LncRNA TTN‐AS1/miR‐134‐5p/PAK3 axis regulates the radiosensitivity of human large intestine cancer cells through the P21 pathway and AKT/GSK‐3β/β‐catenin pathway

2020 ◽  
Vol 44 (11) ◽  
pp. 2284-2292
Author(s):  
Zhenkui Zuo ◽  
Shuling Ji ◽  
Lulu He ◽  
Yage Zhang ◽  
Zining Peng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Large Intestine ◽  
Human Large Intestine ◽  
Gsk 3Β

scholarly journals GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 816
Author(s):  
Stephen L. Abrams ◽  
Shaw M. Akula ◽  
Akshaya K. Meher ◽  
Linda S. Steelman ◽  
Agnieszka Gizak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signal Transduction ◽  
Cancer Cells ◽  
Mitochondrial Respiration ◽  
Breast Cancer Cells ◽  
Chemotherapeutic Drugs ◽  
Pancreatic Cancers ◽  
Signal Transduction Inhibitors ◽  
Gsk 3Β ◽  
Mcf 7

Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link between KRas and GSK-3. To further elucidate the roles of GSK-3β in drug-resistance, we transfected KRas-dependent MIA-PaCa-2 pancreatic cells with wild-type (WT) and kinase-dead (KD) forms of GSK-3β. Transfection of MIA-PaCa-2 cells with WT-GSK-3β increased their resistance to various chemotherapeutic drugs and certain small molecule inhibitors. Transfection of cells with KD-GSK-3β often increased therapeutic sensitivity. An exception was observed with cells transfected with WT-GSK-3β and sensitivity to the BCL2/BCLXL ABT737 inhibitor. WT-GSK-3β reduced glycolytic capacity of the cells but did not affect the basal glycolysis and mitochondrial respiration. KD-GSK-3β decreased both basal glycolysis and glycolytic capacity and reduced mitochondrial respiration in MIA-PaCa-2 cells. As a comparison, the effects of GSK-3 on MCF-7 breast cancer cells, which have mutant PIK3CA, were examined. KD-GSK-3β increased the resistance of MCF-7 cells to chemotherapeutic drugs and certain signal transduction inhibitors. Thus, altering the levels of GSK-3β can have dramatic effects on sensitivity to drugs and signal transduction inhibitors which may be influenced by the background of the tumor.

Helicobacter pyloriinduces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3β in human gastric cancer cells

2016 ◽  
Vol 55 (12) ◽  
pp. 2236-2246 ◽  
Author(s):  
Hoang-Kieu-Chi Ngo ◽  
Hee Geum Lee ◽  
Juan-Yu Piao ◽  
Xiancai Zhong ◽  
Ha-Na Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Snail Expression ◽  
Gsk 3Β

1090 The Aurora Kinase a Regulates GSK-3β/β-Catenin/Tcf Complex Signaling in Gastric Cancer Cells

2009 ◽  
Vol 136 (5) ◽  
pp. A-168
Author(s):  
Abbes Belkhiri ◽  
Altaf A. Dar ◽  
Mohammed Soutto ◽  
M. Blanca Piazuelo ◽  
Pelayo Correa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Aurora Kinase ◽  
Gastric Cancer Cells ◽  
Aurora Kinase A ◽  
Gsk 3Β ◽  
Complex Signaling ◽  
Kinase A

Sulphate-reducing bacteria and the human large intestine

2009 ◽  
pp. 503-522 ◽  
Author(s):  
George T. Macfarlane ◽  
John H. Cummings ◽  
Sandra Macfarlane
Keyword(s):  
Large Intestine ◽  
Sulphate Reducing Bacteria ◽  
Human Large Intestine ◽  
Reducing Bacteria
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