First in vivo evaluation of a flexible self-apposing left atrial appendage closure device in the canine model

2015 ◽  
Vol 86 (1) ◽  
pp. 173-181 ◽  
Author(s):  
Yanping Cheng ◽  
Gerard Conditt ◽  
Genghua Yi ◽  
Armando Tellez ◽  
Michael Corcoran ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Canine Model ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure ◽  
In Vivo Evaluation

scholarly journals TCT-765 First In-Vivo Evaluation of the Ultrasept Left Atrial Appendage Closure Device

2012 ◽  
Vol 60 (17) ◽  
pp. B223 ◽  
Author(s):  
Yanping Cheng ◽  
Gerard Conditt ◽  
Genghua Yi ◽  
Alyssa Wagner ◽  
Patricia Mount ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure ◽  
In Vivo Evaluation

scholarly journals Preclinical Assessment of a Novel Conformable Foam-Based Left Atrial Appendage Closure Device

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Robert J. Sommer ◽  
Ronald Lamport ◽  
David Melanson ◽  
Carol Devellian ◽  
Andy Levine ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Canine Model ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure ◽  
Novel Device ◽  
In Vitro Assessment

Background. Left atrial appendage (LAA) occlusion has been established as an alternative to systemic anticoagulation for stroke prevention in patients with atrial fibrillation; however, limitations of current devices have slowed adoption. We present preclinical evaluations of a novel device, the Conformal Left Atrial Appendage Seal (CLAAS). Methods. An in vitro assessment of conformability was conducted to evaluate the two CLAAS devices (regular 27 mm and large 35 mm) and a Watchman 2.5 (27 mm). Devices were placed within silicone tubes and compressed in a vise submerged in a water bath at 37°C. Changes in device diameter and visual seal were noted. Acute ( n = 1 ) and chronic 60-day ( n = 6 ) canine studies with gross and histologic assessment were performed. Results. Conformability bench tests demonstrated that the regular CLAAS implant was able to seal oval orifices from 20 × 30   mm to 15 × 33   mm and the large from 30 × 35   mm to 20 × 40   mm . As the CLAAS implant was compressed in the minor diameter, it increased in the major diameter, thereby filling the oval space, whereas the Watchman 2.5 showed gaps and maintained its round configuration when compressed in one direction. Seven devices were successfully implanted in the canine model with complete seal without thrombus. Histologic examination showed complete neointima covering with minimal inflammation at 60 days. Conclusions. Preclinical testing demonstrated the conformability of the CLAAS implant and its ability to seal the LAA. Clinical studies are ongoing to characterize the utility of the CLAAS implant in the treatment of patients with atrial fibrillation.

Preclinical assessment of a modified Occlutech left atrial appendage closure device in a canine model

2016 ◽  
Vol 221 ◽  
pp. 413-418 ◽  
Author(s):  
Jung-Sun Kim ◽  
Seul-Gee Lee ◽  
Sung-Kyung Bong ◽  
Se-Il Park ◽  
Sung-Yu Hong ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Canine Model ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure

scholarly journals B-PO03-012 LEFT ATRIAL APPENDAGE CLOSURE DEVICE ASSOCIATED WITH LARGE THROMBUS

Heart Rhythm ◽  
2021 ◽  
Vol 18 (8) ◽  
pp. S193-S194
Author(s):  
Kristin Babb ◽  
Emrie D. Tomaiko ◽  
Carla Lockhart ◽  
J. Peter Weiss ◽  
H. Kenith Fang ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure

scholarly journals Percutaneous Retrieval of a Left Atrial Appendage Closure Device

2021 ◽  
Author(s):  
Achille Gaspardone ◽  
Maria Benedetta Giannico ◽  
Roberto Cancellieri ◽  
Laura Velardi ◽  
Antonio Giuseppe Posteraro ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure ◽  
Percutaneous Retrieval

Autopsy Findings of Left Atrial Appendage Closure Device

2021 ◽  
pp. 107384
Author(s):  
Masaaki Nakase ◽  
Masahiko Asami ◽  
Kazuyuki Yahagi ◽  
Yu Sato ◽  
Atsuhito Nakayama ◽  
...  
Keyword(s):  
Left Atrial ◽  
Left Atrial Appendage ◽  
Atrial Appendage ◽  
Closure Device ◽  
Left Atrial Appendage Closure ◽  
Autopsy Findings
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