Chronically anticoagulated patients who need surgery: Can low-molecular-weight heparins really be used to “bridge” patients instead of intravenous unfractionated heparin?

2009 ◽  
Vol 74 (S1) ◽  
pp. S17-S21 ◽  
Author(s):  
Michael R. Jaff
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Low Molecular Weight ◽  
Low Molecular Weight Heparins ◽  
Anticoagulated Patients

Osteoblast Growth Inhibition by Unfractionated Heparin and by Low Molecular Weight Heparins: An in-vitro Investigation

2002 ◽  
Vol 8 (3) ◽  
pp. 251-255 ◽  
Author(s):  
H. J. Kock ◽  
A. E. Handschin
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Cell Cultures ◽  
Term Therapy ◽  
Low Molecular Weight ◽  
High Dose ◽  
Low Molecular Weight Heparins ◽  
In Vitro Investigation

Osteoporosis is a rare but potentially severe complication under high-dose, long-term unfractionated heparin therapy. Low-molecular-weight heparins (LMWHs) have gained increased importance in antithrombotic therapy over the past decade. Whether this heterogeneous group of drugs carries a comparable risk of osteoporosis in long-term application is unknown. In a standardized in vitro model, the effects of 4 different low-molecular-weight heparins (nadroparin, enoxaparin, dalteparin, certoparin) on osteoblast growth were studied at the same dose (50,μg/mL). As control, the effect of unfractionated heparin (Liquemin) was tested on human osteoblasts in vitro at an equal dose. Human osteoblast cell cultures were incubated with equal doses of the heparins, and cell concentrations were measured after 48 and 96 hours. In addition, a fluorescence assay was performed to detect potential cytotoxic effect of heparins on bone cells. In comparison to control groups of non-incubated cell cultures, LMWHs caused a significant inhibition of osteoblast growth (p<0.05). Therefore, the risk of osteoporosis under long-term therapy with high doses of LMWHs cannot be excluded and should be further evaluated in clinical trials.

Pharmacokinetic Studies of Standard Unfractionated Heparin, and Low Molecular Weight Heparins in the Rabbit

1988 ◽  
Vol 14 (01) ◽  
pp. 18-27 ◽  
Author(s):  
Bernard Boneu ◽  
Claudine Caranobe ◽  
Yves Cadroy ◽  
Frederique Dol ◽  
Anne-Marie Gabaig ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Unfractionated Heparin ◽  
Low Molecular Weight ◽  
Pharmacokinetic Studies ◽  
Low Molecular Weight Heparins
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