scholarly journals The role of TGF-β1 during skeletal muscle regeneration

2017 ◽  
Vol 41 (7) ◽  
pp. 706-715 ◽  
Author(s):  
Kamila Delaney ◽  
Paulina Kasprzycka ◽  
Maria Anna Ciemerych ◽  
Malgorzata Zimowska
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Tgf Β1

scholarly journals The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration

2019 ◽  
Vol 30 (12) ◽  
pp. 1553-1598 ◽  
Author(s):  
Francesca De Santa ◽  
Laura Vitiello ◽  
Alessio Torcinaro ◽  
Elisabetta Ferraro
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Macrophage Polarization ◽  
Skeletal Muscle Regeneration ◽  
Metabolic Remodeling

The Potential Role of Insulin-Like Growth Factors in Skeletal Muscle Regeneration

1996 ◽  
Vol 21 (4) ◽  
pp. 236-250 ◽  
Author(s):  
Jamie MacGregor ◽  
Wade S. Parkhouse
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Growth Factors ◽  
Muscle Regeneration ◽  
Potential Role ◽  
Tissue Growth ◽  
Skeletal Muscle Regeneration ◽  
Tissue Type ◽  
Insulin Like Growth Factors

The role of the insulin-like growth factors I and II (IGF-I and IGF-II), previously known as the somatomedins, in general growth and development of various tissues has been known for many years. Thought of exclusively as endocrine factors produced by the liver, and under the control of growth hormone, the somatomedins were known as the intermediaries by which growth hormone exerted its cellular effects during tissue growth and maturation. Eventually it was discovered that virtually every tissue type is capable of autocrine production of the IGFs, and their involvement in skeletal muscle tissue repair and regeneration became apparent. Recent advances in technology have allowed the characterisation of many of the different growth factors believed to play a role in muscle regeneration, and experimental manipulations of cells in culture have provided insight into the effects of the various growth factors on the myoblast. This paper explores the potential role of the IGFs in skeletal muscle regeneration. A critical role of IGF-II in terminal differentiation of proliferating muscle precurser cells following injury is proposed. Key words: growth factors, myogenesis, skeletal muscle regeneration

scholarly journals Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner

2021 ◽  
pp. 1-23
Author(s):  
Theret Marine ◽  
Saclier Marielle ◽  
Messina Graziella ◽  
Rossi M.V. Fabio
Keyword(s):  
Skeletal Muscle ◽  
Endothelial Cells ◽  
Muscle Regeneration ◽  
Genetic Diseases ◽  
Fatty Infiltration ◽  
Skeletal Muscle Regeneration ◽  
Muscular Dystrophies ◽  
Pathogenic Role ◽  
Muscle Remodeling

While skeletal muscle remodeling happens throughout life, diseases that result in its dysfunction are accountable for many deaths. Indeed, skeletal muscle is exceptionally capable to respond to stimuli modifying its homeostasis, such as in atrophy, hypertrophy, regeneration and repair. In particular conditions such as genetic diseases (muscular dystrophies), skeletal muscle’s capacity to remodel is strongly affected and undergoes continuous cycles of chronic damage. This induces scarring, fatty infiltration, as well as loss of contractibility and of the ability to generate force. In this context, inflammation, primarily mediated by macrophages, plays a central pathogenic role. Macrophages contribute as the primary regulators of inflammation during skeletal muscle regeneration, affecting tissue-resident cells such as myogenic cells and endothelial cells, but also fibro-adipogenic progenitors, which are the main source of the fibro fatty scar. During skeletal muscle regeneration their function is tightly orchestrated, while in dystrophies their fate is strongly disturbed, resulting in chronic inflammation. In this review, we will discuss the latest findings on the role of macrophages in skeletal muscle diseases, and how they are regulated.

The Role of Macrophages in Skeletal Muscle Regeneration with Particular Reference to Chemotaxis

1993 ◽  
Vol 207 (2) ◽  
pp. 321-331 ◽  
Author(s):  
T.A. Robertson ◽  
M.A.L. Maley ◽  
M.D. Grounds ◽  
J.M. Papadimitriou
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

scholarly journals Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation

2013 ◽  
Vol 22 (16) ◽  
pp. 2298-2314 ◽  
Author(s):  
Alexander Birbrair ◽  
Tan Zhang ◽  
Zhong-Min Wang ◽  
Maria Laura Messi ◽  
Grigori N. Enikolopov ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Fat Accumulation

A possible role of MAP-1 in skeletal muscle regeneration

Immunobiology ◽  
2012 ◽  
Vol 217 (11) ◽  
pp. 1130
Author(s):  
Lea Munthe-Fog ◽  
P. Schjerling ◽  
Mikkel-Ole Skjoedt ◽  
T. Krag ◽  
H.O. Madsen ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration

The role of leukemia inhibitory factor in skeletal muscle regeneration

1997 ◽  
Vol 20 (7) ◽  
pp. 815-822 ◽  
Author(s):  
John B. Kurek ◽  
John J. Bower ◽  
Margarita Romanella ◽  
Frank Koentgen ◽  
Mark Murphy ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Regeneration ◽  
Leukemia Inhibitory Factor ◽  
Inhibitory Factor ◽  
Skeletal Muscle Regeneration

Role of Ascorbic Acid in Skeletal Muscle Regeneration

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Tomofumi Yatsu ◽  
Yuka Takino ◽  
Akihito Ishigami
Keyword(s):  
Skeletal Muscle ◽  
Ascorbic Acid ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration
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