Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress

2016 ◽  
Vol 40 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Zhen Wang ◽  
Xin Zhao ◽  
Xingguo Gong
Keyword(s):  
Reactive Oxygen Species ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Lung Adenocarcinoma ◽  
A549 Cells ◽  
Oxygen Species ◽  
Adenocarcinoma Cell Line ◽  
Adenocarcinoma Cell ◽  
Lung Adenocarcinoma Cell Line ◽  
Ros Reactive Oxygen Species

A homozygous deletion at FRA3B in a lung adenocarcinoma cell line with normal expression of the FHIT gene

1996 ◽  
Vol 91 (2) ◽  
pp. 170 ◽  
Author(s):  
Tineke G. Draaijers ◽  
Anke van den Berg ◽  
Klaas Kokl ◽  
Tineke Timmer ◽  
Anneke Y. van der Veen ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cell Line ◽  
Homozygous Deletion ◽  
Adenocarcinoma Cell Line ◽  
Fhit Gene ◽  
Adenocarcinoma Cell ◽  
Lung Adenocarcinoma Cell Line ◽  
Normal Expression

CHARACTERISATION OF PLATELET AGGREGATING MATERIAL EXTRACTED FROM HUMAN LUNG ADENOCARCINOMA CELL LINE WHICH METASTASIZED IN NUDE MICE S,C, IMPLANTATION

1987 ◽  
Author(s):  
H Inufusa ◽  
N Sagara ◽  
K Nakano ◽  
M Yasutomi
Keyword(s):  
Platelet Aggregation ◽  
Lung Adenocarcinoma ◽  
Human Lung ◽  
Human Cancer ◽  
Metastatic Potential ◽  
Adenocarcinoma Cell Line ◽  
Adenocarcinoma Cell ◽  
Lung Adenocarcinoma Cell Line ◽  
Aggregation Activity ◽  
Human Lung Adenocarcinoma Cell

It has been reported in animal experimental system that Platelet Aggregating Material (PAM) of cancer cell play important role in cancer metastasis. Many human cancer cell lines has been also studied the platelet aggregation activity of PAM. But correlation between the platelet aggregation activity and metastatic potential of human cancer cells were usually unkncwn. We established a human lung adenocarcinoma cell line KUM-LK-2 which produce spontaneous lung metastasis when cells implanted into subcutaneous of nude mice. PAM was extracted from KUM-LK-2 cells following the method of D.Mbhanty and P.Hilgard. Platelet aggregation study of PAM was performed by human Heparinized platelet rich plasma useing NIKO Hematracer PACT2D. Character of PAM were examined by physical and chemical treatment. KUM-LK-2 PAM shew 80% of platelet aggregation in maximum after 150 sec lag time, and aggregation was not found by Citrated PRP.It is concluded that PAM is high moleculer protein and contain Phospholipid and aggregation activity is concerning with ATP composition of platelet. PAM dose not contain Fibrinogen and Sialic acid, and not concern with Throrriboxan composition. This study is first case of platelet aggregation activity of PAM extracted human canoer cells which contain metastatic potential.

Sign in / Sign up

Export Citation Format

Share Document