Treatment of acute stent thrombosis with local urokinase therapy using catheter-based, drug delivery systems: A case report

1995 ◽  
Vol 34 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Joseph F. Mitchel ◽  
Raymond G. McKay
Keyword(s):  
Drug Delivery ◽  
Case Report ◽  
Stent Thrombosis ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Acute Stent Thrombosis

scholarly journals Intrathecal Pump Exposure to Electromagnetic Interference: A Report of Device Interrogation following Multiple ECT Sessions

2019 ◽  
Vol 19 (2;2) ◽  
pp. E343-E345
Author(s):  
Mark Bicket
Keyword(s):  
Drug Delivery ◽  
Case Report ◽  
Drug Delivery System ◽  
Delivery System ◽  
Electroconvulsive Therapy ◽  
Electromagnetic Interference ◽  
Drug Delivery Systems ◽  
Safety Issue ◽  
Delivery Systems ◽  
Intrathecal Drug Delivery

Background: Intrathecal drug delivery systems represent an increasingly common treatment modality for patients with a variety of conditions, including chronic pain and spasticity. Pumps rely on electronic programming to properly control and administer highly concentrated medications. Electromagnetic interference (EMI) is a known exposure that may cause a potential patient safety issue stemming from direct patient injury, pump damage, or changes to pump operation or flow rate. Objectives: The objective of our case report was to describe an approach to evaluating a patient with a pump prior to and following exposure to EMI from electroconvulsive therapy (ECT), as well as to document findings from device interrogations associated with this event. Study Design: Case report. Setting: Academic university-based pain management center. Results: We present the case of a patient with an intrathecal pump who underwent multiple exposures to EMI in the form of 42 ECT sessions. Interrogation of the intrathecal drug delivery system revealed no safety issues following ECT sessions. At no time were error messages, unintentional changes in event logs, unintentional changes in pump settings, or evidence of pump stall or over-infusion noted. Conclusion: Communication with multiple entities (patient, family, consulting physicians, and device manufacturer) and maintaining vigilance through device interrogation both before and after EMI exposure are appropriate safeguards to mitigate the risk and detect potential adverse events of EMI with intrathecal drug delivery systems. Given the infrequent reports of device exposure to ECT, best practices may be derived from experience with EMI exposure from magnetic resonance imaging (MRI). Although routine EMI exposure to intrathecal drug delivery systems should be avoided, we describe one patient with repeated exposure to ECT without apparent complication. Key words: Baclofen, intrathecal drug delivery system, electromagnetic interference, electroconvulsive therapy, safety, pump interrogation, intrathecal pump, pump stall

scholarly journals Implantable drug delivery systems with morphine in fibromyalgia -A case report-

2017 ◽  
Vol 12 (1) ◽  
pp. 91-94
Author(s):  
Yu Mi Ju ◽  
Sang Ho Shin ◽  
Shu Chung Choi ◽  
Jin Young Chon ◽  
Choon Ho Sung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Case Report ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Implantable Drug Delivery Systems

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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