Insulin‐like growth factor‐I promotes hepatic differentiation of human adipose tissue‐derived stem cells

2019 ◽  
Vol 43 (5) ◽  
pp. 476-485 ◽  
Author(s):  
Zahra Shabani Azandaryani ◽  
Nahid Davoodian ◽  
Afshin Samiei ◽  
Sahere Rouzbehan
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Growth Factor ◽  
Human Adipose Tissue ◽  
Insulin Like Growth Factor ◽  
Hepatic Differentiation ◽  
Factor I ◽  
Growth Factor I

scholarly journals Brain Insulin-Like Growth Factor-I Directs the Transition from Stem Cells to Mature Neurons During Postnatal/Adult Hippocampal Neurogenesis

Stem Cells ◽  
2016 ◽  
Vol 34 (8) ◽  
pp. 2194-2209 ◽  
Author(s):  
Vanesa Nieto-Estévez ◽  
Carlos O. Oueslati-Morales ◽  
Lingling Li ◽  
James Pickel ◽  
Aixa V. Morales ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Brain Insulin ◽  
Mature Neurons ◽  
Growth Factor I

scholarly journals Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease

2016 ◽  
Vol 5 (3) ◽  
pp. 379-391 ◽  
Author(s):  
Lisa M. McGinley ◽  
Erika Sims ◽  
J. Simon Lunn ◽  
Osama N. Kashlan ◽  
Kevin S. Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Cellular Therapy ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Insulin-like growth factor I mediates high-fat diet-induced adipogenesis in Osborne-Mendel rats

2000 ◽  
Vol 278 (3) ◽  
pp. R654-R662 ◽  
Author(s):  
Brenda G. Marques ◽  
Dorothy B. Hausman ◽  
Amanda M. Latimer ◽  
Krystyna M. Kras ◽  
Barbara Mullen Grossman ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Growth Factor ◽  
Cell Number ◽  
Insulin Like Growth Factor ◽  
High Fat ◽  
Fat Cell ◽  
Immunomagnetic Bead ◽  
Factor I ◽  
Growth Factor I ◽  
Paracrine Growth Factor

To determine if high-fat (HF) diet-induced changes in adipose tissue cellularity are associated with the presence of paracrine growth factor(s) that alter preadipocyte proliferation, Osborne-Mendel rats were fed either a HF (76% energy) or a low-fat (LF, 12% energy) diet for 85 days. HF-fed rats had greater ( P < 0.05) fat pad size, total fat cell number, number of small (30–70 μm) and large (80–140 μm) adipocytes, and percentage of 100- to 140-μm adipocytes compared with LF-fed rats. Preadipocytes in primary cell culture treated with inguinal adipose tissue conditioned medium (ATCM) prepared from HF-fed rats had greater ( P < 0.05) proliferation compared with cultures treated with ATCM from LF-fed rats. Proliferative capacity of ATCM prepared from HF-fed rats was attenuated after the stripping of the medium of insulin-like growth factor I using an immunomagnetic bead separation system. These data are consistent with the concept that insulin-like growth factor I is involved in the paracrine regulation of adipogenesis.

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