In people with primary cutaneous melanoma, how do surgical excision margins affect outcomes?

2016 ◽  
Author(s):  
Patricia Louise Danielsen
Keyword(s):  
Cutaneous Melanoma ◽  
Surgical Excision ◽  
Primary Cutaneous Melanoma ◽  
Excision Margins

scholarly journals Surgical excision margins for primary cutaneous melanoma

2009 ◽  
Author(s):  
Michael J Sladden ◽  
Charles Balch ◽  
David A Barzilai ◽  
Daniel Berg ◽  
Anatoli Freiman ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Surgical Excision ◽  
Primary Cutaneous Melanoma ◽  
Excision Margins

2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial

The Lancet ◽  
2019 ◽  
Vol 394 (10197) ◽  
pp. 471-477 ◽  
Author(s):  
Deborah Utjés ◽  
Jonas Malmstedt ◽  
Jüri Teras ◽  
Krzysztof Drzewiecki ◽  
Hans Petter Gullestad ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Randomised Trial ◽  
Surgical Excision ◽  
Primary Cutaneous Melanoma ◽  
Long Term Follow Up ◽  
Excision Margins

Excision Margin and Survival in Patients with High-Risk, Primary Cutaneous Melanoma: A Retrospective Study Based on Surveillance Epidemiology and End Result (SEER) Database

Dermatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Meng-Nan Xu ◽  
Qiu Rao
Keyword(s):  
High Risk ◽  
Cutaneous Melanoma ◽  
Primary Melanoma ◽  
Surgical Excision ◽  
Primary Cutaneous Melanoma ◽  
Term Survival ◽  
Wide Margin ◽  
Excision Margin ◽  
Therapeutic Benefits ◽  
Excision Margins

<b><i>Objectives:</i></b> The optimal excision margin of primary cutaneous melanoma greater than 2 mm in thickness is still a controversial topic. The aim of the present study was to compare the long-term survival between narrow and wide excision margins in the surgical excision of patients with high-risk primary melanoma. <b><i>Methods:</i></b> We chose the patients with primary melanoma of the skin thicker than 2 mm in The Surveillance, Epidemiology, and End Results database. Patients were divided into a narrow margin group (1–2 cm) and a wide margin group (&#x3e;2 cm) according to the resection margin information. The primary outcome was overall survival and disease-specific survival. <b><i>Results:</i></b> From 2004 to 2015, a total of 2,772 patients diagnosed as having melanoma of the skin were recruited into this study and were assigned to the narrow margin group (<i>n</i> = 1996) and the wide margin group (<i>n</i> = 776). A total of 1,098 patients died during the follow-up, and 681 of these were due to melanoma. There were 779 deaths in the narrow margin group and 319 deaths in the wide margin group (HR: 0.96, 95% CI: 0.84–1.10, <i>p</i> = 0.26). A total of 490 melanoma-specific deaths were reported in the narrow margin group and 191 were reported in the wide margin group (HR: 1.01, 95% CI: 0.85–1.19, <i>p</i> = 0.91). <b><i>Conclusions:</i></b> Wider excision margin greater than 2 cm did not provide any additional therapeutic benefits compared to narrow excision margin between 1 and 2 cm. A 2-cm margin is adequate and safe for high-risk primary melanoma of the skin thicker than 2 mm.

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