What are the effects of topical antibiotics for preventing surgical site infection in surgical wounds healing by primary intention?

2017 ◽  
Keyword(s):  
Surgical Site Infection ◽  
Site Infection ◽  
Topical Antibiotics ◽  
Surgical Wounds

Surgical Site Infection Rate after Hemilaminectomy and Laminectomy in Dogs without Perioperative Antibiotic Therapy

2018 ◽  
Vol 31 (03) ◽  
pp. 202-213 ◽  
Author(s):  
Hugo Schmökel ◽  
Barbara Dyall
Keyword(s):  
Surgical Site Infection ◽  
Infection Rate ◽  
Medical Records ◽  
Bacterial Resistance ◽  
Site Infection ◽  
Surgical Wounds ◽  
Superficial Wound ◽  
Single Centre Study ◽  
Perioperative Antibiotics ◽  
Low Incidence

Objective The aim of this study was to retrospectively review the surgical site infection (SSI) rate in dogs undergoing laminectomies without perioperative antibiotics, and compare those data with the expected infection rate for clean surgical wounds in dogs undergoing similar procedures. Methods This was a retrospective single-centre study composed of dogs that underwent hemilaminectomies or laminectomies for thoracolumbar disc herniation or lumbosacral disease during a 2-year period (during 2015 and 2016). All incisional complications within 30 days were recorded and divided into superficial, deep or organ/space infections. Those dogs that received perioperative or postoperative antibiotics due to non-related comorbidities and those with incomplete medical records during the study period were excluded. Results Of 221 consecutive hemilaminectomy and laminectomy procedures, 154 were included in this research study. One superficial wound infection was recorded and treated with antimicrobials. Overall, the SSI rate was 0.6%, while the expected SSI rate in clean operative wounds in dogs and cats is 2.0 to 4.8%. The SSI rate in human spinal surgery is 0.7 to 4.3%. Clinical Significance Considering the low incidence of SSI in our study group, the routine use of perioperative antibiotic prophylaxis in dogs undergoing laminectomy procedures should be reconsidered to help address the global problem of bacterial resistance.

scholarly journals Bluebelle pilot randomised controlled trial of three wound dressing strategies to reduce surgical site infection in primary surgical wounds

BMJ Open ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. e030615 ◽  
Author(s):  
Jane Blazeby
Keyword(s):  
Randomised Controlled Trial ◽  
Surgical Site Infection ◽  
Wound Closure ◽  
Controlled Trial ◽  
Response Rates ◽  
Secondary Outcome ◽  
Site Infection ◽  
Main Trial ◽  
Surgical Wounds ◽  
Randomised Controlled

ObjectiveSurgical site infection (SSI) affects up to 25% of primary surgical wounds. Dressing strategies may influence SSI risk. The Bluebelle study assessed the feasibility of a multicentre randomised controlled trial (RCT) to evaluate the effectiveness and cost-effectiveness of different dressing strategies to reduce SSI in primary surgical wounds.DesignA pilot, factorial RCT.SettingFive UK hospitals.ParticipantsAdults undergoing abdominal surgery with a primary surgical wound.InterventionsParticipants were randomised to ‘simple dressing’, ‘glue-as-a-dressing’ or ‘no dressing’, and to the time at which the treatment allocation was disclosed to the surgeon (disclosure time, before or after wound closure).Primary and secondary outcome measuresFeasibility outcomes focused on recruitment, adherence to randomised allocations, reference assessment of SSI and response rates to participant-completed and observer-completed questionnaires to assess SSI (proposed primary outcome for main trial), wound experience and symptoms, and quality of life (EQ-5D-5L).ResultsBetween March and November 2016, 1115 patients were screened; 699 (73.4%) were eligible and approached, 415 (59.4%) consented and 394 (35.3%) were randomised (simple dressing=133, glue=129 and ‘no dressing’=132). Non-adherence to dressing allocation was 2% (3/133), 6% (8/129) and 15% (20/132), respectively. Adherence to disclosure time was 99% and 86% before and after wound closure, respectively. The overall rate of SSI (reference assessment) was 18.1% (51/281). Response rates to the Wound Healing Questionnaire and other questionnaires ranged from >90% at 4 days to 68% at 4–8 weeks.ConclusionsA definitive RCT of dressing strategies including ‘no dressing’ is feasible. Further work is needed to optimise questionnaire response rates.Trial registration number49328913; Pre-results.

