The efficacy of using pulmonary vein wedge pressure for the estimation of pulmonary artery pressure in children with congenital heart disease

2003 ◽  
Vol 58 (2) ◽  
pp. 232-237 ◽  
Author(s):  
Manatomo Toyono ◽  
Kenji Harada ◽  
Masamichi Tamura ◽  
Kenji Yasuoka ◽  
Tomomi Oyama ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pulmonary Artery ◽  
Pulmonary Vein ◽  
Pulmonary Artery Pressure ◽  
Congenital Heart ◽  
Artery Pressure ◽  
Wedge Pressure

scholarly journals Effect of dexmedetomidine on pulmonary artery pressure in children with congenital heart disease and pulmonary hypertension

2020 ◽  
Vol 23 (4) ◽  
pp. 465
Author(s):  
Muralidhar Kanchi ◽  
DevdasThomas Inderbitzin ◽  
KadamNaina Ramesh ◽  
PujarVenkateshauarya Suresh ◽  
ShreeshaShankar Mayya ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Pulmonary Hypertension ◽  
Heart Disease ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Congenital Heart ◽  
Artery Pressure

Abstract 10188: Circulating Levels of MIF, GROα And RANTES Chemokines and Interleukin 17E Correlate With Severity of Pulmonary Hypertension in Young Pediatric Patients With Congenital Heart Disease

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Leína Zorzanelli ◽  
Nair Y Maeda ◽  
Mariana M Clavé ◽  
Ana M Thomaz ◽  
Marlene Rabinovitch ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Congenital Heart ◽  
Young Patients ◽  
Artery Pressure ◽  
Th2 Immune Response ◽  
Group 2 ◽  
Group 1

Introduction: Inflammation and immunity are central in the pathogenesis of pulmonary arterial hypertension (PAH), but have not been fully explored in young patients with congenital heart disease and elevated pulmonary artery pressure (PAH-CHD) undergoing surgical repair. Hypothesis: Cytokines and related proteins may be differentially expressed in PAH-CHD patients with distinct hemodynamic patterns. Methods: Sixteen patients with PAH-CHD were enrolled (Group 1, age 1.13 (0.76-2.48) years, median and interquartile range). Pulmonary artery pressure was 52 (43-66) mmHg, and pulmonary vascular resistance was 5.2 (4.2-8.9) Wood units•m 2 . Patients with pulmonary overcirculation, with no need for cardiac catheterization were included for comparison (Group 2, N=31, age 0.71 (0.43-1.02) years). Pulmonary-to-systemic blood flow ratio (echocardiography) in Group 1 and Group 2 was 1.9 (1.3-2.6) and 2.8 (2.3-3.3) respectively (p=0.008). Thirty-six cytokines were analyzed in serum using a chemiluminescence array. Results: In the whole patient group (N=47), MIF chemokine (macrophage migration inhibitory factor) was significantly increased compared to pediatric controls (respective densities 7510±2755 pixels and 5697±2051 pixels, mean±SD, p=0.027). In patients, GROα chemokine (growth-regulated oncogene alpha) was elevated early in life, but decreased exponentially with the age (R 2 =0.21, p=0.001), while interleukin 17E (also called IL-25) increased progressively (R 2 =0.24, p<0.001). MIF was specifically increased in Group 1 compared to Group 2 and controls (respectively, 8494±619 pixels, 6618±477 pixels and 6548±726 pixels, age-adjusted mean±SEM, p=0.037). In contrast, RANTES chemokine (regulated on activation, normal T cell expressed and secreted) was specifically elevated in Group 2 compared to Group 1 and controls (respectively, 74183±3865 pixels, 60130±6455 pixels and 59332±3970 pixels, mean±SEM, p=0.039). Conclusion: The data indicate a relationship between cytokine levels and severity of the disease (age, groups), with potential pathophysiological implications. Furthermore, involvement of interleukin 17E and MIF emphasize the role of Th2 immune response already described in PAH.

Cardiac catheterization

2017 ◽  
Author(s):  
Sara Thorne ◽  
Sarah Bowater
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Vascular Resistance ◽  
Cardiac Catheterization ◽  
Congenital Heart ◽  
Normal Values ◽  
Artery Pressure ◽  
Complex Anatomy

The purpose of cardiac catheterization in patients with congenital heart disease is to gain information about complex anatomy and haemodynamics, especially with respect to pulmonary artery pressure and vascular resistance. This chapter outlines indications for cardiac catheterization, precatheterization care, normal values and calculations, and catheter interventions in ACHD.

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