Detection of vulnerable plaque in a murine model of atherosclerosis with optical coherence tomography

2006 ◽  
Vol 67 (6) ◽  
pp. 915-923 ◽  
Author(s):  
Mehmet Cilingiroglu ◽  
Jung Hwan Oh ◽  
Binu Sugunan ◽  
Nate J. Kemp ◽  
Jeehyun Kim ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Murine Model ◽  
Vulnerable Plaque ◽  
Optical Coherence

Optical coherence tomography and coronary angioscopy assessment of healed vulnerable plaque components in patients with coronary artery lesions undergoing elective percutaneous coronary intervention

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Kimura ◽  
K Hara ◽  
M Ohmori ◽  
R Tateishi ◽  
T Kaneda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
Vulnerable Plaque ◽  
Multivariate Logistic Regression Analysis ◽  
Low Grade ◽  
Optical Coherence ◽  
Coronary Artery Lesions ◽  
Coronary Syndrome ◽  
Yellow Plaque ◽  
Coronary Angioscopy

Abstract Background Many vulnerable plaques would progress without clinical events and might result in healed plaques (HPs). Histopathological or intracoronary image assessment of HPs has been reported. However, the morphological characteristics of HPs remain unclear yet. Purpose We sought to assess the healed vulnerable plaque components in patients with coronary artery lesions using optical coherence tomography (OCT) and coronary angioscopy (CAS). Methods We enrolled 47 patients with 50 native coronary artery lesions with angiographical severe stenosis (>90% diameter-stenosis) and without severe calcification (36 lesions with stable angina pectoris (SAP) and 14 acute coronary syndrome (ACS)) undergoing pre-intervention OCT and CAS. HPs was defined as layered phenotype on OCT. Lesion morphologies and plaque characteristics in lesions with HPs were assessed using OCT and CAS images. Results HPs were observed in 27 lesions (54.0%) and their prevalence were similar among each clinical status (SAP 52.8%, ACS 57.1%, p=1.00). Lesions with HPs had higher prevalence of OCT-macrophage (88.0% vs. 52.0%, p=0.01), CAS-red thrombus (88.8% vs. 52.2%, p=0.004) and CAS-low grade-yellow plaque (grade 1) (55.6% vs. 21.7%, p=0.02) than those without. SAP lesions with HPs had higher prevalence of CAS-yellow plaque (35.3% vs. 5.9%, p=0.09) and OCT-thin-cap fibroatheroma (42.1% vs. 5.9%, p=0.04) than SAP without HPs. ACS lesions with HPs had less CAS-red thrombus (0.0% vs. 50.0%, p=0.03) and OCT-plaque rupture (12.5% vs. 66.7%, p=0.04) than ACS without HPs. Multivariate logistic regression analysis revealed that OCT-macrophages (odds ratio (OR): 6.65, 95%-confidence intervals: 1.07–41.5, p=0.043), CAS-red thrombus (OR 8.77, 95% CI 1.33–57.8, p=0.02), and low grade-yellow plaque (OR 13.05, 95% CI 1.97–86.5, p=0.008) were independently related with the existence of HPs lesions. Combination of these 3 factors showed a high predictive value of OCT-HPs lesions (90.9%). Conclusions HPs lesions showed the lower lesion vulnerability than common ACS lesions but had more intraplaque inflammatory condition compared with common SAP lesions. Combined CAS and OCT examination might be useful to clarify the plaque components of HPs lesions in vivo, leading to help us understand the clinical significance of HPs. Funding Acknowledgement Type of funding source: None

scholarly journals Optical Coherence Tomography For the Detection of the Vulnerable Plaque

2016 ◽  
Vol 11 (2) ◽  
pp. 90 ◽  
Author(s):  
Konstantinos Toutouzas ◽  
Antonios Karanasos ◽  
Dimitris Tousoulis ◽  
◽  
◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Vulnerable Plaque ◽  
Optical Coherence

First Use of Optical Coherence Tomography on In Vivo Inflammatory Acne‐Like Lesions: A Murine Model

2019 ◽  
Vol 52 (3) ◽  
pp. 207-217 ◽  
Author(s):  
Maiko Hermsmeier ◽  
Tanvee Sawant ◽  
Khadiza Chowdhury ◽  
Usha Nagavarapu ◽  
Kin F. Chan
Keyword(s):  
Optical Coherence Tomography ◽  
Murine Model ◽  
Optical Coherence

scholarly journals Identification of Vulnerable Plaque in a Stented Coronary Segment 17 Years after Implantation Using Optical Coherence Tomography

2012 ◽  
Vol 53 (2) ◽  
pp. 450
Author(s):  
Jeong Hoon Yang ◽  
Kyeongmin Byeon ◽  
Hyeon-Cheol Gwon ◽  
Jeong Euy Park ◽  
Young Bin Song
Keyword(s):  
Optical Coherence Tomography ◽  
Vulnerable Plaque ◽  
Optical Coherence ◽  
Coronary Segment
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