Positioning of integrin β1, caveolin-1 and focal adhesion kinase on the adhered membrane of spreading cells

2013 ◽  
Vol 37 (12) ◽  
pp. 1276-1284 ◽  
Author(s):  
Špela Zemljič Jokhadar ◽  
Janja Majhenc ◽  
Saša Svetina ◽  
Urška Batista
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Integrin Β1 ◽  
Caveolin 1

Caveolin-1 promotes trophoblast cell invasion through the focal adhesion kinase (FAK) signalling pathway during early human placental development

2019 ◽  
Vol 31 (6) ◽  
pp. 1057 ◽  
Author(s):  
Zhihui Dai ◽  
Fei Sheng ◽  
Ningxia Sun ◽  
Yixuan Ji ◽  
Qiuying Liao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cell Invasion ◽  
Trophoblast Cell ◽  
Signalling Pathway ◽  
Placental Development ◽  
Human Trophoblast ◽  
Expression Levels ◽  
Caveolin 1

Normal implantation and placental development depend on the appropriate differentiation and invasion of trophoblast cells. Inadequate trophoblast cell invasion results in pregnancy-related disorders, which endanger both mother and fetus; however, the mechanism of early placental development has not been fully explained. In this study we conducted gene expression profile analysis using mouse placental tissues at different developmental stages (embryonic day (E)7.5, E14.5 and E19.5) using series tests of cluster (STC) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway analyses. Focal adhesion kinase (FAK) signalling pathway-related gene expression levels were verified using quantitative reverse transcription polymerase chain reaction and western blot. The results showed that caveolin-1 (Cav1) was downregulated in the placenta of unexplained spontaneous abortion subjects compared with that of induced abortion. Furthermore, by modulating CAV1 expression levels, CAV1 was shown to promote human trophoblast cell proliferation, migration and invasion by activating the FAK signalling pathway. These results indicate that CAV1 and the FAK signalling pathway are crucial for early placental development, which sheds new light on our understanding of the mechanisms of human trophoblast cell invasion and early development of the placenta.

scholarly journals The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

2021 ◽  
Vol 15 (1) ◽  
pp. 58-73
Author(s):  
Andrea A. Villanueva ◽  
Pilar Sanchez-Gomez ◽  
Ernesto Muñoz-Palma ◽  
Sofía Puvogel ◽  
Bárbara S. Casas ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Neuroblastoma Cell ◽  
Integrin Β1 ◽  
Kinase Activation ◽  
Signaling Axis

scholarly journals Down-Regulation of Integrin β1 and Focal Adhesion Kinase in Renal Glomeruli under Various Hemodynamic Conditions

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94212 ◽  
Author(s):  
Xiaoli Yuan ◽  
Wei Wang ◽  
Juan Wang ◽  
Xiaohui Yin ◽  
Xiaoyue Zhai ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Integrin Β1 ◽  
Down Regulation ◽  
Renal Glomeruli

Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer

Pathobiology ◽  
2013 ◽  
Vol 80 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Kyung Han Nam ◽  
Byung Lan Lee ◽  
Joo Hyun Park ◽  
Jin Kim ◽  
Nayoung Han ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Poor Prognosis ◽  
Focal Adhesion Kinase Expression ◽  
Caveolin 1 ◽  
Kinase Expression

scholarly journals CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin β1/focal adhesion kinase pathway

2011 ◽  
Vol 58 (3,4) ◽  
pp. 188-196 ◽  
Author(s):  
Rentsenkhand Batmunkh ◽  
Yasuhiko Nishioka ◽  
Yoshinori Aono ◽  
Momoyo Azuma ◽  
Katsuhiro Kinoshita ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Lung Fibroblasts ◽  
Integrin Β1 ◽  
Kinase Pathway
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