Cultured human skeletal muscle satellite cells exhibit characteristics of mesenchymal stem cells and play anti‐inflammatory roles through prostaglandin E2 and hepatocyte growth factors

2021 ◽  
Author(s):  
Seongyup Kim ◽  
Pil Young Jung ◽  
Jin Suk Lee ◽  
Soonjae Hwang ◽  
Joon Hyung Sohn ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Prostaglandin E2 ◽  
Satellite Cells ◽  
Human Skeletal Muscle ◽  
Muscle Satellite Cells ◽  
Hepatocyte Growth Factors ◽  
Hepatocyte Growth

scholarly journals Stem cells for skeletal muscle repair

2011 ◽  
Vol 366 (1575) ◽  
pp. 2297-2306 ◽  
Author(s):  
Jennifer L. Shadrach ◽  
Amy J. Wagers
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Cell Function ◽  
Therapeutic Potential ◽  
Muscle Disease ◽  
Muscle Fibres ◽  
Muscle Repair ◽  
Muscle Satellite Cells

Skeletal muscle is a highly specialized tissue composed of non-dividing, multi-nucleated muscle fibres that contract to generate force in a controlled and directed manner. Skeletal muscle is formed during embryogenesis from a subset of muscle precursor cells, which generate both differentiated muscle fibres and specialized muscle-forming stem cells known as satellite cells. Satellite cells remain associated with muscle fibres after birth and are responsible for muscle growth and repair throughout life. Failure in satellite cell function can lead to delayed, impaired or failed recovery after muscle injury, and such failures become increasingly prominent in cases of progressive muscle disease and in old age. Recent progress in the isolation of muscle satellite cells and elucidation of the cellular and molecular mediators controlling their activity indicate that these cells represent promising therapeutic targets. Such satellite cell-based therapies may involve either direct cell replacement or development of drugs that enhance endogenous muscle repair mechanisms. Here, we discuss recent breakthroughs in understanding both the cell intrinsic and extrinsic regulators that determine the formation and function of muscle satellite cells, as well as promising paths forward to realizing their full therapeutic potential.

Human skeletal muscle satellite cells: aging, oxidative stress and the mitotic clock

2002 ◽  
Vol 37 (10-11) ◽  
pp. 1229-1236 ◽  
Author(s):  
Valérie Renault ◽  
Lars-Eric Thornell ◽  
Gillian Butler-Browne ◽  
Vincent Mouly
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Satellite Cells ◽  
Human Skeletal Muscle ◽  
Muscle Satellite Cells ◽  
Skeletal Muscle Satellite Cells ◽  
Mitotic Clock

Hepatocyte growth factor activates quiescent skeletal muscle satellite cells in vitro

1995 ◽  
Vol 165 (2) ◽  
pp. 307-312 ◽  
Author(s):  
Ronald E. Allen ◽  
Shannon M. Sheehan ◽  
Richard G. Taylor ◽  
Teresa L. Kendall ◽  
Glenna M. Rice
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Satellite Cells ◽  
Muscle Satellite Cells ◽  
Skeletal Muscle Satellite Cells ◽  
Hepatocyte Growth

scholarly journals Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals

2018 ◽  
Vol 6 (12) ◽  
pp. e13739 ◽  
Author(s):  
Mladen Savikj ◽  
Maxwell A. Ruby ◽  
Emil Kostovski ◽  
Per O. Iversen ◽  
Juleen R. Zierath ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Satellite Cells ◽  
Human Skeletal Muscle ◽  
Muscle Satellite Cells ◽  
Differentiation Capacity ◽  
Skeletal Muscle Satellite Cells ◽  
Spinal Cord Injured
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