What are the benefits and harms of epidermal growth factor receptor (EGFR) blockers for the treatment of ovarian cancer after first-line therapy?

2019 ◽  
Author(s):  
Husein Husein-ElAhmed ◽  
Sera Tort
Keyword(s):  
Ovarian Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Epidermal Growth

scholarly journals ASCO Provisional Clinical Opinion: Epidermal Growth Factor Receptor Mutation Testing in Practice

2011 ◽  
Vol 7 (3) ◽  
pp. 202-204 ◽  
Author(s):  
Mary Beth Beasley ◽  
Daniel T. Milton
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Advanced Nsclc ◽  
Growth Factor Receptor ◽  
Mutation Testing ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Epidermal Growth

ASCO has recently provided guidance on emerging data on EGFR testing for the purpose of selecting first-line therapy for persons with advanced NSCLC through its Provisional Clinical Opinion.

Phase III Randomized Study Comparing Docetaxel Plus Trastuzumab With Vinorelbine Plus Trastuzumab As First-Line Therapy of Metastatic or Locally Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: The HERNATA Study

2011 ◽  
Vol 29 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Michael Andersson ◽  
Elisabeth Lidbrink ◽  
Karsten Bjerre ◽  
Erik Wist ◽  
Kristin Enevoldsen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
First Line ◽  
Human Epidermal Growth Factor ◽  
First Line Therapy ◽  
Line Therapy ◽  
Epidermal Growth

PurposeTo evaluate docetaxel or vinorelbine, both with trastuzumab, as first-line therapy of human epidermal growth factor receptor 2–positive advanced breast cancer.Patients and MethodsPatients naive to chemotherapy for advanced disease were randomly assigned to docetaxel 100 mg/m2day 1 or vinorelbine 30 to 35 mg/m2on days 1 and 8, both combined with trastuzumab (8-mg/kg loading dose and 6-mg/kg maintenance dose) on day 1 every 3 weeks. The primary end point was time to progression (TTP).ResultsA total of 143 patients were randomly allocated to docetaxel, and 141 patients were assigned to vinorelbine. The median TTP for docetaxel and vinorelbine respectively was 12.4 months versus 15.3 months (hazard ratio [HR] = 0.94; 95% CI, 0.71 to 1.25; P = .67), median overall survival was 35.7 months versus 38.8 months (HR = 1.01; 95% CI, 0.71 to 1.42; P = .98), and the 1-year survival rate was 88% in both arms. Median time to treatment failure for study chemotherapy was 5.6 months versus 7.7 months (HR = 0.50; 95% CI, 0.38 to 0.64; P < .0001). The investigator-assessed overall response rate among 241 patients with measurable disease were 59.3% in both arms. More patients in the docetaxel arm discontinued therapy due to toxicity (P < .001). Significantly more treatment-related grade 3 to 4 febrile neutropenia (36.0% v 10.1%), leucopenia (40.3% v 21.0%), infection 25.1% v 13.0%), fever (4.3% v 0%), neuropathy (30.9% v 3.6%), nail changes (7.9% v 0.7%), and edema (6.5% v 0%) were reported with docetaxel.ConclusionThe study failed to demonstrate superiority of any drug in terms of efficacy, but the vinorelbine combination had significantly fewer adverse effects and should be considered as an alternative first-line option.

Sign in / Sign up

Export Citation Format

Share Document