Late or very late stent thrombosis can also occur with bare metal stents

2007 ◽  
Vol 70 (2) ◽  
pp. 229-232 ◽  
Author(s):  
Andres Rosas Ramos ◽  
Marie-claude Morice ◽  
Thierry Lefèvre
Keyword(s):  
Stent Thrombosis ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis

scholarly journals Acute Coronary Syndrome after 17 Years of Bare Metal Stent Implantation: “Very” Very Late Stent Thrombosis

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Raghavendra Rao K ◽  
S. Reddy ◽  
J. R. Kashyap ◽  
K. Vikas ◽  
Hithesh Reddy ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Stent Thrombosis ◽  
Plaque Rupture ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Mortality And Morbidity ◽  
Coronary Syndrome

Very late stent thrombosis (VLST) is a catastrophic and life-threatening complication after percutaneous coronary intervention which presents as an acute coronary syndrome with significantly high mortality and morbidity. VLST is a rare entity with drug-eluting stents and even rarer with bare metal stents. The exact pathophysiologic mechanism of VLST after BMS implantation is not known although various mechanisms have been proposed. Recently, in-stent neoatherosclerosis with intimal plaque rupture has been proposed as a potential mechanism of VLST after BMS. We report a rare case of VLST occurring 17 years after BMS implantation with angiographic and intravascular imaging evidence which provides insight into the mechanisms of VLST.

scholarly journals Very Late Stent Thrombosis 42 Months after Implantation of Sirolimus-Eluting Stent and Discontinuation of Antiplatelet Therapy

2009 ◽  
Vol 2009 ◽  
pp. 1-2 ◽  
Author(s):  
Dirk Sibbing ◽  
Karl-Ludwig Laugwitz ◽  
Lorenz Bott-Flügel ◽  
Jürgen Pache
Keyword(s):  
Stent Thrombosis ◽  
Safety Concern ◽  
Bare Metal Stents ◽  
Drug Eluting Stent ◽  
Metal Stents ◽  
Late Stent Thrombosis ◽  
Stent Deployment ◽  
Very Late Stent Thrombosis ◽  
Drug Eluting ◽  
Sirolimus Eluting Stent

Although safety profiles of sirolimus-eluting stents do not seem to differ in short-to-medium term from those of bare-metal stents, late stent thrombosis after deployment of drug-eluting stents has emerged as a potential safety concern in the era of high-pressure stent implantation. Here, we describe the case of a patient with acute myocardial infarction due to stent thrombosis of a sirolimus-eluting stent 42 months after stent deployment and 5 weeks after discontinuation of aspirin treatment. To the best of our knowledge, this is one of the most delayed cases of sirolimus-eluting stent thrombosis described so far. The case emphasizes the potential risk that late stent thrombosis can unpredictably occur at any time point after drug-eluting stent deployment.

Abstract 17559: Ultra-Early Endothelialization of Biolimus A9 With Bioresorbable Polymer Stent (Nobori ® ) in Porcine Coronary Model: Possible Mechanism for Low Frequency of In-stent Thrombosis and Restenosis

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Masayuki Mori ◽  
Takuya Nakahashi ◽  
Shu Takabatake ◽  
Chiaki Nakanishi ◽  
Kenji Sakata ◽  
...  
Keyword(s):  
Stent Thrombosis ◽  
Early Phase ◽  
Low Frequency ◽  
Bare Metal Stents ◽  
Bare Metal Stent ◽  
Metal Stents ◽  
Bare Metal ◽  
Neointimal Thickness ◽  
Biolimus A9 ◽  
Bioresorbable Polymer

Background: The stent with biolimus A9 coated by a bioresorbable polymer (Nobori ® ) has the potential to reduce thrombosis by degradation of polymer over the period. However, few data exist regarding the vessel response and endothelialization at ultra-early phase after its implantation. Therefore, we examined ultra-early endothelialization of Nobori ® in porcine model. Methods and Results: Fifteen Nobori ® and 14 control bare-metal stents (S-Stent TM ) were implanted in 12 swine (mean weight 31.9 kg). Histopathological evaluation of stented segments were performed at 2 and 14 days after implantation. Morphometric analysis of the inflammation (graded as score 0 to 3) and the intimal fibrin content (graded as score 1 to 3) was also assessed. At 14 days, neointimal thickness and % neointimal area, defined as 100 х neointimal area / stent area, were significantly lower in Nobori ® than in S-Stent TM (51.4 ± 5.9 μm vs 76.4 ± 9.6 μm, p < 0.05 and 11.2 ± 1.1 % vs 15.7 ± 1.3 %, p < 0.01, respectively). Importantly, there were no significant differences in these parameters between 2 groups at 2 days (17.3 ± 6.1 μm vs 26.7 ± 6.1 μm, p = NS and 3.8 ± 1.3% vs 6.9 ± 1.7%, p = NS, respectively). Under these conditions, stent surface endothelialization evaluated by scanning electron microscope at 2 days showed similar appearance of endothelial coverage above the struts in Nobori ® compared with S-Stent TM (Figure). Furthermore, there were no significant differences in inflammatory (1.3 ± 0.1 vs 1.3 ± 0.1, p = NS) and intimal fibrin content (2.5 ± 0.1 vs 2.3 ± 0.1, p = NS) scores. Conclusion: These results demonstrated that endothelialization could occur at ultra-early phase after Nobori ® implantation with similar inflammatory reaction to bare-metal stent, probably contributing to low frequency of in-stent thrombosis and restenosis. The use of Nobori ® may have a potential benefit even at early phase before the degradation of polymer as well as long-term benefit.

scholarly journals Characteristics and prognosis of patients with angiographic stent thrombosis: comparison between drug-eluting and bare-metal stents

2008 ◽  
Vol 101 (4) ◽  
pp. 220-225 ◽  
Author(s):  
C. Le Feuvre ◽  
G. Helft ◽  
S. Cohen ◽  
J.-P. Batisse ◽  
O. Barthélémy ◽  
...  
Keyword(s):  
Stent Thrombosis ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal ◽  
Drug Eluting
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