Erythropoietin-enhanced endothelial progenitor cell recruitment in peripheral blood and renal vessels during experimental acute kidney injury in rats

2016 ◽  
Vol 40 (3) ◽  
pp. 298-307 ◽  
Author(s):  
Figen Cakiroglu ◽  
Sora Maria Enders-Comberg ◽  
Horst Pagel ◽  
Jürgen Rohwedel ◽  
Hendrik Lehnert ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Endothelial Progenitor Cell ◽  
Peripheral Blood ◽  
Progenitor Cell ◽  
Kidney Injury ◽  
Endothelial Progenitor ◽  
Cell Recruitment ◽  
Renal Vessels

scholarly journals Does erythropoietin therapy affect circulating endothelial cells in hemodialysis patients?

2020 ◽  
pp. 29-37
Author(s):  
T. Bulduk ◽  
A. U. Yalcin ◽  
O. M. Akay ◽  
S. G. Ozkurt ◽  
H. U. Teke ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Endothelial Progenitor Cell ◽  
Peripheral Blood ◽  
Progenitor Cell ◽  
Hemodialysis Patients ◽  
Circulating Endothelial Cells ◽  
Control Group ◽  
Endothelial Progenitor

Anemia is a common complication of chronic kidney disease (CKD). The most common cause of anemia in CKD is erythropoietin deficiency; and the most important cause of mortality in CKD patients is atherosclerotic vascular complications which are associated with endothelial damage. One of the methods evaluating vascular integrity is the cytometric measurement of circulating endothelial cells and endothelial progenitor cells in peripheral blood. The study aimed to investigate the effects of erythropoietin therapy on endothelial dysfunction by evaluating circulating endothelial cells and endothelial progenitor cells in peripheral blood using the technique of flow cytometry. Methods. A total of 55 hemodialysis patients were evaluated in three groups; those having erythropoietin therapy for at least last 3 months (n = 20) / not having erythropoietin for at least the last 3 months (n = 20) and the patients who started erythropoietin treatment during the study (n = 5). The control group consisted of 20 people. Blood values of the 3rd Group were investigated three times as baseline, 2nd week and 8th week CD34 +, CD105 + cells were evaluated as activated circulating endothelial cells; CD133 +, CD146 + cells were evaluated as activated endothelial progenitor cells. Results. There was no difference between the patients and healthy individuals in terms of circulating endothelial cells and endothelial progenitor cells. In the third group, no differences were observed in circulating endothelial cells / endothelial progenitor cell levels at baseline / 2nd and 8th weeks. There was no correlation between erythropoietin and circulating endothelial cells / endothelial progenitor cells. Conclusion. A correlation is not available between the therapeutic doses of erythropoietin used in hemodialysis patients and circulating endothelial cells / endothelial progenitor cell levels; supratherapeutic doses could change the results.

Effects of Statins on Endothelium and Endothelial Progenitor Cell Recruitment

2004 ◽  
Vol 4 (04) ◽  
pp. 385-393 ◽  
Author(s):  
Dirk H Walter ◽  
Stefanie Dimmeler ◽  
Andreas M Zeiher
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Cell Recruitment

Endothelial progenitor cell recruitment in a microfluidic vascular model

2015 ◽  
Vol 7 (4) ◽  
pp. 045010 ◽  
Author(s):  
Daniel M Lewis ◽  
Hasan E Abaci ◽  
Yu Xu ◽  
Sharon Gerecht
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Cell Recruitment ◽  
Vascular Model

Mechanism of angiopoietin-1 mediated endothelial progenitor cell recruitment in wound healing

2004 ◽  
Vol 199 (3) ◽  
pp. 60
Author(s):  
Sundeep G. Keswani ◽  
Jignesh K. Parvadia ◽  
David Stitelman ◽  
Elliot D. Kozin ◽  
Antoneta P. Radu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Cell Recruitment ◽  
Angiopoietin 1

scholarly journals Local Delivery of VEGF and SDF Enhances Endothelial Progenitor Cell Recruitment and Resultant Recovery from Ischemia

2015 ◽  
Vol 21 (7-8) ◽  
pp. 1217-1227 ◽  
Author(s):  
Erin M. Anderson ◽  
Brian J. Kwee ◽  
Sarah A. Lewin ◽  
Theresa Raimondo ◽  
Manav Mehta ◽  
...  
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Local Delivery ◽  
Endothelial Progenitor ◽  
Cell Recruitment
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