendage Occlusion

TH Open ◽  
2020 ◽  
Vol 04 (04) ◽  
pp. e351-e353
Author(s):  
Wern Yew Ding ◽  
Gregory Y.H. Lip ◽  
Timothy Fairbairn ◽  
Sukumaran Binukrishnan ◽  
Afshin Khalatbari ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Short Term ◽  
Left Atrial Appendage Thrombus ◽  
Left Atrial Appendage Occlusion

284Outcomes after left atrial appendage occlusion with AMPLATZER Amulet and WATCHMAN device: Results from the ORIGINAL registry (saxOnian RegIstry analyzinG and followINg left atrial Appendage cLosure)

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
L Kretzler ◽  
C Wunderlich ◽  
M Christoph ◽  
A Langbein ◽  
S G Spitzer ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Oral Anticoagulation ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Minor Bleeding ◽  
Left Atrial Appendage Closure ◽  
Left Atrial Appendage Occlusion

Abstract Aims Left atrial appendage occlusion (LAAO) is a therapeutic option for patients with non-valvular atrial fibrillation (NVAF) and high risk of bleeding. This study reports outcomes of patients enrolled in the prospective multicentre, investigator initiated real life registry in the Free State of Saxony (saxOnian RegIstry analyzinG and followINg left atrial Appendage cLosure). Methods and results Data of all consecutive 521 patients (64.7% adult males, 35.3% adult females, mean age: 75.1 (SD 7.9) years with non-valvular atrial fibrillation undergoing interventional left atrial appendage occlusion procedure in the ORIGINAL prospective registry were analysed. The CHA2DS2-VASc and HAS-BLED scores were 4.3 (SD 1.5) and 3.7 (SD 1.1), respectively. 78.9% of the patients had a history of bleeding. 89.3% of the patients were considered as non-eligible for long term oral anticoagulation. A left atrial appendage occlusion device was successfully implanted in 97.5% of cases. A mean follow-up of 463 days could be reached in 386 patients. Among these, the distribution of the follow-up length reached was as follows: 1 year 205, 2 years 118, 3 years 65 and 4 years 17 patients. In the follow-up the annual frequency of stroke was very low (0.4%), which resulted in the 4.98% absolute risk reduction in the amount of thromboembolic strokes, which would have been expected according to the calculated CHA2DS2-VASc score in the hypothetic group not receiving any anticoagulant therapy. The occurrence of major and minor bleeding in the follow-up was 1.55% and 3.37% respectively. Conclusions In this prospective multicentre study we included the patients who are at high risk of stroke and bleeding. The annual ischemic stroke rate was 0.4%, the LAA could be sealed in 97.5%. Six months after the LAA closure only 3.63% of all patients were further on treated using oral anticoagulation. Considering the stroke reduction rates, the implantation of an LAAO device proves to be effective and safe in the clinical routine in the studied population. Acknowledgement/Funding None

scholarly journals Long-standing Persistent Atrial Fibrillation Ablation in a Patient With High Risk of Bleeding

2020 ◽  
Vol 33 (2) ◽  
pp. 115-121
Author(s):  
Cristiano Pisani ◽  
Muhieddine Chokr ◽  
Carina Hardy ◽  
Sissy Lara ◽  
Mauricio Scanavacca
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Persistent Atrial Fibrillation ◽  
Posterior Wall ◽  
Atrial Appendage ◽  
Risk Of Bleeding ◽  
Left Atrial Appendage Occlusion ◽  
Left Atrial Appendage Isolation

A 57 year-old patient with dilated cardiomyopathy, long-standing persistent atrial fibrillation, heart failure and episodes of gastrointestinal bleeding underwent AF ablation with pulmonary vein isolation, homogeneization of septal scar, posterior wall isolation and also left atrial appendage isolation. Additionally, because of the high risk of embolism, underwent left atrial appendage occlusion.

Left atrial appendage occlusion in high-risk patients with non-valvular atrial fibrillation

Heart ◽  
2016 ◽  
Vol 102 (24) ◽  
pp. 1969-1973 ◽  
Author(s):  
Sergio Berti ◽  
Luigi Emilio Pastormerlo ◽  
Marco Rezzaghi ◽  
Giuseppe Trianni ◽  
Umberto Paradossi ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
High Risk ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
High Risk Patients ◽  
Left Atrial Appendage Occlusion ◽  
Risk Patients
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