Localized left atrial administration of tPA for the treatment of mechanical mitral valve thrombosis

2008 ◽  
Vol 72 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Sapna Desai ◽  
Clifford Kavinsky
Keyword(s):  
Mitral Valve ◽  
Left Atrial ◽  
Valve Thrombosis

How to Do It: Importance of Left Atrial Side Retraction in Robotic and Minimally Invasive Mitral Valve Surgery

2008 ◽  
Vol 11 (5) ◽  
pp. E270-E271 ◽  
Author(s):  
Norihiko Ishikawa ◽  
You Su Sun ◽  
L. Wiley Nifong ◽  
Go Watanabe ◽  
W. Randolph Chitwood
Keyword(s):  
Mitral Valve ◽  
Minimally Invasive ◽  
Left Atrial ◽  
Mitral Valve Surgery ◽  
Valve Surgery

scholarly journals Fluid–structure interaction in a fully coupled three-dimensional mitral–atrium–pulmonary model

2021 ◽  
Author(s):  
Liuyang Feng ◽  
Hao Gao ◽  
Nan Qi ◽  
Mark Danton ◽  
Nicholas A. Hill ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Left Atrium ◽  
Left Atrial ◽  
Left Atrial Appendage ◽  
Pulmonary Veins ◽  
Three Dimensional ◽  
Left Heart ◽  
Structure Interaction ◽  
Acute Mitral Regurgitation ◽  
Reversal Flow

AbstractThis paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation and acute mitral regurgitation). This is achieved by developing a complex computational framework for a coupled pulmonary circulation, left atrium and mitral valve model. The left atrium and mitral valve are modelled with physiologically realistic three-dimensional geometries, fibre-reinforced hyperelastic materials and fluid–structure interaction, and the pulmonary vessels are modelled as one-dimensional network ended with structured trees, with specified vessel geometries and wall material properties. This new coupled model reveals some interesting results which could be of diagnostic values. For example, the wave propagation through the pulmonary vasculature can lead to different arrival times for the second systolic flow wave (S2 wave) among the pulmonary veins, forming vortex rings inside the left atrium. In the case of acute mitral regurgitation, the left atrium experiences an increased energy dissipation and pressure elevation. The pulmonary veins can experience increased wave intensities, reversal flow during systole and increased early-diastolic flow wave (D wave), which in turn causes an additional flow wave across the mitral valve (L wave), as well as a reversal flow at the left atrial appendage orifice. In the case of atrial fibrillation, we show that the loss of active contraction is associated with a slower flow inside the left atrial appendage and disappearances of the late-diastole atrial reversal wave (AR wave) and the first systolic wave (S1 wave) in pulmonary veins. The haemodynamic changes along the pulmonary vessel trees on different scales from microscopic vessels to the main pulmonary artery can all be captured in this model. The work promises a potential in quantifying disease progression and medical treatments of various pulmonary diseases such as the pulmonary hypertension due to a left heart dysfunction.

scholarly journals EFFECT OF TRANSCATHETER MITRAL VALVE REPAIR ON LEFT ATRIAL KINETIC ENERGY IN CHRONIC MITRAL REGURGITATION

2021 ◽  
Vol 77 (18) ◽  
pp. 1756
Author(s):  
Michael Biersmith ◽  
Thura Harfi ◽  
David Orsinelli ◽  
Scott Lilly ◽  
Konstantinos Boudoulas
Keyword(s):  
Mitral Valve ◽  
Kinetic Energy ◽  
Mitral Regurgitation ◽  
Mitral Valve Repair ◽  
Left Atrial ◽  
Valve Repair ◽  
Transcatheter Mitral Valve Repair

What Factors Should Be Considered to Improve Outcome of Mechanical Mitral Valve Replacement in Children?

2021 ◽  
Vol 12 (3) ◽  
pp. 367-374
Author(s):  
Mohamed F. Elsisy ◽  
Joseph A. Dearani ◽  
Elena Ashikhmina ◽  
Prasad Krishnan ◽  
Jason H. Anderson ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Valve Replacement ◽  
Mitral Valve Replacement ◽  
Multivariable Analysis ◽  
Permanent Pacemaker ◽  
Early Mortality ◽  
Prosthetic Valve Thrombosis ◽  
Valve Size ◽  
Valve Thrombosis

Objective: To identify risk factors for pediatric mechanical mitral valve replacement (mMVR) to improve management in this challenging population. Methods: From 1993 to 2019, 93 children underwent 119 mMVR operations (median age, 8.8 years [interquartile range [IQR]: 2.1-13.3], 54.6% females) at our institution. Twenty-six (21.8%) patients underwent mMVR at ≤2 years and 93 (78.2%) patients underwent mMVR at >2 years. Median follow-up duration was 7.6 years [IQR: 3.2-12.4]. Results: Early mortality was 9.7%, but decreased with time and was 0% in the most recent era (13.9% from 1993 to 2000, 7.3% from 2001 to 2010, 0% from 2011 to 2019, P = .04). It was higher in patients ≤2 years compared to patients >2 years (26.9% vs 2.2%, P < .01). On multivariable analysis for mitral valve reoperation, valve size <23 mm was significant with a hazard ratio of 5.38 (4.87-19.47, P = .01);. Perioperative stroke occurred in 1% and permanent pacemaker was necessary in 12%. Freedom from mitral valve reoperation was higher in patients >2 years and those with a prosthesis ≥23 mm. Median time to reoperation was 7 years (IQR: 4.5-9.1) in patients >2 years and 3.5 years (IQR: 0.6-7.1) in patients ≤2 years ( P = .0511), but was similar between prosthesis sizes ( P = .6). During follow-up period (median 7.6 years [IQR: 3.2-12.4], stroke occurred in 10%, prosthetic valve thrombosis requiring reoperation in 4%, endocarditis in 3%, and bleeding in 1%. Conclusion: Early and late outcomes of mMVR in children are improved when performed at age >2 years and with prosthesis size ≥23 mm. These factors should be considered in the timing of mMVR.

1622: MECHANICAL MITRAL VALVE THROMBOSIS PRESENTING AS SEPTIC SHOCK

2016 ◽  
Vol 44 (12) ◽  
pp. 481-481
Author(s):  
Johann Patlak ◽  
Somnath Bose ◽  
Puja Shankar ◽  
Shahzad Shaefi
Keyword(s):  
Septic Shock ◽  
Mitral Valve ◽  
Valve Thrombosis
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