Systemic vein stents-A solution to a growing Challenge

2009 ◽  
Vol 73 (2) ◽  
pp. 189-189
Author(s):  
Charles E. Mullins
Keyword(s):  
Systemic Vein

Cardiovascular responses to insulin in the absence of hypoglycemia

1962 ◽  
Vol 202 (2) ◽  
pp. 249-252 ◽  
Author(s):  
Santiago A. Pereda ◽  
John W. Eckstein ◽  
François M. Abboud
Keyword(s):  
Pressor Response ◽  
Direct Action ◽  
Cardiovascular Responses ◽  
Blocking Agent ◽  
Neuromuscular Blocking ◽  
Right Atrial ◽  
Systemic Vein ◽  
Anesthetized Dogs ◽  
Adrenergic Blocking ◽  
The Brain

Cardiovascular responses to intravenous administration of insulin were studied in lightly anesthetized dogs treated with a neuromuscular blocking agent. An early transient pressor response was observed. This abrupt increase in arterial pressure appeared 2–9 min after insulin was given. It was accompanied by increases in cardiac output and right atrial pressure. It occurred in the presence of hyperglycemia and in the absence of hypoglycemia. It was not altered by glucagon but it could be antagonized by ganglionic and adrenergic blocking drugs and by pentobarbital. The response could be produced when insulin was given in the carotid artery in doses that caused no effect when injected in a systemic vein. The experiments suggest that insulin may have a direct action on the brain.

Abnormalities of Pulmonary Venous Return

Chest Imaging ◽  
2019 ◽  
pp. 533-537
Author(s):  
Kristopher W. Cummings
Keyword(s):  
Atrial Septal Defect ◽  
Septal Defect ◽  
Venous Return ◽  
Pulmonary Veins ◽  
Lower Lobe ◽  
Scimitar Syndrome ◽  
Systemic Vein ◽  
Anomalous Pulmonary Venous Return ◽  
The Right

Abnormalities of pulmonary venous return in adults result from anomalous drainage of one or more pulmonary veins into a systemic vein, resulting in a left-to-right shunt. Partial anomalous pulmonary venous return (PAPVR) is most commonly encountered in adults in the upper lobes. PAPVR in the right upper lobe is commonly associated with a sinus venous atrial septal defect, whereas in the right lower lobe it is commonly encountered in association with other anomalies in Scimitar syndrome. Left upper lobe PAPVR is usually isolated. In some instances, patients can develop pulmonary over-circulation and hypertension, necessitating intervention. This chapter emphasizes CT and MR features key to recognizing and diagnosing these anomalies.

Distribution of pulmonary vascular resistance during lactic acid infusion in dogs

1990 ◽  
Vol 68 (4) ◽  
pp. 1328-1336 ◽  
Author(s):  
K. W. Presberg ◽  
J. I. Sznajder ◽  
J. Melendres ◽  
T. Lewis ◽  
C. Abrahams ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acidosis ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Light And Electron Microscopy ◽  
Balloon Occlusion ◽  
Longitudinal Distribution ◽  
Acid Infusion ◽  
Systemic Artery ◽  
Systemic Vein

We sought to determine the longitudinal distribution of pulmonary vascular resistance (PVR) in acute lactic acidosis utilizing pulmonary artery and vein balloon occlusion techniques (Holloway et al. J. Appl. Physiol. 54: 840-851, 1983). In anesthetized dogs, both a systemic vein (I-V) infusion and systemic artery (I-A) infusion of L-lactic acid were studied to control for potential effects of factors other than pH on PVR. During progressive I-A infusion (n = 9) to a pH of 6.94 +/- 0.06 there was no significant change in PVR or its distribution. In contrast, I-V infusion (n = 9) to a pH of 7.08 +/- 0.09 increased median PVR from 3.6 to 21.7 mmHg.1(-1).min (P less than 0.001), due to an increase in middle segment resistance (0.0-15.4 mmHg.1(-1).min, P less than 0.02). Examination by light and electron microscopy demonstrated pulmonary capillary obstruction with hemolyzed erythrocyte (RBC) membranes with I-V infusion, but representative I-A animals did not demonstrate these findings. Conceivably, the systemic vascular bed filtered the fragmented RBC membranes in the I-A model, but this microvascular obstruction with altered RBCs and RBC fragments caused the pulmonary hypertension observed in the I-V infusion. We conclude that lactic acidosis does not increase pulmonary vascular tone in dogs, a finding compatible with most previous studies in which observed increases in PVR may be attributed to other effects from I-V acid infusion on circulating blood elements.

