What is the optimal time to initiate antiretroviral therapy in treatment-naive adults with asymptomatic HIV infection?

2015 ◽  
Author(s):  
Edith Angel-Müller
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Optimal Time ◽  
Treatment Naïve ◽  
Asymptomatic Hiv

scholarly journals Plasma lipidome abnormalities in people with HIV initiating antiretroviral therapy

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Emily R. Bowman ◽  
◽  
Manjusha Kulkarni ◽  
Janelle Gabriel ◽  
Xiaokui Mo ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Immune Activation ◽  
Plasma Lipids ◽  
Inflammatory Biomarkers ◽  
Cvd Risk ◽  
Art Initiation ◽  
Lipid Species ◽  
Treatment Naïve

Abstract Background Dyslipidemia often accompanies human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART). Lipid abnormalities likely contribute to increased cardiometabolic disease among people with HIV (PWH). Here, we expand our previous findings on changes in the lipidome following ART initiation, and associations among lipid species, including ceramides (CER), diacylglycerols (DAG), and triacylglycerols (TAG), with immune activation. Methods Concentrations and fatty acid composition of plasma lipids (~ 1300 species) were measured by differential mobility spectroscopy in samples from 35 treatment-naïve PWH pre- and post-initiation of ART (raltegravir (RAL)/tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC)); lipidomes were compared to those found in demographically similar HIV-uninfected individuals (n = 13). Results Compared to people without HIV, 37.1% of all lipid species measured were altered in PWH at baseline, and 31.8% of lipid species were altered following 48 weeks of ART. Concentrations of lipid classes were also altered in PWH; diacylglycerols (DAGs) and triacylglycerols (TAGs) were increased at baseline, and DAGs remained increased after 48 weeks of ART. Lipids previously linked to cardiovascular disease (CVD) and diabetes were enriched in PWH pre- and post ART, and were related to immune activation and insulin resistance scores. Polyunsaturated fatty acid (PUFA)-containing lipids were lower in PWH compared to levels in controls, and were inversely related to levels of inflammatory biomarkers. Conclusions HIV infection and ART initiation both induce cardiometabolic changes to the composition of the plasma lipidome. These alterations are associated with inflammatory biomarkers, and may directly contribute to elevated CVD risk and diabetes. Trial registration This study is registered with Clinicaltrials.gov (NCT00660972). Registered April 16, 2008.

Efficacy, Safety, and Tolerability of Long-Term Combination Antiretroviral Therapy in Asymptomatic Treatment-Naïve Adults with Early HIV Infection

2007 ◽  
Vol 8 (5) ◽  
pp. 269-281 ◽  
Author(s):  
Deborah K. McMahon ◽  
Mark J. DiNubile ◽  
Anne R. Meibohm ◽  
Deborah R. Marino ◽  
Michael N. Robertson ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Combination Antiretroviral Therapy ◽  
Treatment Naïve

HIV Increases Mean Platelet Volume During Asymptomatic HIV Infection in Treatment-Naive Patients

2011 ◽  
Vol 57 (5) ◽  
pp. e112-e113 ◽  
Author(s):  
Álvaro Mena ◽  
Héctor Meijide ◽  
Pilar Vázquez ◽  
Ángeles Castro ◽  
Soledad López ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Treatment Naïve ◽  
Asymptomatic Hiv
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