For adults with suspicious skin lesions, can smartphone applications (apps) accurately rule out cutaneous invasive melanoma and atypical intraepidermal melanocytic variants?

2020 ◽  
Author(s):  
Jane Burch ◽  
Margit Polcz
Keyword(s):  
Skin Lesions ◽  
Smartphone Applications ◽  
Rule Out

scholarly journals Smartphone applications for triaging adults with skin lesions that are suspicious for melanoma

2018 ◽  
Author(s):  
Naomi Chuchu ◽  
Yemisi Takwoingi ◽  
Jacqueline Dinnes ◽  
Rubeta N Matin ◽  
Oliver Bassett ◽  
...  
Keyword(s):  
Skin Lesions ◽  
Smartphone Applications

scholarly journals A novel total body digital photography smartphone application designed to detect and monitor skin lesions: a pilot study

2018 ◽  
Vol 3 (2) ◽  
Author(s):  
Nicholas Guido ◽  
Erika L. Hagstrom ◽  
Erin Ibler ◽  
Chantelle Carneiro ◽  
Kelsey A. Orrell ◽  
...  
Keyword(s):  
Decision Making ◽  
High Sensitivity ◽  
Smartphone Application ◽  
Skin Lesions ◽  
Smartphone Applications ◽  
Self Monitoring ◽  
Pigmented Lesions ◽  
Naturally Occurring ◽  
Total Body ◽  
New Skin

<p class="Body">Although some smartphone applications are designed for total body photography (TBP), few offer the specificity that enables self- as well as dermatologist-, detection of new lesions, or change in lesion color or in size as little as 1mm, on an ongoing basis. The aim of this study is to assess the sensitivity of a novel TBP application in the detection of changes to color and size of simulated skin lesions. Twenty-five subjects underwent one study visit. After baseline photography, new artificial markings were made or naturally occurring pigmented lesions located in any anatomical region were enhanced/enlarged, and a second matching set of photographs was then taken. From all 25 subjects, a total of 262 skin markings were evaluable. Of these, 241 (92%) were detected by the app, which resulted in an overall sensitivity of 92%. The high sensitivity establishes the app as capable of providing reliable self-TBP that allows detection and monitoring of new skin lesions or change in both size and color. This method greatly enhances the ability to accomplish ongoing self-monitoring and yet provides quality informing images to the dermatologist to assist in decision-making with the patient. </p>

scholarly journals Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Ugur Uslu ◽  
Franz Heppt ◽  
Michael Erdmann
Keyword(s):  
Correct Diagnosis ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Melanocytic Nevus ◽  
Careful Examination ◽  
Acral Lentiginous Melanoma ◽  
Melanoma In Situ ◽  
Malignant Skin ◽  
Rule Out

Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ. Since clinical and dermoscopic examinations did not rule out a malignant skin lesion, surgical excision was performed and confirmed an intracorneal hematoma. In summary, without adequate physical trigger, it may be clinically and dermoscopically challenging to make the correct diagnosis in pigmented palmar and plantar skin alterations. Thus, biopsy or surgical excision of the skin alteration may be necessary to rule out melanoma.

scholarly journals Aneurysmal fibrous histiocytoma

2019 ◽  
Vol 7 (10) ◽  
pp. 3906
Author(s):  
Istan Irmansyah Irsan ◽  
Thomas Erwin C. J. Huwae ◽  
Satria Pandu Persada Isma ◽  
Agung Riyanto Budi Santoso ◽  
Hanindya Prasojo
Keyword(s):  
Fibrous Histiocytoma ◽  
Excisional Biopsy ◽  
Skin Lesions ◽  
Wide Excision ◽  
Loss Of Function ◽  
Diagnostic Challenge ◽  
Late Treatment ◽  
History Of ◽  
Cd 68 ◽  
Rule Out

Aneurysmal fibrous histiocytoma is rare clinicopathological variant of Cutaneous Fibrous Histiocytoma. The clinical manifestation of Aneurysmal Fibrous Histiocytoma is often confusing to distinguish from other skin lesions. Most of the cases showed rapid increase in size or a history of recurrence, however histologically all are almost similar. Rarity of aneurysmal fibrous histiocytoma and high numbers of recurrence rate poses a big diagnostic challenge. Late treatment will result in a decrease until loss of function of the affected region.  In this article, author reported the case of aneurysmal fibrous histiocytoma of the hand in 7 years old girl with restricted at 2nd-3rd metacarpophalangeal joints. The patient had undergone a series of investigations until finally a wide excision was carried out. Excision tissue was performed CD 68 and CD 34  immunocytochemical smear to establish the diagnosis. It was not simple to make diagnosis aneurysmal fibrous histiocytoma. While it is benign, the lesion can appear malignant, and one should consider an excisional biopsy to rule out malignant conditions. The diagnosis had to be confirmed by histopathological and performed immunocytochemical smear. It was often necessary to take aggressive actions with wide excision and reconstruction.

scholarly journals Erythema Ab Igne with Histological Features of Keratosis Lichenoides Chronica

2021 ◽  
pp. 184-189
Author(s):  
Asja Prohic ◽  
Selma Poparic ◽  
Adem Cemerlic ◽  
Aida Kapetanovic
Keyword(s):  
Heat Source ◽  
Prolonged Exposure ◽  
Heat Exposure ◽  
Clinical History ◽  
Skin Lesions ◽  
Histological Features ◽  
Malignant Skin ◽  
Erythema Ab Igne ◽  
Malignant Alteration ◽  
Rule Out