scholarly journals Prevalence of arrhythmias on the long term of adult patients with partial anomalous pulmonary venous connection treated surgically and conservatively: data from the SACHER registry and a French center

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Touray ◽  
J Bouchardy ◽  
M Ladouceur ◽  
M Schwerzmann ◽  
M Greutmann ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Late Complication ◽  
Pulmonary Veins ◽  
Pacemaker Implantation ◽  
Funding Source ◽  
Cardiac Symptoms ◽  
Systemic Vein ◽  
Anomalous Pulmonary Venous Connection

Abstract Introduction Partial anomalous pulmonary venous connection (PAPVC) is a rare congenital heart disease, characterized by one or some but not all pulmonary veins anomalously connected to the right atrium or a systemic vein. PAPVC is either an isolated shunt lesion or associated with an atrial septal defect (ASD). This study compares the arrhythmic outcome of patients treated surgically with those clinically monitored. Method Clinical, surgical, imaging and invasive data of PAPVC patients were retrospectively reviewed from 7 centers from the Swiss Adult Congenital HEart disease Registry (SACHER) and one French center. Results A total of 168 patients with PAPVC were identified. Most (77%) patients underwent surgery, while the remaining (23%) ones were treated conservatively with clinical monitoring. The operated group (OG) had a significantly higher number of associated ASD (N=106, 82%) (p<0.001) and a higher number of anomalous pulmonary veins leading to a mean Qp:Qs at 2.5±1.2 before surgery (table). Moreover, the majority of patients in the OG had cardiac symptoms (N=78, 60%) and were diagnosed at a significantly younger age (table). Mean age at operation was 27±20 years. Age did not differ at latest follow-up (table). Holter recordings revealed a higher prevalence of arrhythmia in the OG (p=0.031), mainly of supraventricular tachyarrhythmias (table). The occurrence of ventricular non-sustained tachycardia and of bradyarrhythmia did not statistically differ between groups. Patients in the OG required more often medical treatment for arrhythmias: 12 (9%) needed electrophysiological study in the OG and none in the NOG (p=0.057). The amount of patients requiring a pacemaker implantation in the OG (11%) was significantly higher than that of NOG (0%) (p=0.039). Conclusion Patients after PAPVC repair present with a significant higher burden of arrhythmia than conservatively treated patients, either due to a larger shunt pre-operatively and/or as a late complication of the corrective surgery itself. Funding Acknowledgement Type of funding source: Private grant(s) and/or Sponsorship. Main funding source(s): Unrestricted grant from Actelion, Switzerland

scholarly journals Natural Infection of Alstroemeria brasiliensis with Lily Mottle Virus

Plant Disease ◽  
2000 ◽  
Vol 84 (1) ◽  
pp. 103-103 ◽  
Author(s):  
I. Bouwen ◽  
R. A. A. van der Vlugt
Keyword(s):  
Polymerase Chain Reaction Amplification ◽  
Natural Infection ◽  
Tobacco Rattle Virus ◽  
Chenopodium Quinoa ◽  
Flower Color ◽  
Systemic Vein ◽  
Leaf Chlorosis ◽  
Local Lesions ◽  
Funded Project ◽  
Reaction Amplification

