Fibroblast growth factor‐2 and interleukin‐4 synergistically induce eotaxin‐1 expression in adipose tissue‐derived stromal cells

2020 ◽  
Vol 44 (5) ◽  
pp. 1124-1132
Author(s):  
Hidemi Hattori ◽  
Masayuki Ishihara
Keyword(s):  
Adipose Tissue ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Stromal Cells ◽  
Interleukin 4 ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth

Adipose Tissue Engineering Based on the Controlled Release of Fibroblast Growth Factor-2 in a Collagen Matrix

2006 ◽  
Vol 12 (11) ◽  
pp. 3035-3043 ◽  
Author(s):  
Aditya V. Vashi ◽  
Keren M. Abberton ◽  
Gregory P. Thomas ◽  
Wayne A. Morrison ◽  
Andrea J. O'Connor ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Adipose Tissue ◽  
Controlled Release ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Collagen Matrix ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Adipose Tissue Engineering

scholarly journals The effects of combined administration of human umbilical cord-derived multipotent mesenchymal stromal cells and melatonin or fibroblast growth factor-2 to aged mice with a toxic cuprizone model of demyelination

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
I. Labunets ◽  
◽  
N. Utko ◽  
O. Toporova ◽  
Ia. Pokholenko ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Umbilical Cord ◽  
Stromal Cells ◽  
Behavioral Response ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Aged Mice ◽  
The Brain

The effect of transplantation of umbilical cord-derived multipotent mesenchymal stromal cells (UC-MMSCs) to patients with demyelinating diseases depends on the age of the recipient and can change under the influence of hormones or growth factors. Purpose. To investigate the effect of exogenous melatonin and recombinant human fibroblast growth factor-2 (rhFGF-2) on the effects of UC-MMSCs transplanted into aged mice with an experimental model of multiple sclerosis. Material and methods. 129/Sv mice, 15-17 months old, received the neurotoxin cuprizone with food for 3 weeks. From the 10th day of the cuprizone diet, 5•105 UC-MMSCs were injected intravenously. From the 11th day they received melatonin at 600 p.m. or rhFGF-2. The behavioral parameters were evaluated in the open field test and rotarod test. In the brain, the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and the level of malondialdehyde (MDA) were assessed. Results. Cuprizone intake reduces the behavioral response in mice compared to the intact group. The transplantation of UC-MMSCs increases the number of rearings and muscle tone in mice. Melatonin injections enhance the effects of cells on these parameters, as well as increase the motor and emotional activity of animals. The injection of rhFGF-2 preserves the effect of cells on behavioral response and increases locomotor activity in mice. After the injection of UC-MMSCs with melatonin or rhFGF-2, the content of MDA in the brain decreases and the activity of antioxidant enzymes increases, this is more significant under the influence of melatonin. Conclusion. Exogenous melatonin and rhFGF-2 improve the effects of transplanted UC-MMSCs on behavioral responses and brain antioxidant defenses in aged mice with cuprizone diet. At the same time, the positive effect of the combination of cells with melatonin is more pronounced.

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