How does adding umbilical artery Doppler to fetal growth (biometry) for surveillance of twin pregnancies compare with biometry alone?

2018 ◽  
Author(s):  
Jane Burch ◽  
Juliana Ester Martin-Lopez
Keyword(s):  
Fetal Growth ◽  
Umbilical Artery ◽  
Umbilical Artery Doppler ◽  
Twin Pregnancies

scholarly journals Placental glucose transporter 1 and 3 gene expression in Monochorionic twin pregnancies with selective fetal growth restriction

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yao-Lung Chang ◽  
An-Shine Chao ◽  
Shuenn-Dyh Chang ◽  
Po-Jen Cheng
Keyword(s):  
Gene Expression ◽  
Fetal Growth ◽  
Twin Pregnancy ◽  
Umbilical Artery ◽  
Expression Ratio ◽  
Gene Expression Ratio ◽  
Umbilical Artery Doppler ◽  
Group 2 ◽  
Twin Pregnancies ◽  
Group 1

Abstract Background In monochorionic twin (MC) gestations with selective fetal growth restriction (FGR), the discordant fetal growth usually is due to unequal placental sharing. Glucose, which is essential for oxidative metabolism in the growing placenta and fetus, is transferred from maternal blood by facilitated carrier-mediated diffusion via glucose transporters (GLUTs). How the GLUTs expression varies in the two placenta territories manifests discordant perfusion in MC twin pregnancy with selective FGR is unknown. This study evaluates the human placental GLUT1 and GLUT3 gene expression in MC twin gestations with selective FGR. Methods MC twin pregnancy with selective FGR was defined as the presence of inter-twin birth weight discordance of > 25% and the smaller twin with a birth weight less than the 10th percentile in third trimester. Fetal umbilical artery Doppler was checked within 1 week before delivery in the two fetuses. An abnormal umbilical artery Doppler was defined as persistently absent or reverse end-diastolic flow (UA-AREDF). GLUT1, GLUT3 and HIF-1α gene expression were assayed in each twin’s placental territories. The inter-twin placental gene expression ratio was calculated as the placenta GLUTs or HIF-1α expression level of the selective FGR twin divided by expression level of the appropriate-for-gestational-age (AGA) cotwin. Higher gene expression ratio means elevated gene expression in the selective FGR twin’s placenta territory compared to AGA twin’s placenta territory. Results 15 MC twin gestations with selective FGR including nine with normal (group 1) and six with abnormal selective FGR twin UA Doppler (group 2) were included into this study. The GLUT3 and HIF-1α gene expression are significantly elevated in selective FGR twin’s placenta territory in group 2 twin pregnancies (mean gene expression ratio as 2.23 and 1.65, p values as 0.015 and 0.045, respectively), but not in in group 1 twin pregnancies. Conclusion The upregulation of placental GLUT3 gene expression in selective FGR fetus with abnormal UA Doppler may be due to hypo-perfusion which is mediated by up -regulation of HIF-1α gene expression.

753 Umbilical artery doppler improvement after steroid administration is associated with improved fetal growth

2021 ◽  
Vol 224 (2) ◽  
pp. S471-S472
Author(s):  
Katherine H. Bligard ◽  
Bree A. Porcelli ◽  
Jeffrey Dicke ◽  
Diana Gray ◽  
Roxane M. Rampersad ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Umbilical Artery ◽  
Steroid Administration ◽  
Umbilical Artery Doppler

Umbilical artery Doppler changes in fetal growth restriction with intermittently absent umbilical artery end-diastolic flow

2022 ◽  
Vol 226 (1) ◽  
pp. S386-S387
Author(s):  
Eileen Xu ◽  
Nandini Raghuraman ◽  
Katherine H. Bligard ◽  
Jeffrey Dicke ◽  
Anthony O. Odibo ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Umbilical Artery ◽  
Growth Restriction ◽  
Diastolic Flow ◽  
Umbilical Artery Doppler

Perinatal Outcome of Monochorionic Twins With Selective IUGR Compared With Uncomplicated Monochorionic Twins

2011 ◽  
Vol 14 (5) ◽  
pp. 457-462 ◽  
Author(s):  
Boaz Weisz ◽  
Liat Hogen ◽  
Yoav Yinon ◽  
Liat Gindes ◽  
Alon Shrim ◽  
...  
Keyword(s):  
Perinatal Outcome ◽  
Umbilical Artery ◽  
Perinatal Outcomes ◽  
Monochorionic Twins ◽  
Group A ◽  
Umbilical Artery Doppler ◽  
Group B ◽  
A Prospective Study ◽  
Gestational Age At Birth ◽  
Twin Pregnancies

Objective: To evaluate the perinatal outcome of MC twins with selective IUGR (sIUGR).Study design: A prospective study, which included three groups of MC twins: Group A, uncomplicated MC twin pregnancies (n = 91); group B, sIUGR with normal umbilical artery Doppler (n = 19); and group C, sIUGR with abnormal (absence or reversed EDV) umbilical artery Doppler (n = 18). The latter were routinely hospitalized in the high-risk ward under strict surveillance.Results: Neonatal outcome of fetuses complicated with sIUGR and normal Doppler was similar to controls. Neonates born to pregnancies complicated by sIUGR and abnormal Doppler had significantly increased incidence of CNS findings, RDS, NEC, sepsis, and neonatal death compared to controls. Adverse outcome in this group was independently associated only with gestational age at birth.Conclusion: The perinatal outcomes of MC twins complicated with sIUGR and normal Doppler are similar to uncomplicated MC pregnancies. MC twins with sIUGR and abnormal Doppler have reasonable outcomes, yet significantly more neonatal complications compared to non-complicated MC twins.

Placental histopathological correlates of umbilical artery Doppler velocimetry in pregnancies complicated by fetal growth restriction

2012 ◽  
Vol 32 (13) ◽  
pp. 1263-1272 ◽  
Author(s):  
Arsenio Spinillo ◽  
Barbara Gardella ◽  
Silvia Bariselli ◽  
Alessandro Alfei ◽  
Enrico Silini ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Umbilical Artery ◽  
Growth Restriction ◽  
Doppler Velocimetry ◽  
Umbilical Artery Doppler

The value of umbilical artery Doppler velocimetry in the antenatal surveillance of uncomplicated monochorionic twin pregnancies

2008 ◽  
Vol 31 (6) ◽  
pp. 662-668 ◽  
Author(s):  
K. E. A. Hack ◽  
J. J. Kaandorp ◽  
J. B. Derks ◽  
S. G. Elias ◽  
L. Pistorius ◽  
...  
Keyword(s):  
Umbilical Artery ◽  
Doppler Velocimetry ◽  
Monochorionic Twin ◽  
Umbilical Artery Doppler ◽  
Twin Pregnancies
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