Erythema ab igne (EAI) is a localized, hyperpigmented and reticulated dermatosis at sites of chronic heat exposure. Within longstanding skin lesions of EAI, hyperkeratotic lesions may emerge and can potentially transform into pre-malignant or malignant skin lesions. A 55-year-old woman presented for the evaluation of multiple hyperkeratotic lesions along with a reticular patterned hyperpigmentation on her right knee, an area that had repeated and prolonged exposure to a heat source over a period of several months. Based on her clinical history and the physical examination of her lesions, she was diagnosed as having a hyperkeratotic form of EAI. A skin biopsy was performed to rule out malignant alteration, but the histopathological findings were supportive of keratosis lichenoides chronica.

Neck Melanoma: Clinical, Dermoscopic and Confocal Features

Dermatology ◽  
2019 ◽  
Vol 236 (3) ◽  
pp. 241-247
Author(s):  
Stefania Borsari ◽  
Riccardo Pampena ◽  
Margherita Raucci ◽  
Marica Mirra ◽  
Simonetta Piana ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Head And Neck ◽  
Skin Lesions ◽  
Lentigo Maligna ◽  
Diagnostic Features ◽  
Neck Area ◽  
Lentigo Maligna Melanoma ◽  
Melanoma Patients ◽  
Grey Colour ◽  
Rule Out

Background: The head and neck are considered one single anatomical unit. No data on clinical, dermoscopic and confocal aspects of neck melanoma are currently available. Objectives: To identify clinical, dermoscopic and confocal diagnostic features of neck melanomas. Methods: Consecutive malignant (cases) and benign (controls) melanocytic skin lesions located on the neck, excised as suspected of being melanoma from March 2011 to February 2018, were retrospectively retrieved. Dermoscopic criteria of the 7-point checklist, integrated by other melanoma features (such as grey colour and irregular hyperpigmented areas) were assessed. Reflectance confocal microscopy (RCM) images were examined when available. Results: 282 lesions located to the head and neck area were biopsied to rule out melanoma. Thirty-one out of 282 (11%) lesions were located on the neck: 21 melanomas and 10 naevi. Melanoma patients were older than patients with naevi (mean age: 60.4 vs. 37.9 years, p < 0.001). Neck melanomas were more frequently located on sun-damaged skin compared to naevi (76.2 vs. 30%, p = 0.02). Dermoscopically, neck melanomas were characterized by irregular dots/globules, grey colour and regression (76.2, 81 and 46.7% of cases) and showed criteria of lentigo maligna melanoma (LMM) in 52.4% of cases. Regression, grey colour, irregular hyperpigmented areas and criteria of LMM typified melanomas on sun-damaged skin, whereas tumours located on non-sun-damaged areas were often characterized by irregular pigmentation (blotches). RCM, implemented to dermoscopy, correctly diagnosed 10/12 melanomas and 3/5 naevi. Conclusion: Neck melanoma has peculiar clinical and dermoscopic aspects that could help clinicians to distinguish it from naevi and to diagnose melanoma earlier.

scholarly journals Cutaneous Endometriosis: A Case Report

2021 ◽  
Vol 5 (3) ◽  
pp. 307-310
Author(s):  
Alan Wong ◽  
Stefanie Altmann ◽  
Karthik Krishnamurthy
Keyword(s):  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Skin Lesions ◽  
Cutaneous Metastasis ◽  
Diagnostic Challenge ◽  
Cutaneous Lesions ◽  
Cutaneous Endometriosis ◽  
Sister Mary Joseph ◽  
Work Up ◽  
Rule Out

Cutaneous endometriosis (CEM) is a rare disease characterized by endometrial glands and/or stroma in the skin. Lesions present as a firm papule or nodule and can be blue, violaceous, red, brown or skin-colored. Patients frequently report cyclical tenderness, swelling and bleeding at the site of the lesion related to their menstrual cycle. CEM presents a diagnostic challenge as lesions are commonly mistaken for a keloid, dermatofibroma, dermatofibrosarcoma protuberans, melanoma or cutaneous metastasis of cancer (e.g., Sister Mary Joseph nodule). A biopsy must be taken to rule out malignancy and treatments include surgical excision and hormonal agents. To our knowledge, just over 100 cases have been reported in the literature. Herein we highlight a case of CEM in a 43-year-old female that presented to dermatology after being overlooked on prior work-up with obstetrics and gynecology. This case highlights the need for dermatologists to be familiar with CEM, as we may be the first clinicians these patients present to for painful cutaneous lesions.

Fine Structural Alterations in Thyroid Follicular Cells (FC) and Changes in Serum Thyroxine Produced by Feeding Polychlorinated Biphenyl (PCB) to Rats

1977 ◽  
Vol 35 ◽  
pp. 498-499
Author(s):  
W.T. Collins ◽  
Charles C. Capen ◽  
Louis Kasza
Keyword(s):  
Feed Efficiency ◽  
Polychlorinated Biphenyl ◽  
Serum Proteins ◽  
Skin Lesions ◽  
Hepatic Necrosis ◽  
Ultrastructural Changes ◽  
Lymphoid Tissues ◽  
Heat Transfer Fluids ◽  
Thyroid Follicular Cells ◽  
Peripheral Metabolism

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.

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