During a survey for a European Union-funded project on viruses of Alstroemeria, two A. brasiliensis plants were found expressing virus-like symptoms, including leaf chlorosis with deep-green oval spots and flower color breaking. In enzyme-linked immunosorbent assays (ELISA), no positive reaction was obtained with antisera to Alstroemeria mosaic, Alstroemeria carla, Cucumber mosaic, Freesia mosaic, or Tobacco rattle virus or potyvirus-specific monoclonal antibodies (Agdia, Elkhart, IN). ELISA reactions were positive with antisera to Lily mottle (LMoV) and Rembrandt tulip breaking viruses (1). In electron microscopy preparations of A. brasiliensis, potyvirus-like particles were observed. Using sap-inoculation, the virus was transferred to a range of host species. Chenopodium quinoa, Nicotiana occidentalis accession 37B, and N. occidentalis subsp. obliqua (P1) expressed local lesions; N. clevelandii expressed local and systemic mottle; and N. benthamiana expressed local lesions, systemic vein yellowing, and leaf crinkling. Isolated total RNA from infected N. benthamiana was used for initial cDNA synthesis and polymerase chain reaction amplification with a potyvirus-specific primer set (2). The amplicon (≈670 bp) was cloned and sequenced. The sequence showed 92% homology with the corresponding region of LMoV RNA (GenBank accession no. S44147). The results confirm the infection of A. brasiliensis with LMoV. This is the first report of natural infection of Alstroemeria by LMoV. References: (1) E. L. Dekker et al. J. Gen. Virol. 74:881, 1993. (2) R. A. A. van der Vlugt et al. Phytopathology 89:148, 1999.

scholarly journals Characterization of a Novel Resistance-Breaking Isolate of Potato Virus Y in Nicotiana Tabacum

2014 ◽  
Vol 3 (1) ◽  
pp. 01-10
Author(s):  
Jae-Hyun Kim ◽  
Young-Soo Kim ◽  
Soo-Won Jang ◽  
Yong-Ho Jeon
Keyword(s):  
Potato Virus ◽  
Potato Virus Y ◽  
Biological Properties ◽  
Systemic Movement ◽  
Pvy Resistance ◽  
Resistance Breaking ◽  
Systemic Vein ◽  
Vein Necrosis ◽  
Tobacco Cultivar

Potato virus Y (PVY) was identified from a PVY-resistance flue-cured tobacco variety KF120 showing vein necrosis at Buron province, Korea. Biological properties of the isolate named PVY-ToBR1 was characterized using various host plants with another isolate PVY-ToJC37. The isolated PVY-ToBR1 induced systemic vein necrosis symptoms on a PVY-resistant tobacco cultivar (VAM) harboring potyvirus resistant va gene, though tissue printing showed the systemic movement of virus was slightly delayed. By contrast, the isolate PVY-ToJC37 failed to infect VAM plants and the virus was not detected on inoculated leaf and systemic leaves in VAM plants. Similarly, the isolated PVY-ToBR1 induced distinctly systemic vein necrosis symptoms on PVY-resistant tobacco cultivars (V.SCR, PBD6, TN86, TN90, Virgin A Mutant, NC744, and Wislica) that have the recessive potyvirus resistance gene va, but PVY-ToJC37 did not infect systemically infect these tobacco cultivars, suggesting that PVY-ToBR1 is a novel resistance-breaking isolate in tobacco. The coat protein (CP) genes of PVY-ToBR1 and PVY-ToJC37 were amplified using RT-PCR assays with specific primers for PVY isolates and nucleotide sequences of the CP genes were determined. The isolate PVY-ToBR1 showed 88.4% - 99.4% and 86.6% - 99.4% CP identities to the 46 different PVY isolates at the nucleotide and amino acid, respectively. Phylogenetic relationship from CP comparisons showed that PVY-ToBR1 isolate clustered with PVYNTN isolates and PVY-ToBR1 isolate more closely related to the isolates from European than from North American PVY NTN.

Bidirectional coronary venous return in the partial unroofed coronary sinus syndrome complicated by coronary sinus orifice atresia

2020 ◽  
Vol 30 (4) ◽  
pp. 582-584 ◽  
Author(s):  
Dai Asada ◽  
Hisato Ito
Keyword(s):  
Coronary Sinus ◽  
Venous Return ◽  
Paradoxical Embolism ◽  
Pressure Balance ◽  
Caval Vein ◽  
Unroofed Coronary Sinus ◽  
Superior Caval Vein ◽  
Systemic Vein ◽  
Coronary Sinus Orifice Atresia ◽  
Unroofed Coronary Sinus Syndrome

AbstractUnroofed coronary sinus syndrome complicated by coronary sinus orifice atresia is a rare congenital anomaly. There are two alternate exits for coronary venous return: unroofed coronary sinus and persistent left superior caval vein. The coronary venous direction could be bidirectional depending on the pressure balance between the left atrium and the systemic vein. This anomaly has the risk of heart failure, paradoxical embolism, and cyanosis.

