Cerebral white matter lesion burden is associated with the degree of aortic valve calcification and predicts peri-procedural cerebrovascular events in patients undergoing transcatheter aortic valve implantation (TAVI)

2017 ◽  
Vol 91 (4) ◽  
pp. 774-782 ◽  
Author(s):  
Jonas Doerner ◽  
Patrick A. Kupczyk ◽  
Marius Wilsing ◽  
Julian A. Luetkens ◽  
Klaus Storm ◽  
...  
Keyword(s):  
White Matter ◽  
Aortic Valve ◽  
White Matter Lesion ◽  
Cerebral White Matter ◽  
Aortic Valve Calcification ◽  
Transcatheter Aortic Valve ◽  
Cerebrovascular Events ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
Cerebral White Matter Lesion

Abstract 12786: Antithrombotic Therapy After Transcatheter Aortic Valve Implantation in Patients With Concomitant Indications for Long-term Oral Anticoagulation: A Systemic Review and Meta-analysis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Gonçalo Costa ◽  
Lino Gonçalves ◽  
rogerio teixeira
Keyword(s):  
Aortic Valve ◽  
Oral Anticoagulation ◽  
Meta Analysis ◽  
Antithrombotic Treatment ◽  
Transcatheter Aortic Valve ◽  
Cerebrovascular Events ◽  
All Cause Mortality ◽  
Aortic Valve Implantation ◽  
Valve Implantation

Background: Ischemic and bleeding complications after transcatheter aortic valve implantation (TAVI) remain prevalent and affect survival. Atrial fibrillation (AF) is common in patients undergoing TAVI and constitutes an indication for long-term oral anticoagulation (OAC). Current guidelines on antithrombotic treatment in patients who have an indication for OAC after TAVI are based on expert opinion and suggest the use of vitamin K antagonist (VKA) either alone or in combination with aspirin or clopidogrel. Purpose: To compare OAC (VKA or direct oral anticoagulant) versus OAC in combination with single antiplatelet therapy (SAPT), either aspirin or clopidogrel, as antithrombotic treatment following TAVI in patients with an indication for long-term OAC or the prevention of cerebrovascular events, bleeding events and all-cause mortality. Methods: We systematically searched PubMed, Embase and Cochrane databases, in April 2020, for both interventional or observational studies comparing OAC with OAC plus SAPT. Random-effects meta-analysis for OAC and OAC combined with SAPT were performed. Results: Four studies were included (three registry-based and one randomized clinical trial) providing a total of 1218 patients, and 69 pooled cerebrovascular events. There was no statistical difference between OAC and OAC plus SAPT for the prevention of cerebrovascular events after TAVI (pooled OR 0.89 [0.51, 1.55], P=0.69, I 2 = 0%) - Figure. Similarly, there was a similar rate of all-cause mortality (pooled OR 0.98 [0.72, 1.35], P=0.91, I 2 = 0%). Furthermore, the rate of major bleeding or life-threatening events was significantly lower for OAC compared with the combined therapy (pooled OR 0.45 [0.29, 0.70], P<0.01, I 2 = 5%). Conclusions: Our pooled data suggests that for patients with indication for long-term oral anticoagulation after TAVI, the routine use of double anti-thrombotic therapy (SAPT+OAC) compared to the use of OAC, conferred an increased risk of bleeding

scholarly journals Aortic valve calcification volumes and chronic brain infarctions in patients undergoing transcatheter aortic valve implantation

2019 ◽  
Vol 35 (11) ◽  
pp. 2123-2133 ◽  
Author(s):  
Wieneke Vlastra ◽  
Thomas P. W. van den Boogert ◽  
Thomas Krommenhoek ◽  
Anne-Sophie G. T. Bronzwaer ◽  
Henk J. M. M. Mutsaerts ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Aortic Valve Calcification ◽  
Valve Calcification ◽  
Transcatheter Aortic Valve ◽  
Aortic Valve Implantation ◽  
Valve Implantation
Sign in / Sign up

Export Citation Format

Share Document