How do local anesthetics compare with placebo or no treatment for pain relief in women undergoing outpatient hysteroscopy?

2018 ◽  
Keyword(s):  
Pain Relief ◽  
Local Anesthetics ◽  
Outpatient Hysteroscopy

scholarly journals Patient-controlled epidural analgesia for labor – a step forward in Ukrainian obstetrics

Pain medicine ◽  
2019 ◽  
Vol 4 (3) ◽  
pp. 67-70
Author(s):  
Yevhenii Grizhimalsky ◽  
Andrii Harha
Keyword(s):  
Patient Satisfaction ◽  
Pain Relief ◽  
Epidural Analgesia ◽  
Local Anesthetics ◽  
Gold Standard ◽  
Severe Pain ◽  
Labour Pain ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Labour pain is recognized by some women as the most severe pain that they have ever felt in their life. Epidural analgesia is an effective method of pain relief in labour and is considered as the gold standard of analgesia for delivery. Traditionally, epidural analgesia in Ukraine is performed without the ability for the patient to control the process of anesthesia. The authors became interested in the delivery of local anesthetics by patient­controlled epidural analgesia instead of the traditional physician methods. In randomized controlled studies there is an evidence that the PCEA method tends to improve the quality of pain relief and increase the patient satisfaction.

Local Anesthetics for Neuraxial and Regional Techniques

2018 ◽  
Author(s):  
Michael J Schontz ◽  
Krystina Geiger
Keyword(s):  
Pain Relief ◽  
Adverse Effects ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Lipid Emulsion ◽  
Systemic Toxicity ◽  
Duration Of Action ◽  
Liposomal Bupivacaine ◽  
Provide Pain Relief ◽  
Local Anesthetic Systemic Toxicity

Local anesthetics are used with neuraxial and regional techniques to provide pain relief, most commonly postoperatively. Each agent is a sodium-channel blocker, although each agent differs in onset of action, potency, duration of action, and safety profile. Chemical structure and lipophilicity are the main determinants of these characteristics. The agents may be used alone or in combination with an additive which alters the local anesthetic’s properties . Clinically, local anesthetics provide pain relief in a multimodal approach. This reduces opiate consumption, opiate-related adverse effects, and length of stay. Additional benefits when using neuraxial techniques include decreases in mortality, venous thromboembolism, myocardial infarction, pneumonia, respiratory depression, and duration of ileus. Although there are many adverse effects, the most serious include neurologic and cardiovascular. Seizures and cardiac arrest may result from local anesthetic systemic toxicity when systemic levels are elevated or the patient is predisposed. Dose adjustment, removal, or reversal of the agent may be clinically indicated. Lipid emulsion therapy is a reversal agent which acts as a sequestering vehicle for the local anesthetic. Liposomal bupivacaine, the newest formulation of local anesthetic, may provide an increased duration of action compared with standard formulations, although more evidence is needed. This review contains 5 figures, 5 tables, and 59 references. Keywords: amide, ester, epidural, local anesthetic, local anesthetic systemic toxicity, lipid emulsion therapy, liposomal bupivacaine, peripheral nerve block

Evaluation and ranking of different interventions for pain relief during outpatient hysteroscopy: A systematic review and network meta‐analysis

2020 ◽  
Vol 46 (6) ◽  
pp. 807-827 ◽  
Author(s):  
Nevein K. Ghamry ◽  
Ahmed Samy ◽  
Ahmed M. Abdelhakim ◽  
Ahmed Elgebaly ◽  
Safaa Ibrahim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pain Relief ◽  
Meta Analysis ◽  
Outpatient Hysteroscopy

scholarly journals Pain relief for outpatient hysteroscopy

2017 ◽  
Author(s):  
Gaity Ahmad ◽  
Sushant Saluja ◽  
Helena O'Flynn ◽  
Alessandra Sorrentino ◽  
Daniel Leach ◽  
...  
Keyword(s):  
Pain Relief ◽  
Outpatient Hysteroscopy

scholarly journals Three Studies Evaluating the Potential for Lidocaine, Bupivacaine or Procaine to Reduce Pain-Related Behaviors following Ring Castration and/or Tail Docking in Lambs

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3583
Author(s):  
Alison Small ◽  
Manon Fetiveau ◽  
Robin Smith ◽  
Ian Colditz
Keyword(s):  
Pain Relief ◽  
Local Anesthesia ◽  
Acute Pain ◽  
Local Anesthetics ◽  
Behavioral Responses ◽  
Pain Behavior ◽  
Duration Of Action ◽  
Duration Of Effect ◽  
Post Procedure ◽  
Tail Docking

The use of local anesthesia at the time of ring castration and tail docking can improve lamb welfare. However, few local anesthetics are registered for sheep, and data on their duration of effect is limited. Three studies were conducted to evaluate the efficacy of procaine (P), lidocaine (L), and bupivacaine (B) in terms of observed alleviation of behavioral responses to castration and/or tail docking in 10-min blocks in the first 60 min post-treatment. In each study, comparisons were made between two groups of lambs castrated and/or tail docked with rubber rings and either receiving the agent using the NUMNUTS® instrument (N) or receiving no anesthetic agent (RR). Acute pain behavior was lower in NL (n = 28) than RRL (n = 15) males in the first 10 min post-procedure (p < 0.05); lower in NB (n = 16) than RRB (n = 16) males in periods 10–20 min (0.05 < p < 0.01), 20–30 min (p < 0.05) and 40–50 min (0.05 < p < 0.01); lower in NB (n = 16) than RRB (n = 16) females between 20 and 40 min post-procedure (0.05 < p < 0.01); lower in NP (n = 8) than RRP (n = 7) males in period 10–20 min (0.05 < p < 0.01), and lower in NP (n = 9) than RRP (n = 9) females in periods 0–10 min (0.05 < p < 0.01), and 10–40 min (p < 0.05). Benefits were modest, and the effects of procaine appear to last longer than lidocaine, while bupivacaine is slower to take effect than either procaine or lidocaine but may provide longer-lasting pain relief. The duration of action of local anesthetics is short in sheep, and detailed behavioral evaluations are required in the first hour post-procedure to establish efficacy.

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