Monoamine oxidase A alleles in violent offenders with antisocial personality disorder: High activity associated with proactive aggression

2014 ◽  
Vol 24 (5) ◽  
pp. 368-372 ◽  
Author(s):  
Nathan J. Kolla ◽  
Stephen Attard ◽  
Gavin Craig ◽  
Nigel Blackwood ◽  
Sheilagh Hodgins
Keyword(s):  
Personality Disorder ◽  
Monoamine Oxidase ◽  
High Activity ◽  
Antisocial Personality Disorder ◽  
Violent Offenders ◽  
Proactive Aggression ◽  
Monoamine Oxidase A ◽  
Antisocial Personality

scholarly journals Monoamine oxidase a gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder

2015 ◽  
Vol 206 (3) ◽  
pp. 216-222 ◽  
Author(s):  
D. Checknita ◽  
G. Maussion ◽  
B. Labonté ◽  
S. Comai ◽  
R. E. Tremblay ◽  
...  
Keyword(s):  
Gene Expression ◽  
Personality Disorder ◽  
Monoamine Oxidase ◽  
Antisocial Personality Disorder ◽  
Promoter Methylation ◽  
Monoamine Oxidase A ◽  
Antisocial Personality ◽  
Impulsive Aggression ◽  
Increased Risk

BackgroundAntisocial personality disorder (ASPD) is characterised by elevated impulsive aggression and increased risk for criminal behaviour and incarceration. Deficient activity of the monoamine oxidase A (MAOA) gene is suggested to contribute to serotonergic system dysregulation strongly associated with impulsive aggression and antisocial criminality.AimsTo elucidate the role of epigenetic processes in altered MAOA expression and serotonin regulation in a population of incarcerated offenders with ASPD compared with a healthy non-incarcerated control population.MethodParticipants were 86 incarcerated participants with ASPD and 73 healthy controls. MAOA promoter methylation was compared between case and control groups. We explored the functional impact of MAOA promoter methylation on gene expression in vitro and blood 5-HT levels in a subset of the case group.ResultsResults suggest that MAOA promoter hypermethylation is associated with ASPD and may contribute to downregulation of MAOA gene expression, as indicated by functional assays in vitro, and regression analysis with whole-blood serotonin levels in offenders with ASPD.ConclusionsThese results are consistent with prior literature suggesting MAOA and serotonergic dysregulation in antisocial populations. Our results offer the first evidence suggesting epigenetic mechanisms may contribute to MAOA dysregulation in antisocial offenders.

scholarly journals Cool and Hot Executive Function Impairments in Violent Offenders with Antisocial Personality Disorder with and without Psychopathy

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65566 ◽  
Author(s):  
Stephane A. De Brito ◽  
Essi Viding ◽  
Veena Kumari ◽  
Nigel Blackwood ◽  
Sheilagh Hodgins
Keyword(s):  
Executive Function ◽  
Personality Disorder ◽  
Antisocial Personality Disorder ◽  
Violent Offenders ◽  
Antisocial Personality
Sign in / Sign up

Export Citation Format

Share Document