For adults with systemic lupus erythematosus (SLE) and cutaneous disease, what are the effects of intravenous (IV)/subcutaneous (SC) monoclonal antibodies?

2021 ◽  
Author(s):  
Agustín Ciapponi
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Monoclonal Antibodies ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Cutaneous Disease

Progress with the use of monoclonal antibodies for the treatment of systemic lupus erythematosus

Immunotherapy ◽  
2015 ◽  
Vol 7 (3) ◽  
pp. 255-270 ◽  
Author(s):  
Natasha Jordan ◽  
Pamela MK Lutalo ◽  
David P D’Cruz
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Monoclonal Antibodies ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals Monoclonal antibodies RB139 and RB142 recognize citrullinated LL37 by immunofluorescence in histological sections in Systemic lupus erythematosus (SLE) and Rheumatoid arthritis (RA)

2020 ◽  
Vol 3 (4) ◽  
pp. e236
Author(s):  
Roberto Lande ◽  
Stefano Alivernini ◽  
Barbara Tolusso ◽  
Francesca Spadaro ◽  
Mario Falchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Monoclonal Antibodies ◽  
Epithelial Cells ◽  
Lupus Erythematosus ◽  
Human Tissues ◽  
Systemic Lupus ◽  
Exact Localization ◽  
Health And Disease ◽  
Pleiotropic Functions

LL37 is a natural antibiotic, but is also a molecule with pleiotropic functions as well as an immune-modulator. LL37 is produced by epithelial cells and is present in neutrophils’ granules. LL37 alone, or in complex with DNA, can activate inflammatory pathways in psoriasis, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this work, we describe the capacity of two recombinant monoclonal antibodies, RB139 and RB142, previously shown to specifically recognize LL37 in its citrullinated form (cit-LL37) by ELISA, to detect LL37 by immunofluorescence in human inflamed tissues derived from SLE and RA patients. Such antibodies represent previously unavailable tools to detect the presence, the citrullinated state and the exact localization of cit-LL37 in human tissues in health and disease.

scholarly journals Monoclonal Antibodies for Systemic Lupus Erythematosus (SLE)

2010 ◽  
Vol 3 (1) ◽  
pp. 300-322 ◽  
Author(s):  
Claudio Ponticelli ◽  
Gabriella Moroni
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Monoclonal Antibodies ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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