mGlu3 receptor blockade inhibits proliferation and promotes astrocytic phenotype in glioma stem cells

2014 ◽  
Vol 38 (4) ◽  
pp. 426-434 ◽  
Author(s):  
Kun Zhou ◽  
Yechun Song ◽  
Wei Zhou ◽  
Chunqing Zhang ◽  
Haifeng Shu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioma Stem Cells ◽  
Receptor Blockade ◽  
Mglu3 Receptor

The Heterogeneity of Glioma Stem Cells

2015 ◽  
Vol 9 (2) ◽  
pp. 70-77
Author(s):  
Suojun Zhang ◽  
Feng Wan ◽  
Lin Han ◽  
Fei Ye ◽  
Dongsheng Guo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioma Stem Cells

CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway

Oncogene ◽  
2021 ◽  
Author(s):  
Kazuya Fukasawa ◽  
Takuya Kadota ◽  
Tetsuhiro Horie ◽  
Kazuya Tokumura ◽  
Ryuichi Terada ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioma Stem Cells

scholarly journals Prrx1 promotes stemness and angiogenesis via activating TGF-β/smad pathway and upregulating proangiogenic factors in glioma

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Zetao Chen ◽  
Yihong Chen ◽  
Yan Li ◽  
Weidong Lian ◽  
Kehong Zheng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Therapeutic Strategy ◽  
Critical Role ◽  
Glioma Stem Cells ◽  
Promoter Regions ◽  
Aberrant Expression ◽  
Smad Pathway ◽  
Tgf Β1

AbstractGlioma is one of the most lethal cancers with highly vascularized networks and growing evidences have identified glioma stem cells (GSCs) to account for excessive angiogenesis in glioma. Aberrant expression of paired-related homeobox1 (Prrx1) has been functionally associated with cancer stem cells including GSCs. In this study, Prrx1 was found to be markedly upregulated in glioma specimens and elevated Prrx1 expression was inversely correlated with prognosis of glioma patients. Prrx1 potentiated stemness acquisition in non-stem tumor cells (NSTCs) and stemness maintenance in GSCs, accompanied with increased expression of stemness markers such as SOX2. Prrx1 also promoted glioma angiogenesis by upregulating proangiogenic factors such as VEGF. Consistently, silencing Prrx1 markedly inhibited glioma proliferation, stemness, and angiogenesis in vivo. Using a combination of subcellular proteomics and in vitro analyses, we revealed that Prrx1 directly bound to the promoter regions of TGF-β1 gene, upregulated TGF-β1 expression, and ultimately activated the TGF-β/smad pathway. Silencing TGF-β1 mitigated the malignant behaviors induced by Prrx1. Activation of this pathway cooperates with Prrx1 to upregulate the expression of stemness-related genes and proangiogenic factors. In summary, our findings revealed that Prrx1/TGF-β/smad signal axis exerted a critical role in glioma stemness and angiogeneis. Disrupting the function of this signal axis might represent a new therapeutic strategy in glioma patients.

scholarly journals GAS5 suppresses malignancy of human glioma stem cells via a miR-196a-5p/FOXO1 feedback loop

2017 ◽  
Vol 1864 (10) ◽  
pp. 1605-1617 ◽  
Author(s):  
Xihe Zhao ◽  
Yunhui Liu ◽  
Jian Zheng ◽  
Xiaobai Liu ◽  
Jiajia Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Feedback Loop ◽  
Glioma Stem Cells ◽  
Human Glioma

scholarly journals Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression

2015 ◽  
Vol 16 (3) ◽  
pp. 219-220 ◽  
Author(s):  
Yu Shi ◽  
Yi-fang Ping ◽  
Xia Zhang ◽  
Xiu-wu Bian
Keyword(s):  
Stem Cells ◽  
Tumor Progression ◽  
Glioma Stem Cells ◽  
Hostile Takeover
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