scholarly journals The role of topical antibiotics used as prophylaxis in surgical site infection prevention

2011 ◽  
Vol 66 (4) ◽  
pp. 693-701 ◽  
Author(s):  
S. M. McHugh ◽  
C. J. Collins ◽  
M. A. Corrigan ◽  
A. D. K. Hill ◽  
H. Humphreys
Keyword(s):  
Surgical Site Infection ◽  
Infection Prevention ◽  
Site Infection ◽  
Topical Antibiotics

Effect of Antimicrobial Prophylaxis on the Incidence of Infections in Clean Surgical Wounds in Hospitals Undergoing Renovation

2006 ◽  
Vol 27 (12) ◽  
pp. 1372-1376 ◽  
Author(s):  
Osvaldo Iribarren ◽  
Miguel Araujo
Keyword(s):  
Relative Risk ◽  
Confidence Interval ◽  
Surgical Site Infection ◽  
Antimicrobial Prophylaxis ◽  
Control Group ◽  
Site Infection ◽  
Double Blind ◽  
Prophylaxis Group ◽  
Surgical Wounds ◽  
American Society

Objective. To measure the effect of cephazolin prophylaxis on the rate of surgical site infection among patients with clean surgical wounds, categorized by risk group, in a hospital undergoing renovation. Design. Randomized, double-blind clinical trial. Setting. Saint Paul General Hospital, Coquimbo, Chile, during a period when it was undergoing significant interior remodeling. Patients. General surgery patients who received antibiotic prophylaxis before clean wound surgery between March 2003 and May 2004 and a matched control group of patients who did not receive such prophylaxis. Results. A total of 303 patients participated in the study. The rate of infection among patients with an American Society of Anesthesiologists (ASA) classification of 1 in the prophylaxis group was 7.3%, whereas among ASA 1 patients in a no-prophylaxis control group it was 10.3% (P = .40). In the prophylaxis group, the ASA 2 and ASA 3 patients combined had an infection rate of 10.5%, whereas in the no-prophylaxis group these patients had a rate of 30.0% (relative risk, 0.33 [95% confidence interval, 0.58-0.96]; P = .03). Both the ASA 2 and ASA 3 patients were protected from infection by prophylaxis; these patients had 1.7 and 2.2 times, respectively, more risk of developing a surgical site infection than did ASA 1 patients after a clean surgical procedure, but the ASA 2 and ASA 3 patients who did not receive prophylaxis had 4.3 and 4.8 times, respectively, greater risk of infection (relative risk, 0.91 [95% confidence interval, 0.83-0.99]; P = .02). Prophylaxis significantly reduced the rate of infection in the ASA 2 and ASA 3 groups. Conclusions. We recommend the use of antimicrobial prophylaxis with cephalosporins in ASA 2 and ASA 3 patients undergoing clean wound surgery during a period when significant renovations are being performed in the hospital.

scholarly journals Operative site irrigation with povidone-iodine solution in spinal surgery for surgical site infection prevention: Can it be used safety?

2020 ◽  
Vol 24 (3) ◽  
Author(s):  
Reza Akhavan Sigari ◽  
Hesam Abdolhoseinpour
Keyword(s):  
Wound Healing ◽  
Surgical Site Infection ◽  
Spinal Surgery ◽  
Infection Prevention ◽  
Povidone Iodine ◽  
Site Infection ◽  
Efficacy And Safety ◽  
Iodine Solution ◽  
Surgical Wounds ◽  
Povidone Iodine Solution

Povidone-iodine (PVI) is an effective disinfection solution for surgical wounds. However, there is some reports of its adverse effects on wound healing and bone reunion. Here, we evaluate the efficacy and safety of PVI irrigation in the prevention of surgical site infection in spinal surgery.

scholarly journals Topical antibiotics for preventing surgical site infection in wounds healing by primary intention

2016 ◽  
Author(s):  
Clare F Heal ◽  
Jennifer L Banks ◽  
Phoebe D Lepper ◽  
Evangelos Kontopantelis ◽  
Mieke L van Driel
Keyword(s):  
Surgical Site Infection ◽  
Site Infection ◽  
Topical Antibiotics
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