Angiotensin II modulates the murine hematopoietic stem cell (HSC) and progenitors co‐cultured with stromal S17 cells

2021 ◽  
Author(s):  
Maíra Maftoum Costa ◽  
Roberta Sessa Stilhano ◽  
Carlos Rocha Oliveira ◽  
Chistiano Marcello Vaz Barbosa ◽  
Gustavo JS Pereira ◽  
...  
Keyword(s):  
Stem Cell ◽  
Angiotensin Ii ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Murine Hematopoietic Stem Cell

scholarly journals MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation

Haematologica ◽  
2019 ◽  
Vol 104 (9) ◽  
pp. 1744-1755 ◽  
Author(s):  
Laura Crisafulli ◽  
Sharon Muggeo ◽  
Paolo Uva ◽  
Yulei Wang ◽  
Masayuki Iwasaki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Murine Hematopoietic Stem Cell ◽  
Cell Maintenance

scholarly journals Pontin is essential for murine hematopoietic stem cell survival

Haematologica ◽  
2012 ◽  
Vol 97 (9) ◽  
pp. 1291-1294 ◽  
Author(s):  
O. Bereshchenko ◽  
E. Mancini ◽  
L. Luciani ◽  
A. Gambardella ◽  
C. Riccardi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival ◽  
Murine Hematopoietic Stem Cell

scholarly journals Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158369 ◽  
Author(s):  
Alexandra Rundberg Nilsson ◽  
Shamit Soneji ◽  
Sofia Adolfsson ◽  
David Bryder ◽  
Cornelis Jan Pronk
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Aging ◽  
Functional Impairments ◽  
Hematopoietic Stem ◽  
Stem Cell Aging ◽  
Murine Hematopoietic Stem Cell

Long-term Residual Radiation Effect in the Murine Hematopoietic Stem Cell Compartment

1985 ◽  
Vol 459 (1 Hematopoietic) ◽  
pp. 221-231 ◽  
Author(s):  
K.-H. V. WANGENHEIM ◽  
H.P, PETERSON, ◽  
G. E. HÜBNER ◽  
L. E. FEINENDEGEN
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Radiation Effect ◽  
Cell Compartment ◽  
Hematopoietic Stem ◽  
Stem Cell Compartment ◽  
Murine Hematopoietic Stem Cell

scholarly journals Functional screen identifies regulators of murine hematopoietic stem cell repopulation

2016 ◽  
Vol 213 (3) ◽  
pp. 433-449 ◽  
Author(s):  
Per Holmfeldt ◽  
Miguel Ganuza ◽  
Himangi Marathe ◽  
Bing He ◽  
Trent Hall ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Surface Receptor ◽  
The Novel ◽  
Loss Of Function ◽  
Hematopoietic Stem ◽  
Extracellular Matrix Components ◽  
Murine Hematopoietic Stem Cell ◽  
Surface Receptor ◽  
First Time

Understanding the molecular regulation of hematopoietic stem and progenitor cell (HSPC) engraftment is paramount to improving transplant outcomes. To discover novel regulators of HSPC repopulation, we transplanted >1,300 mice with shRNA-transduced HSPCs within 24 h of isolation and transduction to focus on detecting genes regulating repopulation. We identified 17 regulators of HSPC repopulation: Arhgef5, Armcx1, Cadps2, Crispld1, Emcn, Foxa3, Fstl1, Glis2, Gprasp2, Gpr56, Myct1, Nbea, P2ry14, Smarca2, Sox4, Stat4, and Zfp521. Knockdown of each of these genes yielded a loss of function, except in the cases of Armcx1 and Gprasp2, whose loss enhanced hematopoietic stem cell (HSC) repopulation. The discovery of multiple genes regulating vesicular trafficking, cell surface receptor turnover, and secretion of extracellular matrix components suggests active cross talk between HSCs and the niche and that HSCs may actively condition the niche to promote engraftment. We validated that Foxa3 is required for HSC repopulating activity, as Foxa3−/− HSC fails to repopulate ablated hosts efficiently, implicating for the first time Foxa genes as regulators of HSPCs. We further show that Foxa3 likely regulates the HSC response to hematologic stress. Each gene discovered here offers a window into the novel processes that regulate stable HSPC engraftment into an ablated host.

scholarly journals Murine hematopoietic stem cell reconstitution potential is maintained by osteopontin during aging

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jin Li ◽  
Carmen Carrillo García ◽  
Tamara Riedt ◽  
Maria Brandes ◽  
Sabrina Szczepanski ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Murine Hematopoietic Stem Cell
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