Which regimen is most effective at improving outcomes in critically ill adults with hospital-acquired pneumonia: short-course or prolonged-course antibiotic therapy?

2013 ◽  
Keyword(s):  
Antibiotic Therapy ◽  
Critically Ill ◽  
Short Course ◽  
Hospital Acquired Pneumonia ◽  
Critically Ill Adults ◽  
Hospital Acquired ◽  
Ill Adults

scholarly journals Correction to: Procalcitonin-guided antibiotic therapy in critically ill adults: a meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Zhang ◽  
Yan Wang ◽  
Qianting Yang ◽  
Yalin Dong
Keyword(s):  
Antibiotic Therapy ◽  
Critically Ill ◽  
Meta Analysis ◽  
Software Developers ◽  
Critically Ill Adults ◽  
Ill Adults

After publication of the original article [1], the authors have reported that the software developers had used a new amended version of the software called “v0.9.5.10” instead of “v0.9.5.5”, which is referred to in the original article.

scholarly journals Is Early Oral Antimicrobial Switch Useful for Less Critically Ill Adults with Community-Onset Bacteraemia in Emergency Departments?

Antibiotics ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 807
Author(s):  
Ching-Chi Lee ◽  
Po-Lin Chen ◽  
Chih-Chia Hsieh ◽  
Chao-Yung Yang ◽  
Chih-Hao Lin ◽  
...  
Keyword(s):  
Critically Ill ◽  
Antimicrobial Therapy ◽  
Cost Effective ◽  
Source Control ◽  
Short Course ◽  
Hospitalised Patients ◽  
Empirical Antibiotics ◽  
Critically Ill Adults ◽  
Ill Adults ◽  
Community Onset

To compare prognoses and adverse events between bacteraemic patients in the emergency department (ED) who received an early antimicrobial IV-to-PO switch and those treated with late or no IV-to-PO switch, an 8-year multicentre cohort consisting of adults with community-onset bacteraemia was conducted. The clinical characteristics and outcomes were compared in matched cohorts by the closest propensity score calculated based on the independent determinants of 30-day mortality identified by the multivariate regression model. Of the 6664 hospitalised patients who received no or late IV-to-PO switch, 2410 were appropriately matched with 482 patients treated with early IV-to-PO switch and discharged from the ED. There were no significant differences between the two matched groups in their baseline characteristics, including the patient demographics, severity and types of comorbidities, severity and sources of bacteraemia, and the 15- and 30-day mortality rates. Notably, in addition to the shorter lengths of intravenous antimicrobial administration and hospital stay, less phlebitis and lower antimicrobial costs were observed in patients who received an early IV-to-PO switch. Similarity was observed in the clinical failure rates between the two groups. Furthermore, the inappropriate administration of empirical antibiotics and inadequate source control were identified as the only independent determinants of the post-switch 30-day crude mortality in patients who received an early IV-to-PO switch. In conclusion, for less critically ill adults with community-onset bacteraemia who received appropriate empirical antimicrobial therapy and adequate source control, an early IV-to-PO switch might be safe and cost-effective after a short course of intravenous antimicrobial therapy.

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