What evidence from randomized controlled trials (RCTs) indicates harms of erythropoiesis-stimulating agents (ESAs) in critically ill people?

2018 ◽  
Keyword(s):  
Randomized Controlled Trials ◽  
Critically Ill ◽  
Controlled Trials ◽  
Erythropoiesis Stimulating Agents ◽  
Randomized Controlled

Rotational Bed Therapy to Prevent and Treat Respiratory Complications: A Review and Meta-Analysis

2007 ◽  
Vol 16 (1) ◽  
pp. 50-61 ◽  
Author(s):  
David R. Goldhill ◽  
Michael Imhoff ◽  
Barbara McLean ◽  
Carl Waldmann
Keyword(s):  
Mechanical Ventilation ◽  
Randomized Controlled Trials ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Meta Analysis ◽  
Convincing Evidence ◽  
Controlled Trials ◽  
Respiratory Complications ◽  
Randomized Controlled ◽  
Meta Analyses

• Background Immobility is associated with complications involving many body systems. • Objective To review the effect of rotational therapy (use of therapeutic surfaces that turn on their longitudinal axes) on prevention and/or treatment of respiratory complications in critically ill patients. • Methods Published articles evaluating prophylaxis and/or treatment were reviewed. Prospective randomized controlled trials were assessed for quality and included in meta-analyses. • Results A literature search yielded 15 nonrandomized, uncontrolled, or retrospective studies. Twenty prospective randomized controlled trials on rotational therapy were published between 1987 and 2004. Various types of beds were studied, but few details on the rotational parameters were reported. The usual control was manual turning of patients by nurses every 2 hours. One animal investigation and 12 clinical trials addressed the effectiveness of rotational therapy in preventing respiratory complications. Significant benefits were reported in the animal study and 4 of the trials. Significant benefits to patients were reported in 2 of another 4 studies focused on treatment of established complications. Researchers have examined the effects of rotational therapy on mucus transport, intrapulmonary shunt, hemodynamic effects, urine output, and intracranial pressure. Little convincing evidence is available, however, on the most effective rotation parameters (eg, degree, pause time, and amount of time per day). Meta-analysis suggests that rotational therapy decreases the incidence of pneumonia but has no effect on duration of mechanical ventilation, number of days in intensive care, or hospital mortality. • Conclusions Rotational therapy may be useful for preventing and treating respiratory complications in selected critically ill patients receiving mechanical ventilation.

scholarly journals The effect of glutamine therapy on outcomes in critically ill patients: a meta-analysis of randomized controlled trials

Critical Care ◽  
2014 ◽  
Vol 18 (1) ◽  
pp. R8 ◽  
Author(s):  
Qi-Hong Chen ◽  
Yi Yang ◽  
Hong-Li He ◽  
Jian-Feng Xie ◽  
Shi-Xia Cai ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled

Effect of Stress Ulcer Prophylaxis on Outcomes in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A345
Author(s):  
Diwas Shahi ◽  
Ajai Rajabalan ◽  
Jonathan Barrera-Calix ◽  
Sunil Paudel ◽  
Tamer Said Ahmed ◽  
...  
Keyword(s):  
Randomized Controlled Trials ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Stress Ulcer ◽  
Meta Analysis ◽  
Stress Ulcer Prophylaxis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Ulcer Prophylaxis
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