Venous and arterial responses to norepinephrine in dogs treated with reserpine

1964 ◽  
Vol 206 (2) ◽  
pp. 299-303 ◽  
Author(s):  
Francois M. Abboud ◽  
John W. Eckstein
Keyword(s):  
Small Vessel ◽  
Small Vessels ◽  
Arterial Resistance ◽  
Systemic Vein ◽  
Vasoconstrictor Effect ◽  
Vascular Responsiveness ◽  
Infusion Of Norepinephrine ◽  
Arterial Responses

Experiments were done to see if the effects of norepinephrine upon veins, arteries, and small vessels are augmented in dogs after treatment with reserpine. With intra-arterial injection of increasing doses of norepinephrine into the perfused foreleg there were progressive increments in total, arterial, small vessel, and venous resistances. In animals treated with reserpine the increments in total and small vessel resistances were greatly augmented while increments in segmental arterial resistance were increased only slightly. The venous responses in these treated dogs were not augmented. Similar effects on segmental resistances were noted with infusion of norepinephrine into a systemic vein. The vasoconstrictor effect of tyramine was reduced in treated dogs and was restored after intra-arterial and intravenous norepinephrine. The results indicate that veins do not participate in the increased vascular responsiveness to norepinephrine which occurs in forelegs of dogs after treatment with reserpine.

The Valeo stent: a pre-mounted, open-cell, large stent for use in small children with CHD

2015 ◽  
Vol 26 (6) ◽  
pp. 1187-1193 ◽  
Author(s):  
Frances C. Travelli ◽  
Patrick M. Sullivan ◽  
Cheryl Takao ◽  
Frank F. Ing
Keyword(s):  
Retrospective Analysis ◽  
Maximum Diameter ◽  
Cell Diameter ◽  
Small Children ◽  
Open Cell ◽  
Patient Profile ◽  
Systemic Vein ◽  
Low Profile ◽  
The Mean ◽  
Bench Testing

AbstractObjectivesThe aim of the present study was to determine the outcomes of using the Valeo stent (Bard Peripheral Vascular, Tempe, Arizona, United States of America) in small children with CHD.BackgroundStenting vascular stenoses is safe and effective in adults and older children with CHD but is limited in smaller children. The design of the Valeo stent addresses these limitations but has not been extensively described.MethodsBench testing was conducted to determine the maximum diameter of the stent, foreshortening, and side-cell diameter. A retrospective analysis of Valeo stents implanted between October, 2012 and October, 2014 was performed. Patient profile, pre-implant/post-implant catheterization data, and stent geometry were reviewed.ResultsBench testing: medium and large Valeo stents can be dilated up to 13 mm and 20 mm diameters, respectively. Side-cells are dilatable up to 12 mm. Valeo stents are of low profile – delivered through 6- or 7-Fr sheaths – and show minimal foreshortening. Retrospective analysis: a total of 81 stents were implanted in 61 patients with CHD. The median weight was 15.3 kg, and the median age was 58.9 months. Stents were implanted in the pulmonary artery, systemic vein, aorta, and pulmonary vein. Overall, mean vessel diameters increased from 4.1 to 7.7 mm (121.7%). There was effective mean gradient reduction: 3.7–0.5 mmHg (63%) in the venous systems, 28.2–12.5 mmHg (63.7%) in the pulmonary arteries, and 17.4–4 mmHg (77.1%) in the aorta. The mean stent foreshortening was 2.5%, and the mean recoil was 5.9%. Side-cells that crossed other vessels were dilated in four cases, and stents were re-mounted onto different-sized balloons in seven cases.ConclusionsThe features of the Valeo stent, such as low profile, large maximum diameter, open-cell design, minimal foreshortening, and recoil, make it suitable for treating vascular stenoses in small children with CHD.

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